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The analysis of interaction of chemerin and other adipokines in bovine fat accumulation and lipid metabolim

Research Project

Project/Area Number 25292158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Animal production science
Research InstitutionTohoku University

Principal Investigator

ROH SANGGUN  東北大学, (連合)農学研究科(研究院), 准教授 (90322130)

Co-Investigator(Kenkyū-buntansha) SUZUKI Kei-ichi  東北大学, 大学院農学研究科, 教授 (10344706)
Nakajima Kei-ichi  国立研究開発法人 農業・食品産業技術総合研究機構, 主任研究員 (70362150)
HAGINO Akihiko  東北大学, 大学院農学研究科, 助教 (80156249)
HAGA Satoshi  国立研究開発法人 農業・食品産業技術総合研究機構, 研究員 (90442748)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywordsウシ / Chemerin / Weaning / Lactation dairy cattle / ケメリン / 乳腺組織 / 肝臓組織 / 肝細胞 / 乳腺細胞 / 脂質代謝 / 脂肪蓄積
Outline of Final Research Achievements

This study was aimed to elucidate the physiological function of chemerin in the metabolism transitional period of weaning and lactating dairy cattle. Protein expression of Chemerin in the liver was reduced after weaning, but chemerin regulated the gluconeogenesis by propionic acid in the liver without the regulation of insulin secretion in the weaning period. Chemerin gene expression and secretion was reduced in liver of dairy cows after delivery, but this change is directly related with the regulation hepatic gluconeogenesis. This results suggest that the expression and secretion of chemerin in cattle dynamically changes the metabolism transition and revealed to be involved in the regulation of lipid metabolism or glucose metabolism.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (38 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (6 results) Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 7 results,  Acknowledgement Compliant: 6 results) Presentation (18 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] National Institute of Animal Science/Rural development Administration(韓国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] North Carolina State University(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Muchen Technical University(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Department of Biomedical Science(オーストラリア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Physiological roles of adipokines, hepatokines, and myokines in ruminants.2016

    • Author(s)
      Sang-Gun Roh, Yutaka Suzuki, Takaufmi Gotoh, Ryuichi Tatsumi, Kazuo Katoh
    • Journal Title

      Asian-Australasian Journal of Animal Sciences

      Volume: 29 Issue: 1 Pages: 1-15

    • DOI

      10.5713/ajas.16.0001r

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single Nucleotide Polymorphism in the Coding Region of Bovine Chemerin Gene and Their Associations with Carcass Traits in Japanese Black Cattle2015

    • Author(s)
      Yamauchi E, Suzuki Y, So KH, Suzuki K, Katoh K and Roh SG
    • Journal Title

      Asian-Australasian Journal of Animal Sciences

      Volume: 印刷中 Issue: 8 Pages: 1084-1089

    • DOI

      10.5713/ajas.14.0560

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soluble extract of soybean fermented with Aspergillus oryzae GB107 inhibits fat accumulation in cultured 3T3-L1 adipocytes2015

    • Author(s)
      So KH, Suzuki Y, Yonekura S, Suzuki Y, Lee CH, Kim SW, Katoh K, Roh SG
    • Journal Title

      Nutrition Research and Practice

      Volume: 9(4) Issue: 4 Pages: 439-444

    • DOI

      10.4162/nrp.2015.9.4.439

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression of α-tocopherol-associated genes and α-tocopherol accumulation in Japanese Black (Wagyu) calves with and without α-tocopherol supplementation2015

    • Author(s)
      Haga S, Nakano M, Ishizaki H, Roh SG, Katoh K
    • Journal Title

      Journal of Animal Science.

      Volume: 93 Issue: 8 Pages: 4048-4057

    • DOI

      10.2527/jas.2015-9106

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chemerin is a novel regulator of lactogenesis in bovine mammary epithelial cells2015

    • Author(s)
      Suzuki Y, Haga S, Katoh D, So KH, Choi KC, Jung US, Lee HG, Kazuo K, Roh SG
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 466 Issue: 3 Pages: 283-288

    • DOI

      10.1016/j.bbrc.2015.08.105

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 反芻動物におけるヘパトカインとしてのChemerinとANGPTL8の発現調節2015

