Human migration and evolution inferred from parasitic organisms

• Project/Area Number: 25291105
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Physical anthropology
• Research Institution: The University of Tokyo
• Principal Investigator: Ishida Takafumi 東京大学, 理学(系)研究科(研究院), 教授 (20184533)
• Research Collaborator: MURANO Yukari ; MOROTOMI Nozomi
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 寄生体 / ウイルス / 移動 / 系統 / 進化 / ヒト / 小進化 / 適応遺伝 / 原虫 / 人類史 / 適応 / ゲノム / アジア

Outline of Final Research Achievements

To shed light on the maternal contribution to the EBV transmission to the offspring, EBV genomic information was collected from mother-offspring pairs; only one third of the pairs shared the identical nucleotide sequence, whereas no significant EBV genomic diversity was confirmed in between patrilocal communities and matrilocal communities. These results indicates that EBV is an inappropriate ethnic marker.
The 27-base deletion in the band 3 gene was suggested to be generated around 4000 years before in the central part of the Philippines by the haplotype analyses.

Research Products

• [Journal Article] Distributions of the GSTM1 and GSTT1 null genotypes worldwide are characterized by latitudinal clines. (2015)
  • Author(s): Marie Saitou and Takafumi Ishida
  • Journal Title: The Asian Pacific Journal of Cancer Prevention Volume: 16 Issue: 1 Pages: 355-61
  • DOI: 10.7314/apjcp.2015.16.1.355
  • Peer Reviewed / Open Access
• [Journal Article] A functional promoter polymorphism of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. (2013)
  • Author(s): Naka, I., Hikami, K., Nakayama, K., Koga, M., NIshida, N., Kimura, R., Furusawa, T., Natsuhara, K., Yamauchi, T., Nakazawa, M., Ataka, Y., Ishida, T., Inaoka, T., Munkhtulga, L., Iwamoto, S., Matsumura, Y., Ohtsuka, R. Tsuchiya, N. and Ohashi, J.
  • Journal Title: International Journal of Obesity Volume: 37 Pages: 1204-1210
  • Peer Reviewed
• [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia. (2013)
  • Author(s): Furusawa, T., Naka, I., Yamauchi, T., Natsuhara, K., Eddie, R., Kimura, R., Nakazawa, M., Ishida, T., Inaoka, T., Matsumura, Y., Ataka, Y., Ohtsuka, R. and Ohashi, J.
  • Journal Title: Journal of Human Genetics Volume: 58 Pages: 142-149
  • NAID: 10031164071
  • Peer Reviewed
• [Presentation] Non-invasive detection of simian γ-lymphocryptovirus in free-ranging Japanese macaques (2016)
  • Author(s): Nozomi Morotomi, Yukari Murano and Takafumi Ishida
  • Organizer: Asian Society of Conservation Medicine
  • Place of Presentation: Taipei
  • Year and Date: 2016-10-23
  • Int'l Joint Research