Functional analysis of cells expressing taste-related genes in the gastrointestinal tract
| Project/Area Number |
25292068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHIMARU YOSHIRO 東京大学, 農学生命科学研究科, 特任准教授 (10451840)
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| Co-Investigator(Renkei-kenkyūsha) |
MISAKA Takumi 東京大学, 大学院農学生命科学研究科, 准教授 (40373196)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | 受容体 / 消化管 / 代謝 / 栄養素 / 遺伝子破壊マウス |
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| Outline of Final Research Achievements |
The mechanisms of differentiation and the function of tuft cells, which constitute about 0.4% of the intestinal epithelium, remain elusive. Here we show that both tuft cells and type II taste cells are eliminated in the gastrointestinal (GI) tract of transcription factor Skn-1 knockout (KO) mice. Despite unaltered food intake, Skn-1 KO mice have reduced body weight with lower body fat due to increased energy expenditure. In this model, 24-hr urinary excretion of catecholamines was significantly elevated, accompanied by increased fatty acid beta-oxidation and fuel dissipation in skeletal muscle and impaired insulin secretion driven by glucose. These results suggest the existence of brain-mediated energy homeostatic pathways originating from tuft cells and type II taste cells in the GI tract and ending in peripheral tissues, including the adrenal glands. The discovery of food-derived factors that regulate these cells may open new avenues for the treatment of obesity and diabetes.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Expression of serotonin receptor genes in cranial ganglia.2016
Author(s)
Maeda, N., Ohmoto, M., Yamamoto, K., Kurokawa, A., Narukawa, M., Ishimaru, Y., Misaka, T., Matsumoto, I., Abe, K.
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Journal Title
Neurosci Lett
Volume: 617
Pages: 46-51
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Long-Chain Fatty Acids Elicit a Bitterness-Masking Effect on Quinine and Other Nitrogenous Bitter Substances by Formation of Insoluble Binary Complexes.2015
Author(s)
Ogi, K., Yamashita, H., Terada, T., Homma, R., Shimizu-Ibuka, A., Yoshimura, E., Ishimaru, Y., Abe, K., and Asakura, T.
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Journal Title
J. Agric. Food Chem.
Volume: 63
Issue: 38
Pages: 8493-8500
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rapid Expansion of Phenylthiocarbamide Non-Tasters among Japanese Macaques.2015
Author(s)
Suzuki-Hashido, N., Hayakawa, T., Matsui, A., Go, Y., Ishimaru, Y., Misaka, T., Abe, K., Hirai, H., Satta, Y., and Imai, H.
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Journal Title
PLoS ONE
Volume: 22
Issue: 7
Pages: e0132016-e0132016
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Additional nitrogen fertilization at heading time of rice down-regulates cellulose synthesis in seed endosperm.2014
Author(s)
Midorikawa, K., Kuroda, M., Terauchi, K., Hoshi, M., Ikenaga, S., Ishimaru, Y., Abe, K., Asakura, T.
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Journal Title
PLoS One
Volume: 9
Issue: 6
Pages: e98738-e98738
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Loss of brush cells and taste cells in the gastrointestinal tract alters energy metabolism in Skn-1-deficient mice.2015
Author(s)
Ishimaru, Y., Ushiama, S., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Osakabe, N., Asakura, T., Masuzaki, H., Abe, K.
Organizer
ECRO 2015
Place of Presentation
Istanbul, Turky
Year and Date
2015-09-02
Related Report
Int'l Joint Research
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