| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
In this study, we investigated the functions of polyphenols on an aryl hydrocarbon receptor (AhR)-dependent actions. We obtained following findings: (1) Luteolin, kaempferol, curcumin, and procyanidin suppressed TCDD (an AhR agonist)-induced expression of drug-metabolizing enzymes through inhibition of AhR transformation; (2) Luteolin canceled TCDD-inhibited adipocyte differentiation through suppression of AhR nuclear translocation; (3) Luteolin, kaempferol, and curcumin rapidly incorporated into hepatocytes and adipocytes as mainly an aglyconefom, and thereafter they modulated AhR-dependent actions; and (4) Chalcones such as cardamonin suppressed AhR transformation. These results indicate that certain polyphenols possess multi-functional suppressive effect against AhR-dependent actions for the toxicities of TCDD.
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