The analysis of interaction of chemerin and other adipokines in bovine fat accumulation and lipid metabolim
| Project/Area Number |
25292158
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Tohoku University |
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Principal Investigator |
ROH SANGGUN 東北大学, (連合)農学研究科(研究院), 准教授 (90322130)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kei-ichi 東北大学, 大学院農学研究科, 教授 (10344706)
Nakajima Kei-ichi 国立研究開発法人 農業・食品産業技術総合研究機構, 主任研究員 (70362150)
HAGINO Akihiko 東北大学, 大学院農学研究科, 助教 (80156249)
HAGA Satoshi 国立研究開発法人 農業・食品産業技術総合研究機構, 研究員 (90442748)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | ウシ / Chemerin / Weaning / Lactation dairy cattle / ケメリン / 乳腺組織 / 肝臓組織 / 肝細胞 / 乳腺細胞 / 脂質代謝 / 脂肪蓄積 |
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| Outline of Final Research Achievements |
This study was aimed to elucidate the physiological function of chemerin in the metabolism transitional period of weaning and lactating dairy cattle. Protein expression of Chemerin in the liver was reduced after weaning, but chemerin regulated the gluconeogenesis by propionic acid in the liver without the regulation of insulin secretion in the weaning period. Chemerin gene expression and secretion was reduced in liver of dairy cows after delivery, but this change is directly related with the regulation hepatic gluconeogenesis. This results suggest that the expression and secretion of chemerin in cattle dynamically changes the metabolism transition and revealed to be involved in the regulation of lipid metabolism or glucose metabolism.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] The regulation of oxytocin receptor gene expression during adipogenesis2015
Author(s)
Yi KJ, So KH, Hata Y, Suzuki Y, Kato D, Watanabe K, Aso H, Kasahara Y, Nishimori K, Chen C, Katoh K, Roh SG
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Journal Title
J Neuroendocrinology
Volume: 27
Issue: 5
Pages: 335-342
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Increased plasma ghrelin suppresses insulin release in wethers fed with a high protein diet.2014
Author(s)
Takahashi T, Sato K, Kato S, Yonezawa T, Kobayashi Y, Ohtani Y, Owada S, Aso H, Yamaguchi T, Roh SG, Katoh K
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Journal Title
J Endocrinology
Volume: 221(3)
Issue: 3
Pages: 371-380
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout Mice.2013
Author(s)
Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, and Nishimori
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Journal Title
Endocrinology
Volume: 154
Issue: 11
Pages: 4305-4315
DOI
Related Report
Peer Reviewed
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