Improving effect of brain function by phycoerythlin from red algae and clarification of its mechanism
| Project/Area Number |
25292121
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Aquatic life science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KISHIMURA HIDEKI 北海道大学, 水産科学研究科(研究院), 准教授 (50204855)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
足立 亨介 高知大学, 自然科学系, 准教授 (00399114)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Keywords | 紅藻 / ダルス / フィコビリタンパク質 / フィコエリスリン / 抗酸化作用 / 脳機能改善 / 促進老化モデルマウス / 次世代シーケンス / トランスクリプトーム解析 |
|---|
| Outline of Final Research Achievements |
We studied the improving effect of brain function by “phycoerythlin (PE)” from the red alga dulse (Palmaria palmata) using the senescence-accelerated mouse prone-10 (SAMP10). It was clarified that dulse PE shows antioxidative effect and the active factor is its chromophore. Then, by long-term administration of dulse PE to SAMP10, the deterioration of circadian rhythm depending on aging of SAMP10 was significantly restrained. In addition, the spatial perception of SAMP10 was significantly maintained by long-term administration of dulse PE. It was thought that these effects were derived from a reduction of oxidative stress in SAMP10 by dulse PE.
|
Report
(5 results)
Research Products
(18 results)
