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Elucidation of the anti-thrombotic property of food component and its application for the development of functional food.

Research Project

Project/Area Number 25292077
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Food science
Research InstitutionNihon University

Principal Investigator

SEKI Taiichiro  日本大学, 生物資源科学部, 教授 (20187834)

Co-Investigator(Kenkyū-buntansha) HOSONO Takashi  日本大学, 生物資源科学部, 講師 (80445741)
SHEN Yan  日本大学, 生物資源科学部, 研究員 (80614007)
Research Collaborator YAGUCHI Manami  
OKUE Sachiko  
OKAMOTO Atsushi  
SATO Asuka  
MIURA Atsushi  
NISHIMURA Satoshi  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords食品機能 / 生活習慣病 / 血液凝固 / garlic / thrombosis
Outline of Final Research Achievements

Thrombotic diseases including myocardial infarction and cerebrovascular diseases are the major causes of death. Blood coagulation factor III (tissue factor) is highly expressed on the arteriosclerotic region and triggering thrombotic diseases. In this study, we characterized the tissue factor as molecular target of food factors as well as elucidating novel regulatory mechanism(s) of hemostasis to develop the food function. We demonstrated the anti-thrombotic property of garlic derived component diallyl trisulfide (DATS) at molecular basis. DATS inhibits thrombus formation through the inhibition of tissue factor gene expression in endothelial cells and of its activity by inhibiting allosteric disulfide bond (ADB) formation. ADB in the tissue factor molecule would be a promising molecular target in the development of functional food preventing thrombotic diseases.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (51 results)

All 2016 2015 2014 2013 Other

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (36 results) (of which Int'l Joint Research: 1 results,  Invited: 8 results) Book (4 results)

  • [Journal Article] Prevention of Cardiovascular Diseases by Garlic-Derived Sulfur Compounds2015

    • Author(s)
      Seki T, Hosono T.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 61 Issue: Supplement Pages: S83-S85

    • DOI

      10.3177/jnsv.61.S83

    • NAID

      130005109866

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 血液の凝固・線溶とメタボリックシンドローム,生活習慣病2015

    • Author(s)
      関 泰一郎、細野 崇
    • Journal Title

      化学と生物(日本農芸化学会誌)

      Volume: 53 Pages: 374-380

    • NAID

      130005152089

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 血液の凝固・線溶とメタボリックシンドローム,生活習慣病2015

    • Author(s)
      関 泰一郎、細野 崇
    • Journal Title

      化学と生物

      Volume: 53

    • NAID

      130005152089

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of cardiovascular diseases by garlic-derived sulfur compounds.2015

    • Author(s)
      Taiichiro Seki, Takashi Hosono
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 61

    • NAID

      130005109866

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diallyl trisulfide induces apoptosis in Jurkat cells by the modification of cysteine residues in thioredoxin.2014

    • Author(s)
      Watanabe K, Hosono T, Watanabe K, Hosono-Fukao T, Ariga T, Seki T.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 78(8): Issue: 8 Pages: 1418-1420

    • DOI

      10.1080/09168451.2014.921564

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of molecular target of diallyl trisulfide in leukemic cells.2014

    • Author(s)
      Suda S, Watanabe K, Tanaka Y, Watanabe K, Tanaka R, Ogihara J, Ariga T
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 78(8) Issue: 8 Pages: 1415-1417

    • DOI

      10.1080/09168451.2014.921563

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] TAFI の構造と機能2014

    • Author(s)
      三浦 徳, 細野 崇, 関 泰一郎
    • Journal Title

      日本血栓止血学会誌

      Volume: 25 (4) Pages: 512-515

    • NAID

      130004687767

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes2014

    • Author(s)
      Shen Y, Honma N, Kobayashi K, Jia LN, Hosono T, Shindo K, Ariga T, Seki T.
    • Journal Title

      PLoS One

      Volume: 14;9(2):e87894 Issue: 2 Pages: 1-9

    • DOI

      10.1371/journal.pone.0087894

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diallyl trisulfide induces apoptosis in Jurkat cells by the modification of2014

    • Author(s)
      Kazunari Watanabe, Takashi Hosono, Kazuhiro Watanabe,Tomomi Hosono-Fukao, Toyohiko Ariga,Taiichiro Seki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Molecular Target of Diallyl Trisulfide in Leukemic Cells2014

