Genetic basis for invasiveness of alien species

• Project/Area Number: 25291096
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Ecology/Environment
• Research Institution: Tohoku University
• Principal Investigator: Makino Takashi 東北大学, 生命科学研究科, 准教授 (20443442)
• Co-Investigator(Renkei-kenkyūsha): Kawata Masakado 東北大学, 大学院生命科学研究科, 教授 (90204734)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 遺伝子重複 / 外来種 / 適応力 / 進化生態 / ゲノム / 環境適応

Outline of Final Research Achievements

Species vary their adaptability to novel environments. We investigated a relationship between the proportion of duplicated genes in animal genomes and their ecological features to predict adaptability of species based on genomic sequences. We sequenced a genome of invasive species Procambarus clarkii with high adaptability, and found that P. clarkii had the highest proportion of duplicated genes compared to other fully sequenced invertebrates.

Research Products

• [Journal Article] Contribution of non-ohnologous duplicated genes to high habitat variability in mammals (2014)
  • Author(s): Tamate C.S., Kawata M., Makino T.
  • Journal Title: Molecular Biology and Evolution Volume: 31 Issue: 7 Pages: 1779-1786
  • DOI: 10.1093/molbev/msu128
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 重複遺伝子が生み出す生命システムのロバストネス (2014)
  • Author(s): 牧野能士
  • Journal Title: 細胞工学 Volume: 33 Pages: 73-78
• [Journal Article] Ohnologs are overrepresented in pathogenic copy number mutations (2014)
  • Author(s): McLysaght, A., Makino, T., Grayton, H., Tropeano, M., Mitchell, K., Vassos, E. and Collier, DA.
  • Journal Title: PNAS Volume: 111 Issue: 1 Pages: 361-366
  • DOI: 10.1073/pnas.1309324111
  • Peer Reviewed
• [Journal Article] Contribution of non-ohnologous duplicated genes to high habitat variability in mammals (2014)
  • Author(s): Tamate, C.S., Kawata, M. and Makino, T.
  • Journal Title: Molecular Biology and Evolution Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Genome-wide deserts for copy number variation in vertebrates. (2013)
  • Author(s): Makino, T., McLysaght, A. and Kawata, M.
  • Journal Title: Nature Communications Volume: 4 Issue: 1 Pages: 2283-2283
  • DOI: 10.1038/ncomms3283
  • Peer Reviewed
• [Presentation] Genome-wide deserts for copy number variation in vertebrates (2014)
  • Author(s): Makino, T.
  • Organizer: Plant and Animal Genomics XXII
  • Place of Presentation: サンディエゴ, アメリカ
  • Invited
• [Presentation] Genome-wide deserts for copy number variation in vertebrates (2014)
  • Author(s): Makino, T.
  • Organizer: SMBE Satellite Meeting: The Causes of Genome Evolution
  • Place of Presentation: 静岡県三島市
  • Invited
• [Remarks] ホームページ
  • URL: http://meme.biology.tohoku.ac.jp/klabo-wiki/index.php?%CB%D2%CC%EE%C7%BD%BB%CE
• [Remarks] 牧野能士のページ
  • URL: http://meme.biology.tohoku.ac.jp/klabo-wiki/index.php?%CB%D2%CC%EE%C7%BD%BB%CE