    • Author(s)
      鈴木裕、中野美智、芳賀聡、中島恵一、加藤和雄、盧尚建
    • Journal Title

      家畜栄養生理研究会会報

      Volume: 59 Pages: 59-68

    • NAID

      40020646494

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The regulation of oxytocin receptor gene expression during adipogenesis2015

    • Author(s)
      Yi KJ, So KH, Hata Y, Suzuki Y, Kato D, Watanabe K, Aso H, Kasahara Y, Nishimori K, Chen C, Katoh K, Roh SG
    • Journal Title

      J Neuroendocrinology

      Volume: 27 Issue: 5 Pages: 335-342

    • DOI

      10.1111/jne.12268

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The effect of single nucleotide polymorphisms in GH gene promoter region on carcass traits and intramuscular fatty acid compositions in Japanese Black cattle2014

    • Author(s)
      Sugita H, Ardiyanti A, Yokota S, Yonekura S, Hirayama H, Shoji N, Yamauchi E, Suzuki K, Katoh K, Roh SG
    • Journal Title

      Livestock Science 165:15-21

      Volume: 165 Pages: 15-21

    • DOI

      10.1016/j.livsci.2014.04.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased plasma ghrelin suppresses insulin release in wethers fed with a high protein diet.2014

    • Author(s)
      Takahashi T, Sato K, Kato S, Yonezawa T, Kobayashi Y, Ohtani Y, Owada S, Aso H, Yamaguchi T, Roh SG, Katoh K
    • Journal Title

      J Endocrinology

      Volume: 221(3) Issue: 3 Pages: 371-380

    • DOI

      10.1530/joe-13-0501

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Individual difference in serum oxytocin concentraions of calves and the correlation with those in dams2014

    • Author(s)
      Chen S, Tanaka S, Oyakawa C, Roh SG, Satoh S.
    • Journal Title

      Animal Science Journal

      Volume: 85 Issue: 1 Pages: 53-57

    • DOI

      10.1111/asj.12082

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actions of intravenous injections of AVP and oxytocin on plasma ACTH, GH, insulin, and glucagon concentrations in goats2014

    • Author(s)
      Roh SG, Koiwa K, Sato K, Ohtani Y, Takahashi T, Katoh K
    • Journal Title

      Animal Science Journal

      Volume: 85 Pages: 286-292

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and In vivo enhancement of adipogenesis by italian ryegrass (Lolium Multiflorum) in 3T3-L1 cells and mice2014

    • Author(s)
      Valan M, Ilavenil S, Kim DH, Roh SG, Lee JC, Choi KC.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 1 Pages: e85297-e85297

    • DOI

      10.1371/journal.pone.0085297

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 反芻動物の糖脂質代謝系におけるChemerinの生理的作用機構と生産性との関連2013

    • Author(s)
      鈴木 裕、北山 峻、山内 恵利、宋 相憲、加藤 和雄、盧 尚建.
    • Journal Title

      家畜栄養生理研究会

      Volume: 57 Pages: 45-54

    • NAID

      40019715020

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout Mice.2013

    • Author(s)
      Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, and Nishimori
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 11 Pages: 4305-4315

    • DOI

      10.1210/en.2012-2206

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 離乳前後の仔牛の肝臓組織における網羅的トランスクリプトーム解析2016

    • Author(s)
      盧 尚建、近藤 光彦、鈴木 裕、加藤 大地、芳賀 聡、川原 玲香、河野 友宏、鈴木 啓一、加藤 和雄
    • Organizer
      第121回大会 日本畜産学会
    • Place of Presentation
      日本獣医生命大学(東京都武蔵野市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 黒毛和種牛のルーメン発達関連因子の解析2016

    • Author(s)
      加藤 大地、鈴木 裕、芳賀 聡、蘇 敬夏、川原 玲香、河野 友宏、加藤 和雄、盧 尚建
    • Organizer
      第121回大会 日本畜産学会
    • Place of Presentation
      日本獣医生命大学(東京都武蔵野市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳牛における内分泌因子ケメリンのシグナル調節と役割2015

    • Author(s)
      鈴木裕、中島恵一、芳賀聡、中野美和、宮地慎、石崎宏、盧尚建
    • Organizer
      第120回大会 日本畜産学会
    • Place of Presentation
      酪農学院大学(江別市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 周産期の肝臓組織におけるANGPTL8の発現調節2015

