| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
A well-balanced body energy budget is controlled by limiting calorie intake and/or increasing energy expenditure, which is typically achieved by appropriate physical exercise, and is the most effective treatment for obesity and diabetes mellitus. In this study, we showed that PGC1α and FOXO1 are critical regulators of amino acid metabolism in skeletal muscle (BCAA and glutamine, respectively). Our aims are to better understand the molecular mechanisms underlying skeletal muscle metabolism, establish novel strategies for the prevention of lifestyle-related diseases and sarcopenia, and establish a fundamental biological basis for the effects of functional foods.
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