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Polymorphisms associated with obesity/lipid metabolism/carbohydrate metabolism in Oceanic populations

Research Project

Project/Area Number 25291103
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Physical anthropology
Research InstitutionThe University of Tokyo (2014-2015)
University of Tsukuba (2013)

Principal Investigator

Ohashi Jun  東京大学, 理学(系)研究科(研究院), 准教授 (80301141)

Co-Investigator(Kenkyū-buntansha) Furusawa Takuro  京都大学, アジア・アフリカ地域研究研究科, 准教授 (50422457)
Nishida Nao  国立研究開発法人国立国際医療研究センター, 肝炎免疫研究センター, 上級研究員 (50456109)
Nakayama Kazuhiro  自治医科大学, 医学部, 講師 (90433581)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsオセアニア / 肥満 / 脂質代謝 / 多様性 / 進化 / 自然選択 / 多型 / 移住
Outline of Final Research Achievements

Analysis of the genome-wide SNP data suggested that the Polynesian ancestor came from Southeast Asia to Melanesia and mixed with indigenous Melanesian. The present-day Polynesian may have had obesity-risk alleles both from Southeast Asians and indigenous Melanesian.
Oleoylethanolamide (OEA), an appetite-suppressing mediator, is degraded by an integral membrane enzyme encoded by the fatty acid amide hydrolase (FAAH) gene. A previous study demonstrated that the activity of FAAH enzyme was influenced by a non-synonymous SNP (rs324420; Pro129Thr) in the FAAH gene. The FAAH activity was higher in peripheral blood T-lymphocytes obtained from subjects homozygous for rs324420-C (129Pro) than in those for rs324420-A (129Thr). In the present study, the rs324420-C allele was significantly associated with increase in BMI. Our results suggest that the efficient degradation of OEA caused by FAAH rs324420-C may lead to excessive food intake and significant weight gain in Oceanic populations.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013

All Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups.2016

    • Author(s)
      Boonvisut S, Nakayama K, Makishima S, Watanabe K, Miyashita H, Lkhagvasuren M,Kagawa Y, Iwamoto S
    • Journal Title

      Lipids Health Dis.

      Volume: 15 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s12944-016-0181-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals.2015

    • Author(s)
      N. Nishida, J. Ohashi, M. Sugiyama, T. Tsuchiura, K. Yamamoto, K. Hino, M. Honda, S. Kaneko, H. Yatsuhashi, K. Koike, O. Yokosuka, E. Tanaka, A. Taketomi, M. Kurosaki, N. Izumi, N. Sakamoto, Y. Eguchi, T. Sasazuki, K. Tokunaga, and M. Mizokami
    • Journal Title

      Tissue Antigens

      Volume: 5 Issue: 6 Pages: 406-412

    • DOI

      10.1111/tan.12684

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The role of TRIB1 in lipid metabolism; from genetics to pathways.2015

    • Author(s)
      Iwamoto S, Boonvisut S, Makishima S, Ishizuka Y, Watanabe K, Nakayama K
    • Journal Title

      Biochem Soc Trans.

      Volume: 43 Issue: 5 Pages: 1063-1068

    • DOI

      10.1042/bst20150094

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression.2015

    • Author(s)
      Makishima S, Boonvisut S, Ishizuka Y, Watanabe K, Nakayama K, Iwamoto S.
    • Journal Title

      J Lipid Res.

      Volume: 56 Issue: 6 Pages: 1145-1152

    • DOI

      10.1194/jlr.m057802

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic evidence for contribution of human dispersal to the genetic diversity of EBA-175 in Plasmodium falciparum2015

    • Author(s)
      Yoshiki Yasukochi, Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Jun Ohashi
    • Journal Title

      Malaria Journal

      Volume: 14 Issue: 1 Pages: 293-293

    • DOI

      10.1186/s12936-015-0820-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014

    • Author(s)
      Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, (省略), Tokunaga K, and Mizokami M
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e86449-e86449

    • DOI

      10.1371/journal.pone.0086449

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL28B polymorphisms and clinical implications for hepatitis C virus infection in Uzbekistan2014

    • Author(s)
      Khudayberganova D, Sugiyama M, Masaki N, Nishida N, Mukaide M, Sekler D, Latipov R, Nataliya K, Dildora S, Sharapov S, Usmanova G, Raxmanov M, Musabaev E, Mizokami M
    • Journal Title

      PLoS One

      Volume: 24;9 Issue: 3 Pages: e93011-e93011

    • DOI

      10.1371/journal.pone.0093011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.2014

    • Author(s)
      Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, Iwasaki Y, Yada T, Yanagisawa Y, Miyashita H, Takahashi M, Iwamoto S; Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan
    • Journal Title

      J Mol Endocrinol

      Volume: 52 Issue: 2 Pages: 145-158

    • DOI

      10.1530/jme-13-0243

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of ADRB2 polymorphism with triglyceride levels in Tongans.2013

    • Author(s)
      Naka I, Ohashi J, Kimura R, Inaoka T, Matsumura Y
    • Journal Title

      Lipids in Health and Disease

      Volume: 12 Issue: 1 Pages: 110-110

    • DOI

      10.1186/1476-511x-12-110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia2013

    • Author(s)
      Furusawa T
    • Journal Title

      Journal of Human Genetics

      Volume: (in press) Issue: 3 Pages: 142-149

    • DOI

      10.1038/jhg.2012.147

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal effects of UCP1 gene polymorphism on visceral fat accumulation in Japanese adults2013

    • Author(s)
      Nakayama K, Miyashita H, Yanagisawa Y, Iwamoto S
    • Journal Title

      PLOS One

      Volume: 8 Issue: 9 Pages: e74720-e74720

    • DOI

      10.1371/journal.pone.0074720

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] オセアニア集団におけるFAAH遺伝子Pro129Thr多型とBMIとの関連2014

    • Author(s)
      中 伊津美 ほか
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      東京・船堀
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Significant association of Pro129Thr polymorphism in the fatty acid amide hydrolase (FAAH) gene with body mas index in Oceanic populations2014

    • Author(s)
      Naka et al.
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Significant association of perilipin polymorphisms with LDL-cholesterol level2013

    • Author(s)
      Izumi Naka, Ryosuke Kimura, Tsukasa Inaoka, Yasuhiro Matsumura, Jun Ohashi
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] トンガ人集団におけるPLIN1遺伝子多型とLDLコレステロールとの関連2013

    • Author(s)
      中伊津美、木村亮介、稲岡司、松村康弘、大橋順
    • Organizer
      日本人類学会
    • Place of Presentation
      茨城県つくば市
    • Related Report
      2013 Annual Research Report
  • [Presentation] トンガ人集団におけるPLIN1遺伝子多型とLDLコレステロールとの関連2013

    • Author(s)
      中伊津美、木村亮介、稲岡司、松村康弘、大橋順
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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