| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Bacterial polyhydroxyalkanoates has been attracted much attention as bio-based eco-friendly polymeric materials. This study focused on biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanote) from inexpensive biomass resources by engineered strains of Ralstonia eutropha. The biosynthesis from vegetable oils was improved by modification of beta-oxidation pathway, and an artificial pathway was established for the biosynthesis from structurally unrelated sugars. Metabolomic analysis was performed to obtain knowledge for the global metabolisms. Finally, the range of utilizable carbon sources by this bacterium was expanded by metabolic engineering. These results are expected to be useful for establishment of low-cost microbial production of PHAs with superior properties.
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