| Project/Area Number |
25292061
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KATAOKA Takao 京都工芸繊維大学, その他部局等, 教授 (20242307)
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| Co-Investigator(Renkei-kenkyūsha) |
USUI Takeo 筑波大学, 生命環境系, 准教授 (60281648)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 炎症性サイトカイン / バイオプローブ / 情報伝達 / NF-κB / イルシニアスタチンA / アラントピロンA / トリテルペノイド / カルデノリドアグリコン / ICAM-1 / ベツリン酸 / オレアノール酸 / ウルソール酸 / α-グルコシダーゼ / VCAM-1 / 糖鎖修飾 / 強心配糖体 / アグリコン / ウアバジェニン / ジギトキシジェニン / ジゴキシジェニン / Na+/K+-ATPase / TNFレセプター1 / ERK / タンパク質輸送 / カスパーゼ8 / c-FLIP |
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| Outline of Final Research Achievements |
Cytokine receptors regulating inflammatory responses activate the transcription factor nuclear factor κB (NF-κB) signaling pathway by various adaptor proteins and protein kinases. The NF-κB pathway induces the transcription of many genes, such as those encoding cytokines, chemokines, and adhesion molecules, and regulates inflammatory responses by their gene expression. In this study, the molecular mechanisms of the signaling pathways and gene expression induced by inflammatory cytokines were elucidated largely by using small molecules as bioprobes.
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