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Role of PGC1alpha and FOXO1 in skeletal muscle amino acid metabolism, and muscle mass

Research Project

Project/Area Number 25292076
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Food science
Research InstitutionKyoto Prefectural University

Principal Investigator

Kamei Yasutomi  京都府立大学, 生命環境科学研究科(系), 教授 (70300829)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords骨格筋 / 転写調節 / 運動 / 代謝 / アミノ酸代謝 / BCAA / アミノ酸 / 遺伝子発現
Outline of Final Research Achievements

A well-balanced body energy budget is controlled by limiting calorie intake and/or increasing energy expenditure, which is typically achieved by appropriate physical exercise, and is the most effective treatment for obesity and diabetes mellitus. In this study, we showed that PGC1α and FOXO1 are critical regulators of amino acid metabolism in skeletal muscle (BCAA and glutamine, respectively). Our aims are to better understand the molecular mechanisms underlying skeletal muscle metabolism, establish novel strategies for the prevention of lifestyle-related diseases and sarcopenia, and establish a fundamental biological basis for the effects of functional foods.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report

Research Products

(41 results)

All 2016 2015 2014 2013 Other

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Acknowledgement Compliant: 9 results,  Open Access: 9 results) Presentation (20 results) (of which Int'l Joint Research: 2 results,  Invited: 11 results) Book (5 results) Remarks (2 results)

  • [Journal Article] FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation.2016

    • Author(s)
      Yamashita A, Hatazawa Y, Hirose Y, Ono Y, Kamei Y
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity.2016

    • Author(s)
      Morita S, Nakabayashi K, Kawai T, Hayashi K, Horii T, Kimura M, Kamei Y, Ogawa Y, Hata K, Hatada I
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 21693-21693

    • DOI

      10.1038/srep21693

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice.2016

    • Author(s)
      Yoshimura R, Minami K, Matsuda J, Sawada N, Miura S, Kamei Y.
    • Journal Title

      Biosci Biotech Biochem

      Volume: 80(2) Pages: 288-290

    • DOI

      10.1080/09168451.2015.1083397

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Down Regulation of Asparagine Synthetase and 3-Phosphoglycerate Dehydrogenase, and the Up-Regulation of Serine Dehydratase in Rat Liver from Intake of Excess Amount of Leucine Are Not Related to Leucine-Caused Amino Acid Imbalance2015

    • Author(s)
      Yoshimura, R., Takai, M., Namaki, H., Minami, K., Imamura, W., Kato, H., Kamei, Y., and Kanamoto, R.
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 61 Issue: 6 Pages: 441-448

    • DOI

      10.3177/jnsv.61.441

    • NAID

      130005125480

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.2015

    • Author(s)
      Senoo N, Miyoshi N, Goto-Inoue N, Minami K, Yoshimura R, Morita A, Sawada N, Matsuda J, Ogawa Y, Setou M, Kamei Y, Miura S.
    • Journal Title

      J Lipid Res

      Volume: 56 Pages: 2286-2296

    • DOI

      10.1194/jlr.m060533

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α.2015

    • Author(s)
      Hatazawa Y, Senoo N, Tadaishi M, Ogawa Y, Ezaki O, Kamei Y, Miura S.
    • Journal Title

      PLoS ONE

      Volume: 10

    • DOI

      10.1371/journal.pone.0129084

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ATM regulates adipocyte differentiation and contributes to glucose homeostasis.2015

    • Author(s)
      Takagi M., Uno M., Nishii R., Sugimoto M., Hasegawa S., Piao J., Ihara N., Kanai S., Kakei S., Tamura Y., Suganami T., Kamei Y., Shimizu T., Yasuda A., Ogawa Y., Mizutani S.
    • Journal Title

      Cell Rep.

      Volume: 10 Pages: 00052-2

    • DOI

      10.1016/j.celrep.2015.01.027

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.2015

    • Author(s)
      Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimoto K, Tamiya T, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y.
    • Journal Title

      Diabetes

      Volume: 64(3) Pages: 775-784

    • DOI

      10.2337/db14-0158

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR: possible contribution to ammonia detoxification.2014

    • Author(s)
      Kamei Y, Hattori M, Hatazawa Y, Kasahara T, Kanou M, Kanai S, Yuan X, Suganami T, Lamers WH, Kitamura T, Ogawa Y.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 307

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle.2014

    • Author(s)
      Y. Hatazawa, M. Tadaishi, Y. Nagaike, A. Morita, Y. Ogawa, O. Ezaki, T. Takai-Igarashi, Y. Kitaura, Y. Shimomura, Y. Kamei*, S. Miura*
    • Journal Title

      PLoS ONE

      Volume: 9

    • DOI

      10.1371/journal.pone.0091006

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Endothelial PGC-1α mediates vascular dysfunction in diabetes2014

    • Author(s)
      N. Sawada, A. Jiang, F. Takizawa, A. Safdar, A. Manika, Y. Tesmenitsky, K.-T. Kang, J. Bischoff, H. Kalwa, J.L. Sartoretto, Y. Kamei, L.E. Benjamin, H. Watada, Y. Ogawa, Y. Higashikuni, C.W. Kessinger, F.A. Jaffer, T. Michel, M. Sata, K. Croce, R. Tanaka, Z Arany
    • Journal Title

      Cell Metab.

      Volume: 19 Pages: 246-258

    • DOI

      10.1016/j.cmet.2013.12.014

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Downregulation of Pgc-1α expression by tea leaves and their by-products2014

    • Author(s)
      Shibuya E, Murakami M, Kondo M, Kamei Y, Tomonaga S, Matsui T, Funaba M
    • Journal Title

      Cell Biochem Funct.

      Volume: 32 Pages: 236-240

    • DOI

      10.1002/cbf.3006

    • NAID

      120005623240

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of exercise- and training-induced fatty acid oxidation in skeletal muscle.2014

    • Author(s)
      S. Miura, M. Tadaishi, Y. Kamei, O. Ezaki.
    • Journal Title

      J. Physical Fitness and Sports Medicine

      Volume: 印刷中

    • NAID

      130003397904

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FoxO1 Inhibits Skeletal Muscle Hypertrophy Through mTOR-independent Mechanisms.2013

    • Author(s)
      R. A. Potter, A. D. DeLong, S. M. Smith, B. M. Erb, B. Renwand, Y. Kamei, Y. Ogawa, T. J. McLoughlin.
    • Journal Title

      Journal of Exercise Physiology

      Volume: 16 Pages: 32-50

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨格筋の代謝におけるアミノ酸の機能と分子機序2015

    • Author(s)
      亀井康富
    • Organizer
      国際アミノ酸学会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 運動や栄養環境変化による遺伝子発現変化と生活習慣病予防2015

    • Author(s)
      亀井康富
    • Organizer
      第6回岐阜薬科大学機能性健康食品(蜂産品)研究講演会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 骨格筋PGC1α欠損マウスへのBCAA摂取による脳内キヌレン酸量の減少2015

    • Author(s)
      亀井康富、関根愛莉、吉村亮二、南貴美子、福渡努
    • Organizer
      アミノ酸学会
    • Place of Presentation
      滋賀
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生活習慣病に関する遺伝子発現制御2015

    • Author(s)
      亀井康富
    • Organizer
      第4回 奥伊勢Forum
    • Place of Presentation
      三重
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Skeletal muscle metabolism during exercise and its interaction with obesity2015

    • Author(s)
      亀井康富
    • Organizer
      Kyoto Conference of Young Lions in Obesity Research
    • Place of Presentation
      京都
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マウス骨格筋において転写共役因子PGC1αはBCAA代謝を促進する2015

    • Author(s)
      亀井康富、畑澤幸乃、只石幹、小川佳宏、北浦靖之、下村吉治、三浦進司
    • Organizer
      日本肥満学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨格筋のエネルギー代謝制御因子PGC1α2015

    • Author(s)
      亀井康富、三浦進司
    • Organizer
      日本農芸化学会中部・関西支部合同大会
    • Place of Presentation
      富山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] PGC1α-Tgマウスの骨格筋におけるメタボローム解析2015

    • Author(s)
      亀井康富、畑澤幸乃、妹尾奈波、小川佳宏、三浦進司
    • Organizer
      日本肥満学会adiposcienceシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨格筋代謝と肥満―マウスモデルを用いた検討―2015

    • Author(s)
      亀井康富
    • Organizer
      第23回日本運動生理学会大会シンポジウム
    • Place of Presentation
      東京都品川区
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism of gene expression in skeletal muscle function and amino acid metabolism2015

