| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In Streptomyces coelicolor growing in soil amended with chitin, a transcription factor DasR is involved in the regulation of expression of chitin metabolism-related genes and antibiotic production genes. In this study, in order to clarify the metabolic regulation cascade around the DasR, we tried to find factors which regulate dasR expression. As a result, we found that DasR itself binds strongly to dasR promoter, also that a transcription factor whose deletion leads to over production of chitinase and loss of catabolite repression of chitinase production controls expression of dasR.
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