• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Brain mechanisms underlying differences between male and female teleosts

Research Project

Project/Area Number 25292124
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Aquatic life science
Research InstitutionThe University of Tokyo

Principal Investigator

Okubo Kataaki  東京大学, 農学生命科学研究科, 准教授 (10370131)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords水産学 / 生理学 / 神経科学
Outline of Final Research Achievements

Teleost fish exhibit marked sex differences in a wide range of traits, including aggressive and reproductive behavior, growth, sexual maturation, and stress response. However, it remains to be elucidated what mechanisms in the teleost brain underlie these sex differences. In the present study, we have identified a novel teleost-specific gene that is expressed in the brain and presumably involved in stress response, and named it teleocortin. We have also provided the evidence that glucocorticoid receptor 1 expressed in the preoptic area most likely plays an important role in behavioral sex differences.

Report

(4 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Teleocortin: A novel member of the corticotropin-releasing hormone family in teleost fish.2015

    • Author(s)
      Hosono K, Kikuchi Y, Miyanishi H, Hiraki-Kajiyama T, Takeuchi A, Nakasone K, Maehiro S, Okubo K
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 8 Pages: 2949-2957

    • DOI

      10.1210/en.2015-1042

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glucocorticoid receptor exhibits sexually dimorphic expression in the medaka brain.2015

    • Author(s)
      Kikuchi Y, Hosono K, Yamashita J, Kawabata Y, Okubo K.
    • Journal Title

      General and comparative endocrinology

      Volume: 223 Pages: 4753-4753

    • DOI

      10.1016/j.ygcen.2015.09.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuropeptide B is female-specifically expressed in the telencephalic and preoptic nuclei of the medaka brain.2014

    • Author(s)
      Hiraki T, Nakasone K, Hosono K, Kawabata Y, Nagahama Y, Okubo K.
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 3 Pages: 1021-1032

    • DOI

      10.1210/en.2013-1806

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-proliferative immature radial glial cells female-specifically express aromatase in the medaka optic tectum2013

    • Author(s)
      Takeuchi A, Okubo K
    • Journal Title

      PLoS One

      Volume: 8 Issue: 9 Pages: e73663-e73663

    • DOI

      10.1371/journal.pone.0073663

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Steroid hormones and sexual plasticity of the brain2015

    • Author(s)
      Okubo K
    • Organizer
      日本動物学会第86回大会(シンポジウム What is the next target for research in comparative endocrinology?)
    • Place of Presentation
      新潟コンベンションセンター朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メダカの脳におけるグルココルチコイド受容体:発現の性差と行動・神経内分泌関連遺伝子との共発現2015

    • Author(s)
      菊池結貴子・大久保範聡
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都港区)
    • Year and Date
      2015-03-27 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] メダカの下垂体におけるトリプトファン水酸化酵素遺伝子の性差と発現制御機構2015

    • Author(s)
      川幡由希香・菊池結貴子・大久保範聡
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都港区)
    • Year and Date
      2015-03-27 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Estrogen produced by the ovary stimulates the meninges to express a novel heme-binding protein gene, hebp3, in a female-biased manner in medaka2014

    • Author(s)
      Nakasone K, Yamashita J, Okubo K
    • Organizer
      10th International Symposium on Reproductive Physiology of Fish
    • Place of Presentation
      Olhao (Portugal)
    • Year and Date
      2014-05-26 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 魚類の脳の性成熟機構に関する研究2013

    • Author(s)
      大久保範聡
    • Organizer
      平成25年度(第12回)日本農学進歩賞受賞者講演会
    • Place of Presentation
      東京都文京区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 魚類の脳における性分化2013

    • Author(s)
      大久保範聡
    • Organizer
      第38回日本比較内分泌学会大会・第40回日本神経内分泌学会学術集会
    • Place of Presentation
      宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] メダカの脳内でメスのみに存在する性ステロイド受容性ニューロンの性的可逆性2013

    • Author(s)
      横山圭子、大久保範聡
    • Organizer
      第38回日本比較内分泌学会大会・第40回日本神経内分泌学会学術集会
    • Place of Presentation
      宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカの脳内で発現に性差を示す遺伝子のノックアウトメダカの作出2013

    • Author(s)
      外川理絵、大久保範聡
    • Organizer
      第38回日本比較内分泌学会大会・第40回日本神経内分泌学会学術集会
    • Place of Presentation
      宮崎県宮崎市
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカの脳におけるメス特異的な性ステロイド受容体の発現は性成熟オスでも誘導され得る2013

    • Author(s)
      山下純平、大久保範聡
    • Organizer
      第38回日本比較内分泌学会大会・第40回日本神経内分泌学会学術集会
    • Place of Presentation
      宮崎県宮崎市
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi