Role of PGC1alpha and FOXO1 in skeletal muscle amino acid metabolism, and muscle mass
| Project/Area Number |
25292076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
Kamei Yasutomi 京都府立大学, 生命環境科学研究科(系), 教授 (70300829)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 骨格筋 / 転写調節 / 運動 / 代謝 / アミノ酸代謝 / BCAA / アミノ酸 / 遺伝子発現 |
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| Outline of Final Research Achievements |
A well-balanced body energy budget is controlled by limiting calorie intake and/or increasing energy expenditure, which is typically achieved by appropriate physical exercise, and is the most effective treatment for obesity and diabetes mellitus. In this study, we showed that PGC1α and FOXO1 are critical regulators of amino acid metabolism in skeletal muscle (BCAA and glutamine, respectively). Our aims are to better understand the molecular mechanisms underlying skeletal muscle metabolism, establish novel strategies for the prevention of lifestyle-related diseases and sarcopenia, and establish a fundamental biological basis for the effects of functional foods.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Down Regulation of Asparagine Synthetase and 3-Phosphoglycerate Dehydrogenase, and the Up-Regulation of Serine Dehydratase in Rat Liver from Intake of Excess Amount of Leucine Are Not Related to Leucine-Caused Amino Acid Imbalance2015
Author(s)
Yoshimura, R., Takai, M., Namaki, H., Minami, K., Imamura, W., Kato, H., Kamei, Y., and Kanamoto, R.
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Journal Title
J Nutr Sci Vitaminol
Volume: 61
Issue: 6
Pages: 441-448
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.2015
Author(s)
Senoo N, Miyoshi N, Goto-Inoue N, Minami K, Yoshimura R, Morita A, Sawada N, Matsuda J, Ogawa Y, Setou M, Kamei Y, Miura S.
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Journal Title
J Lipid Res
Volume: 56
Pages: 2286-2296
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] ATM regulates adipocyte differentiation and contributes to glucose homeostasis.2015
Author(s)
Takagi M., Uno M., Nishii R., Sugimoto M., Hasegawa S., Piao J., Ihara N., Kanai S., Kakei S., Tamura Y., Suganami T., Kamei Y., Shimizu T., Yasuda A., Ogawa Y., Mizutani S.
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Journal Title
Cell Rep.
Volume: 10
Pages: 00052-2
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.2015
Author(s)
Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimoto K, Tamiya T, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y.
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Journal Title
Diabetes
Volume: 64(3)
Pages: 775-784
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR: possible contribution to ammonia detoxification.2014
Author(s)
Kamei Y, Hattori M, Hatazawa Y, Kasahara T, Kanou M, Kanai S, Yuan X, Suganami T, Lamers WH, Kitamura T, Ogawa Y.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 307
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle.2014
Author(s)
Y. Hatazawa, M. Tadaishi, Y. Nagaike, A. Morita, Y. Ogawa, O. Ezaki, T. Takai-Igarashi, Y. Kitaura, Y. Shimomura, Y. Kamei*, S. Miura*
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Endothelial PGC-1α mediates vascular dysfunction in diabetes2014
Author(s)
N. Sawada, A. Jiang, F. Takizawa, A. Safdar, A. Manika, Y. Tesmenitsky, K.-T. Kang, J. Bischoff, H. Kalwa, J.L. Sartoretto, Y. Kamei, L.E. Benjamin, H. Watada, Y. Ogawa, Y. Higashikuni, C.W. Kessinger, F.A. Jaffer, T. Michel, M. Sata, K. Croce, R. Tanaka, Z Arany
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Journal Title
Cell Metab.
Volume: 19
Pages: 246-258
DOI
Related Report
Peer Reviewed / Open Access
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