Elucidation of the anti-thrombotic property of food component and its application for the development of functional food.
| Project/Area Number |
25292077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
SEKI Taiichiro 日本大学, 生物資源科学部, 教授 (20187834)
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| Co-Investigator(Kenkyū-buntansha) |
HOSONO Takashi 日本大学, 生物資源科学部, 講師 (80445741)
SHEN Yan 日本大学, 生物資源科学部, 研究員 (80614007)
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| Research Collaborator |
YAGUCHI Manami
OKUE Sachiko
OKAMOTO Atsushi
SATO Asuka
MIURA Atsushi
NISHIMURA Satoshi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 食品機能 / 生活習慣病 / 血液凝固 / garlic / thrombosis |
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| Outline of Final Research Achievements |
Thrombotic diseases including myocardial infarction and cerebrovascular diseases are the major causes of death. Blood coagulation factor III (tissue factor) is highly expressed on the arteriosclerotic region and triggering thrombotic diseases. In this study, we characterized the tissue factor as molecular target of food factors as well as elucidating novel regulatory mechanism(s) of hemostasis to develop the food function. We demonstrated the anti-thrombotic property of garlic derived component diallyl trisulfide (DATS) at molecular basis. DATS inhibits thrombus formation through the inhibition of tissue factor gene expression in endothelial cells and of its activity by inhibiting allosteric disulfide bond (ADB) formation. ADB in the tissue factor molecule would be a promising molecular target in the development of functional food preventing thrombotic diseases.
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Report
(4 results)
Research Products
(51 results)
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[Presentation] Anti-obesity effect of garlic oil.
Author(s)
T Seki, Y Kagawa, T Hosono, T Ariga，T Watanabe.
Organizer
2014 International Garlic Symposium; Role of Garlic in Cardiovascular Disease Prevention, Metabolic Syndrome and Immunology.
Place of Presentation
California, USA
Related Report
Invited
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