    • Author(s)
      Shun Suda, Kazunari Watanabe, Yuki Tanaka, Kazuhiro Watanabe, Rie Tanaka, Jun Ogihara, Toyohiko Ariga,Tomomi Hosono-Fukao, Takashi Hosono, Taiichiro Seki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メタロカルボキシペプチダーゼTAFIの線溶抑制機能と病態生理2013

    • Author(s)
      関 泰一郎、三浦 徳、細野 崇
    • Journal Title

      日本血栓止血学会誌

      Volume: 24(5) Pages: 491-495

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 米ぬか由来ステロール配糖体が ApoE 欠損マウスの動脈硬化に及ぼす影響2016

    • Author(s)
      宇田川 賢太、大村妃代、船戸里香、中島有里、奥原康英、太田慶彦、石川純嗣、 細野 崇、関 泰一郎
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック由来香気成分 diallyl trisulfide によるタンパク質分解系を介した第一相薬物代謝酵素 CYP2E1 発現抑制機構の解明2016

    • Author(s)
      荒木彩花、矢口真実、奥江 紗知子、細野 崇、関 泰一郎
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック由来香気成分 diallyl trisulfide の抗炎症作用メカニズムの解明2016

    • Author(s)
      奥江 紗知子、今井孝俊、日吉滉平、荒木彩花、矢口真実、船戸里香、林 浩和、小島 貴之、横山令奈、細野 崇、関 泰一郎
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック由来香気成分が外因系凝固に及ぼす影響2016

    • Author(s)
      矢口真実、荒木彩花、奥江 紗知子、細野 崇、関 泰一郎
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック香気成分がLPS/ガラクトサミン誘導性急性肝炎に及ぼす影響2016

    • Author(s)
      横山令奈、小泉洸太、小島貴之、奥江 紗知子、船戸里香、三浦 徳、細野 崇、関 泰一郎
    • Organizer
      日本食品化学工学会平成28年度関東支部大会(藤沢)
    • Place of Presentation
      日本大学(神奈川・藤沢)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック由来香気成分による CYP2E1 タンパク質発現抑制機構の解明2015

    • Author(s)
      荒木 彩花、矢口 真実、奥江 紗知子、細野 崇、関 泰一郎
    • Organizer
      第30回 日本香辛料研究会
    • Place of Presentation
      龍谷大学(京都府・京都市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック香気成分diallyl trisulfideの抗炎症作用メカニズムの解明2015

    • Author(s)
      奥江 紗知子、今井 孝俊、荒木 彩花、矢口 真実、細野 崇、関 泰一郎
    • Organizer
      第30回 日本香辛料研究会
    • Place of Presentation
      龍谷大学(京都府・京都市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック由来香気成分が血液凝固因子Tissue Factor に及ぼす影響2015

    • Author(s)
      矢口 真実、荒木 彩花、奥江 紗知子、細野 崇、関 泰一郎
    • Organizer
      第30回 日本香辛料研究会
    • Place of Presentation
      龍谷大学(京都府・京都市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diallyl trisulfide prevents the acetaminophen-induced liver injury through the posttranslational regulation of CYP2E1 protein expression.2015

    • Author(s)
      Sayaka Araki, Koji Kimura, Manami Yaguchi, Rika Funado, Sachiko Okue,Takashi Hosono, Taiichiro Seki
    • Organizer
      ICoff2015
    • Place of Presentation
      COEX (Seoul (South Korea))
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diallyl trisulfide inhibits thrombus formation through the inhibition of both platelet aggregation and extrinsic coagulation pathway.2015

    • Author(s)
      Manami Yaguchi, Asuka Sato, Sayaka Araki, Sachiko Okue,Takashi Hosono, Satoshi Nishimura, Taiichiro Seki
    • Organizer
      ICoff2015
    • Place of Presentation
      COEX (Seoul (South Korea))
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effect of diallyl trisulfide, a garlic flavor component, on nonalcoholic steatohepatitis2015

