Screening of novel plant defense activators targeting salicylic acid glucosyltransferase
| Project/Area Number |
25292035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plant protection science
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 植物 / 酵素 / 生理活性 / 環境調和型農林水産 / プラントアクチベーター |
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| Outline of Final Research Achievements |
Plant defense activator confers disease resistance in plants by activating immune response. A phytohormone salicylic acid (SA) controls defense response and it is inactivated by glucosylation by an enzyme glucosyltransferase (SAGT). Since inhibition of SAGT enhanced plant immune response, we look for novel SAGT inhibitors as a lead compound for practical agrochemical. From the screening of over 200,000 diverse organic molecules supplied by Drug Discovery Initiative of University of Tokyo, we successfully identified 12 compounds which strongly inhibited Arabidopsis SAGT. They actually upregulated immune response of Arabidopsis suspension culture. Their activities on plants and inhibition constants are being analyzed. Their potentials as agrochemical will be evaluated in the crop field in collaboration with companies.
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] The plant cell wall as a site for molecular contacts in fungal pathogenesis2016
Author(s)
Kazuhiro Toyoda, Sachiyo Yao, Mai Takagi, Maki Uchioki, Momiji Miki, Kaori Tanaka, Tomoko Suzuki, Masashi Amano, Akinori Kiba, Toshiaki Kato, Hirotaka Takahashi, Yasuhiro Ishiga, Hidenori Matsui, Yoshiteru Noutoshi, Mikihiro Yamamoto, Yuki Ichinose and Tomonori Shiraishi
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Journal Title
Physiological and Molecular Plant Pathology
Volume: 95
Pages: 44-49
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Expression profiling of marker genes responsive to the defence-associated phytohormones salicylic acid, jasmonic acid and ethylene in Brachypodium distachyon.2016
Author(s)
Kouzai, Y., Kimura, M., Yamanaka, Y., Watanabe, M., Matsui, H., Yamamoto, M., Ichinose, Y., Toyoda, K., Onda, Y., Mochida, K. and Noutoshi, Y.
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Journal Title
BMC Plant Biology
Volume: 16
Issue: 1
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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