Integration of biological systems through symbiosis: insights from aphid=Buchnera endosymbiosis
Project/Area Number |
25291083
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Evolutionary biology
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Research Institution | National Institute for Basic Biology |
Principal Investigator |
SHIGENOBU Shuji 基礎生物学研究所, 生物機能解析センター, 特任准教授 (30399555)
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Research Collaborator |
Stern David L. HHMI Janelia Research Campus
Aishwarya Korgaonkar HHMI Janelia Research Campus
Betzig Eric HHMI Janelia Research Campus
Li Wei-Ping HHMI Janelia Research Campus
Rivlin Pat HHMI Janelia Research Campus
Mergaert Peter CNRS
UCHIUMI Toshiki 鹿児島大学
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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Keywords | 共生 / アブラムシ / 進化 / 抗菌ペプチド |
Outline of Final Research Achievements |
A key question in symbiosis studies is how multiple organisms are integrated in a well-organized system through symbiosis. I used aphid-Buchnera symbiosis as a model to address this issue at molecular level. I focus on BCR peptides that are aphid lineage-specific secretion peptides I have discovered in the pea aphid genome. I found that these BCRs are expressed strongly and exclusively in the symbiotic organ called bacteriocytes. Our imaging data indicated that these peptides are secreted and then targeted to the endosymbionts. I also found BCRs have antimicrobial effects on E. coli and some other bacteria. Recently, antimicrobial peptide (AMP)-like peptides have been reported to function in the context of mutualism in other symbiotic systems such as Medicago-Rizobium symbiosis. AMP-like molecule such as BCRs should be a key to understand the principle in the symbiosis evolution.
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Report
(4 results)
Research Products
(17 results)
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[Presentation] 共生をゲノムから理解する2015
Author(s)
重信秀治
Organizer
第16回静岡ライフサイエンスシンポジウム
Place of Presentation
静岡大学(静岡県・静岡)
Year and Date
2015-03-07
Related Report
Invited
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