Studies on the modulation of biological functions by food factors through the action of aryl hydrocarbon receptor
| Project/Area Number |
25292072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kobe University |
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Principal Investigator |
Ashida Hitoshi 神戸大学, (連合)農学研究科(研究院), 教授 (90201889)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | アリール炭化水素受容体 / ダイオキシン / ポリフェノール / ケンフェロール / クルクミン / ルテオリン / 薬物代謝 / 脂肪細胞分化 / 分子栄養学 |
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| Outline of Final Research Achievements |
In this study, we investigated the functions of polyphenols on an aryl hydrocarbon receptor (AhR)-dependent actions. We obtained following findings: (1) Luteolin, kaempferol, curcumin, and procyanidin suppressed TCDD (an AhR agonist)-induced expression of drug-metabolizing enzymes through inhibition of AhR transformation; (2) Luteolin canceled TCDD-inhibited adipocyte differentiation through suppression of AhR nuclear translocation; (3) Luteolin, kaempferol, and curcumin rapidly incorporated into hepatocytes and adipocytes as mainly an aglyconefom, and thereafter they modulated AhR-dependent actions; and (4) Chalcones such as cardamonin suppressed AhR transformation. These results indicate that certain polyphenols possess multi-functional suppressive effect against AhR-dependent actions for the toxicities of TCDD.
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Report
(4 results)
Research Products
(29 results)