    • Author(s)
      中野美智、鈴木裕、芳賀聡、中野美和、宮地慎、石崎宏、蘇敬夏、加藤和雄、盧尚建
    • Organizer
      第120回大会 日本畜産学会
    • Place of Presentation
      酪農学院大学(江別市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Insulin as a suppressive factor of GH release in the ruminant2015

    • Author(s)
      Katoh K, Kobayashi R, Nishihara K, Suzuki Y, Suzuki K, Roh SG.
    • Organizer
      66th EAAP ANNUAL MEETING
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expressional Regulation of Chemerin and Its Receptors in the Liver and Adipose Tissues of Young Cattle by Weaning and Nutrition2015

    • Author(s)
      Suzuki Y, Kato D, Kondo M, Hatanaka H, Haga S, Gotoh T, Roh SG.
    • Organizer
      2015 ADSA-ASAS Joint Annual Meeting
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RNA-Seqによる黒毛和種牛ルーメン発達関連遺伝子の網羅的トランスクリプトーム解析2015

    • Author(s)
      加藤 大地、鈴木 裕、芳賀 聡、蘇 敬夏、中野 美和、石崎 宏、河野 友宏、加藤 和雄、盧 尚建
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシ培養肝細胞におけるケメリン調節因子に関する研究2015

    • Author(s)
      近藤 光彦、鈴木裕、芳賀 聡、畑中 陽弦、加藤大地、蘇 敬夏、加藤和雄、盧 尚建
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシ乳腺上皮細胞におけるケメリンの糖・脂質代謝関連遺伝子発現の調節作用2015

    • Author(s)
      加藤 大幾、鈴木 裕、芳賀 聡、蘇 敬夏、Hong-Gu Lee、U-Suk Jung、加藤 和雄、盧 尚建
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 反芻動物の採食に伴う成長ホルモン分泌抑制に関する研究2015

    • Author(s)
      小林 涼子、西原 昂来、盧 尚建、加藤 和雄
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Digital Differential Displayによるウシルーメン発達関連遺伝子のIn silico同定2014

    • Author(s)
      加藤 大地、鈴木 裕、芳賀 聡、蘇 敬夏、中野 美和、石崎 宏、 加藤 和雄、盧 尚建
    • Organizer
      第20回Hindgut Club Japanシンポジウム
    • Place of Presentation
      専修大学、東京都
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 絶食・再給餌によるマウス肝臓および脂肪組織におけるケメリンの発現調節2014

    • Author(s)
      鈴木 裕、蘇 敬夏、畑 優紀、熊谷 優希、加藤 和雄、盧 尚建
    • Organizer
      第48回日本栄養・食糧学会東北支部大会および公開シンポジウム
    • Place of Presentation
      東北大学、仙台市
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gene Expression and Regulation of Betatrophin in Cultured Hepatocytes of Preweaning and Postweaning Calves2014

    • Author(s)
      Roh SG, Yamauchi E, Suzuki Y, Kitayama S, Kondo M, Nakano M, Ishizaki H, Haga S, K. Katoh
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chemerin mRNA expression is regulated by insulin and fatty acids in the liver of calves2014

    • Author(s)
      Suzuki Y, Kitayama S, Kondo M, Haga S, Katoh K, Roh SG
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tissues Distribution and Expression Changes of the -tocopherol Related Genes Due to Short Term High Dose Oral Administration of -tocopherol in Weaned Beef Calves2014

    • Author(s)
      Haga S, Nakano M, Ishizaki H, Roh SG, Katoh K
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Postprandial reduction in plasma GH concentration is caused by insulin in goats2014

    • Author(s)
      Kobayashi R, Harjanti DW, Sano H, Roh SG, Katoh K
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシBetatropinの発現と調節2014

    • Author(s)
      山内 恵利、鈴木 裕、蘇 敬夏、芳賀聡、加藤和雄、盧 尚建
    • Organizer
      日本畜産学会第178回大会
    • Place of Presentation
      茨城県、つくば市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 黒毛和種牛の内分泌変化と糖代謝に及ぼすGH多型の影響2013

    • Author(s)
      小林諒子、Harjanti D.W.、盧尚建、佐野 宏明、加藤和雄
    • Organizer
      日本畜産学会第177回大会
    • Place of Presentation
      新潟大学
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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