    • Author(s)
      Rika Funado, Hirokazu Hayashi, Sayaka Araki, Manami Yaguchi, Sachiko Okue, Takashi Hosono, Taiichiro Seki
    • Organizer
      ICoff2015
    • Place of Presentation
      COEX (Seoul (South Korea))
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Anti-inflammatory activity of allyl sulfide derived from garlic2015

    • Author(s)
      Sachiko Okue, Takatoshi Imai, Kohei Hiyoshi, Sayaka Araki,Manami Yaguchi, Takashi Hosono, Taiichiro Seki
    • Organizer
      ICoff2015
    • Place of Presentation
      COEX (Seoul (South Korea))
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] ガーリック由来スルフィドの抗血栓作用とそのメカニズムの解明2015

    • Author(s)
      矢口真実、細野 崇、関 泰一郎
    • Organizer
      第37回日本血栓止血学会学術集会
    • Place of Presentation
      甲府市総合市民会館(山梨県・甲府市)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diallyl trisulfide protects the liver from acetaminophen induced intoxication2015

    • Author(s)
      Sayaka Araki, Koji Kimura, Ayano Kugu, Takashi Hosono, Taiichiro Seki
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effect of flavor compounds derived from garlic on thrombus formation2015

    • Author(s)
      Manami Yaguchi, Asuka Sato, Hosono Takashi, Nishimura Satoshi, Taiichiro Seki
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Asian herbal and medicinal food for the prevention of life style-related diseases. In Symposium: Asian Herbal and Medicinal Food for the Prevention of Lifestyle-related Diseases.2015

    • Author(s)
      Seki T
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ガーリック由来香気成分の抗血栓作用の解明2015

    • Author(s)
      矢口真実、細野 崇、関 泰一郎
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山市・岡山大学津島キャンパス
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ガーリック由来香気成分の抗血栓作用とそのメカニズム(YIA授賞)2014

    • Author(s)
      矢口真実、細野 崇、関 泰一郎
    • Organizer
      第19回 日本フードファクター学会(JSoFF2014)
    • Place of Presentation
      鹿児島市・鹿児島大学
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 17th International Congress of Oriental Medicine2014

    • Author(s)
      Taiichiro Seki
    • Organizer
      Herbal and dietary phytochemicals and the prevention of life-style related diseases.
    • Place of Presentation
      台北(台湾)・台北大学国際会議センター
    • Year and Date
      2014-11-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ガーリック由来香気成分が外因系血液凝固に及ぼす影響2014

    • Author(s)
      矢口真実、細野 崇、関 泰一郎
    • Organizer
      第68回日本栄養・食糧学会大会(札幌)
    • Place of Presentation
      札幌市・酪農学園大学
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ガーリック香気成分diallyl trisulfideはαIIbβ3とP-selectin発現と血小板凝集を抑制する2014

    • Author(s)
      細野 崇、佐藤明日香、関 泰一郎
    • Organizer
      第36回日本血栓止血学会学術集会(大阪)
    • Place of Presentation
      大阪・大阪国際会議場
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of TAFI in the liver regeneration: Evidences obtained from animal models.

    • Author(s)
      関 泰一郎
    • Organizer
      第35回日本血栓止血学会学術集会 SPCシンポジウム「線溶と動物モデル」
    • Place of Presentation
      山形(山形国際ホテル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Food function of Garlic, an Essential Ingredient of Kimchi, in the prevention of Life Style-Related Diseases.

    • Author(s)
      Seki T
    • Organizer
      International Kimchi Conference-Health Benefits of Kimchi.
    • Place of Presentation
      The National Folk Museum of Korea, Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Garlic-derived compounds for the prevention of lifestyle-related diseases.

    • Author(s)
      Seki T
    • Organizer
      In Symposium: Phytochemicals responsible for the food function, from the chemistry to physiological relevance and human health. IUNS 20th International Congress of Nutrition.
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Food function of Garlic: from active principle to physiological relevance at molecular basis.