    • Author(s)
      Yasutomi Kamei, Shinji Miura, Yoshihiro Ogawa
    • Organizer
      12TH Asian Congress of Nutrition
    • Place of Presentation
      横浜
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 核内受容体・転写共役因子と骨格筋代謝2014

    • Author(s)
      亀井康富
    • Organizer
      第一回バイオ・フロンティア・プラットフォームシンポジウム
    • Place of Presentation
      京都府京都市
    • Year and Date
      2014-12-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] FOXO1は骨格筋のグルタミン代謝を活性化する2014

    • Author(s)
      亀井康富、服部真季、畑澤幸乃、金井紗綾香、北村忠弘、小川佳宏
    • Organizer
      日本アミノ酸学会 第8回学術大会
    • Place of Presentation
      東京都世田谷区
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨格筋代謝の遺伝子発現制御2014

    • Author(s)
      亀井康富、三浦進司
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] FOXO1 activates glutamine synthetase gene in mouse skeletal muscles2014

    • Author(s)
      Yasutomi Kamei, Maki Hattori, Yukino Hatazawa, Tomomi Kasahara, Tadahiro Kitamura, Yoshihiro Ogawa
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      米国カリフォルニア州
    • Year and Date
      2014-04-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨格筋アミノ酸代謝における遺伝子発現制御2014

    • Author(s)
      亀井 康富
    • Organizer
      2014年度日本農芸化学会大会(シンポジウム)
    • Place of Presentation
      神奈川県川崎市
    • Year and Date
      2014-04-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 核内受容体コファクターによる骨格筋アミノ酸代謝制御2014

    • Author(s)
      畑澤幸乃、只石幹、長池祐太、守田昭仁、小川佳宏、江崎治、北浦靖之、下村吉治、亀井康富、三浦進司
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遺伝子改変動物を用いた筋サテライト細胞の分化能解析2014

    • Author(s)
      山下敦史、畑澤幸乃、吉村亮二、小川祥加、小野悠介、亀井康富
    • Organizer
      日本農芸化学会関西支部第 483 回 講演会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ロイシン摂取によるmTORC1経路活性化に及ぼすPGC-1αの影響2013

    • Author(s)
      吉村亮二、佐藤沙耶、南貴美子、只石幹、三浦進司、亀井康富
    • Organizer
      日本農芸化学会関西支部第 482 回 講演会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス骨格筋における転写共役因子PGC-1αによるBCAA代謝調節2013

    • Author(s)
      畑澤幸乃、只石幹、長池祐太、守田昭仁、小川佳宏、江崎治、北浦靖之、下村吉治、亀井康富、三浦進司
    • Organizer
      第52回 日本栄養・食糧学会 近畿支部大会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨格筋機能と遺伝子発現制御2013

    • Author(s)
      亀井康富
    • Organizer
      日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 月刊糖尿病  骨格筋からみた糖尿病の病態と治療2015

    • Author(s)
      亀井康富,小川佳宏
    • Publisher
      医学出版
    • Related Report
      2015 Annual Research Report
  • [Book] 化学と生物 骨格筋と脂肪組織にかかわる最近の話題2015

    • Author(s)
      山下敦史、亀井康富
    • Publisher
      日本農芸化学会
    • Related Report
      2015 Annual Research Report
  • [Book] 骨格筋とオートファジー2015

    • Author(s)
      吉村亮二、亀井康富
    • Publisher
      内分泌・糖尿病・代謝内科
    • Related Report
      2015 Annual Research Report
  • [Book] 化学と生物「骨格筋と脂肪組織にかかわる最近の話題」2015

    • Author(s)
      山下敦史、亀井康富
    • Total Pages
      1
    • Publisher
      日本農芸化学会 会誌
    • Related Report
      2014 Annual Research Report
  • [Book] 月刊糖尿病 「骨格筋からみた糖尿病の病態と治療」2014

    • Author(s)
      亀井康富,小川佳宏
    • Total Pages
      6
    • Publisher
      医学出版
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都府立大学生命環境科学研究科分子栄養学研究室

    • URL

      http://nutrition.life.kpu.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 京都府立大学生命環境科学研究科分子栄養学研究室

    • URL

      http://nutrition.life.kpu.ac.jp/

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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