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Study for design of artificial fats based on analysis of cephalic signal of fats

Research Project

Project/Area Number 25292071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Food science
Research InstitutionRyukoku University (2015)
Kyoto University

Principal Investigator

Fushiki Tohru  龍谷大学, 農学部, 教授 (20135544)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords嗜好性 / 油脂 / 脂肪酸 / 頭相 / 油脂酸化生成物 / 嗅覚 / fatty acid / palatability / cephalic / dietary fat / cooking / 頭相信号
Outline of Final Research Achievements

The palatability of fat is an important topic for research on food products, as it is challenging to think of how to develop food products without fat that nevertheless appeal to the taste preferences of contemporary consumers. However, the excessive intake of fat has contributed to increases in obesity and lifestyle-related diseases. In the present study, I showed that a relatively small amount of fatty acids can substitute for the stimulus of fat on the tongue as an antagonist for putative fat receptor. Moreover,the flavor of fatty acids and volatile compounds derived from fats signal the chemical presence of fats that contributes to the sensation of deliciousness, stimulating the recall of memories of eating fatty foods.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 6 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] <b>A role of CD36 in the perception of an oxidised phospholipid species in </b><b>mice </b>2015

    • Author(s)
      Lee S, Eguchi A,Sakamoto K, Matsumura S, Tsuzuki S, Inoue K, Masuda D, Yamashita S, Fushiki
    • Journal Title

      Biomedical Research

      Volume: 36 Issue: 5 Pages: 303-311

    • DOI

      10.2220/biomedres.36.303

    • NAID

      130005106625

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression of CD36 by olfactory receptor cells and its abundance on the epithelial surface in mice2015

    • Author(s)
      Lee S, Eguchi A,Sakamoto K, Matsumura S, Tsuzuki S, Inoue K, Iwanaga T, Masuda D, Yamashita S, Fushiki
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0133412-e0133412

    • DOI

      10.1371/journal.pone.0133412

    • NAID

      120005756270

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanisms Involved in Guiding the Preference for Fat Emulsion Differ Depending on the Concentration2015

    • Author(s)
      Sakamoito K, Matsumura S, Okafuji Y, Eguchi A, Lee S, Adachi S, Fujitani M, Tsuzuki S, Inoue K, Fushiiki T
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 61 Issue: 3 Pages: 247-254

    • DOI

      10.3177/jnsv.61.247

    • NAID

      130005089920

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The opioid system contributes to the acquisition of reinforcement for dietary fat but is not required for its maintenance.2015

    • Author(s)
      Sakamoto K, Matsumura S, Okafuji Y, Eguchi A, Yoneda T, Mizushige T, Tsuzuki S, Inoue K, Fushiki T.
    • Journal Title

      Physiol Behav.

      Volume: 138 Pages: 227-35

    • DOI

      10.1016/j.physbeh.2014.11.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The opioid system majorly contributes to preference for fat emulsions but not sucrose solutions in mice2014

    • Author(s)
      Sakamoto K, Okahashi T, Matsumura S, Okafuji Y, Adachi S, Tsuzuki S, Inoue K, Fushiki T
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 79 Issue: 4 Pages: 658-663

    • DOI

      10.1080/09168451.2014.991688

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Why fat is so preferable: from oral fat detection to inducing reward in the brain2014

    • Author(s)
      Fushiki T
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 78 Issue: 3 Pages: 363-369

    • DOI

      10.1080/09168451.2014.905186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of Aroma Components from Oxidized Olive Oil on Preference2013

    • Author(s)
      Nakano K, Kubo H, Matsumura S, Saito T, Fushiki T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 6 Pages: 1166-1170

    • DOI

      10.1271/bbb.120861

    • NAID

      10031184676

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脂肪関連物質のモデルCD36ペプチドへの結合能の評価2014

    • Author(s)
      香西裕貴
    • Organizer
      第53回日本栄養・食糧学会 近畿支部大会
    • Place of Presentation
      京都府立大学
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 種々の低濃度脂肪酸溶液摂取時の側坐核ドーパミン遊離量の変化2014

    • Author(s)
      安達真一
    • Organizer
      日本味と匂学会 第48回大会
    • Place of Presentation
      静岡市清水文化会館マリナート
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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