    • Author(s)
      Seki T
    • Organizer
      2013 International Symposium of Condiment Vegetables,
    • Place of Presentation
      Sunchon National University, Sunchon, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 白色脂肪組織において chymase はマクロファージと結合して遊走に関与する

    • Author(s)
      江口 輝、関根 瞳、小林 奈保子、細野 崇、関 泰一郎
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形(山形国際ホテル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガーリックオイルの抗肥満効果とそのメカニズムの解明

    • Author(s)
      香川祐輝、渡邊智之、久宮彩乃、細野 崇、関 泰一郎
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋(名古屋大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] シナモン熱水抽出物は脂肪細胞のACSL1発現量を低下させてエネルギー代謝を亢進させる

    • Author(s)
      沈 燕、小林克也、細野(深尾)友美、細野 崇、関 泰一郎
    • Organizer
      第67回日本栄養・食糧学会大会(名古屋)
    • Place of Presentation
      名古屋(名古屋大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diallyl trisulfideによるマクロファージのNO産生抑制メカニズム

    • Author(s)
      今井孝俊、渡辺師成、細野 崇、関 泰一郎
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋(名古屋大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガーリックオイルの抗肥満効果に関する研究

    • Author(s)
      香川 祐輝、久宮 彩乃、秋葉 知奈、山口 花梨、細野 崇、関 泰一郎
    • Organizer
      第18回 日本フードファクター学会学術集会 JSoFF2013
    • Place of Presentation
      東京(東京農業大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガーリック由来香気成分 diallyl trisulfide によるインテグリンαIIbβIIIとP-selectin の発現抑制と血小板の凝集抑制効果について

    • Author(s)
      佐藤明日香、細野崇、関 泰一郎
    • Organizer
      第28回日本香辛料研究会
    • Place of Presentation
      千葉(三井アーバンホテル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガーリック由来香気成分diallyl trisulfide (DATS) の抗がん作用メカニズムの解明―DATS がthioredoxinのシステイン残基に及ぼす影響―

    • Author(s)
      渡辺師成、今井孝俊、日吉滉平、細野 崇、関 泰一郎
    • Organizer
      第28回日本香辛料研究会
    • Place of Presentation
      千葉(三井アーバンホテル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 時間制限摂食は肝臓脂質量を変化させ体重増加に影響を及ぼす

    • Author(s)
      大路拓巳、細野 崇、関 泰一郎
    • Organizer
      日本栄養・食糧学会関東支部第93回シンポジウムと日本食品科学工学会平成26年度関東支部大会の合同大会(最優秀賞 受賞)
    • Place of Presentation
      東京(東京農業大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガーリックオイルは脂質酸化を促進して肥満を改善する

    • Author(s)
      香川 祐輝、細野 崇、関 泰一郎
    • Organizer
      日本栄養・食糧学会関東支部第93回シンポジウムと日本食品科学工学会平成26年度関東支部大会の合同大会 (優秀賞 受賞)
    • Place of Presentation
      東京(東京農業大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-obesity effect of garlic oil.

    • Author(s)
      T Seki, Y Kagawa, T Hosono, T Ariga,T Watanabe.
    • Organizer
      2014 International Garlic Symposium; Role of Garlic in Cardiovascular Disease Prevention, Metabolic Syndrome and Immunology.
    • Place of Presentation
      California, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Diallyl trisulfide, a flavor component of garlic, inhibits the platelet aggregation through the suppression of Akt phosphorylation.

    • Author(s)
      T Hosono, A Sato,T Seki
    • Organizer
      2014 International Garlic Symposium; Role of Garlic in Cardiovascular Disease Prevention, Metabolic Syndrome and Immunology.
    • Place of Presentation
      California, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Functional Foods, Nutraceuticals and Natural Products-Concepts and applications (Vattem D.A., Maitin V Edts)2016

    • Author(s)
      Seki T, Hosono T, Kumagai H, Ariga T
    • Total Pages
      820
    • Publisher
      DEStech Publications, Inc. USA, 2016
    • Related Report
      2015 Annual Research Report
  • [Book] 新・血栓止血血管学:抗凝固と線溶2015

    • Author(s)
      関 泰一郎、三浦 徳
    • Total Pages
      133
    • Publisher
      金芳堂
    • Related Report
      2015 Annual Research Report
  • [Book] 食品因子による栄養機能制御2015

    • Author(s)
      関 泰一郎、細野 崇
    • Total Pages
      283
    • Publisher
      建帛社
    • Related Report
      2015 Annual Research Report
  • [Book] 食品因子による栄養機能制御2015

    • Author(s)
      関 泰一郎、細野 崇
    • Publisher
      建帛社
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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