• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Cattle Production System by Metabolic Programming: Metabolic Regulation System during Fetus and Neonate

Research Project

Project/Area Number 25292162
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Animal production science
Research InstitutionKyushu University

Principal Investigator

GOTOH TAKAFUMI  九州大学, (連合)農学研究科(研究院), 准教授 (70294907)

Research Collaborator TAKAHASHI Hideyuki  
Albrecht Elke  
MAAK Steffen  
PFFAFL Michael  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords代謝プログラミング / 牛 / 効率的飼養 / 粗飼料肥育 / 畜産学 / ウシ / 栄養・飼料 / 栄養 / 動物生産
Outline of Final Research Achievements

Recent research has discovered a unique phenomenon referred to as ‘fetus and neonatal programming’, which is based on ‘the developmental origins of health and disease (DOHaD)’ concept. These studies have shown that alterations in fetus and early postnatal nutrition and endocrine status may result in developmental adaptations that permanently change the structure, physiology and metabolism of affected animals during adult life. The timing of the perturbation in maternal nutrient availability plays an important role in determining the effect that the fetal and neonatal programming have on the developing placenta or fetus and offspring performance. In this study about Japanese Black cattle, it was suggested that there might be strong effects of maternal and neonatal nutrition on the meat quality and quantity.

Academic Significance and Societal Importance of the Research Achievements

本研究課題の学術的意義や社会的意義として、①エピジェネティクスの応用: 代謝プログラミングは、エピジェネティクスの概念を基盤として、遺伝子の発現を栄養によって調整する技術であり、黒毛和牛の肉質や体質に長期的な影響を与えることができるメカニズムの一端を解明したこと。次に②本研究課題から開発される飼養技術により、輸入飼料に過度に依存しない、国土の植物資源を活用した革新的な飼養システムの構築が可能となることを証明したこと。それは環境負荷を軽減し、持続可能な和牛肉生産を可能とすることになる。このように本研究成果は、科学的な革新と持続可能な農業の両立を目指す重要な取り組みとして意義がある。

Report

(3 results)
  • 2016 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (16 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (11 results) (of which Invited: 6 results)

  • [Journal Article] Potential of the application of epigenetics in animal production.2015

    • Author(s)
      Gotoh, T.
    • Journal Title

      Animal Production Science

      Volume: 55 Issue: 2 Pages: 145-158

    • DOI

      10.1071/an14467

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meat Produced by Japanese Black Cattle and Wagyu.2014

    • Author(s)
      Gotoh, T., H. Takahashi, T. Nishimura, K. Kuchida, H. Mannen.
    • Journal Title

      Animal Frontiers

      Volume: 4 Pages: 46-54

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 代謝インプリンティングを基盤とした子牛の成長と産肉性2014

    • Author(s)
      後藤貴文
    • Journal Title

      家畜感染症学会報

      Volume: 3 Pages: 129-138

    • NAID

      40020695568

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Fatty acid profiles and adipogenic gene expression of various fat depots in Japanese Black and Holstein steers2014

    • Author(s)
      B. Shirouchi, E Albrecht, G Nuernberg, S Maak, S Olavanh, Y Nakamura, M Sato, T Gotoh, K Nuernberg
    • Journal Title

      Meat Science

      Volume: 96 Issue: 1 Pages: 157-164

    • DOI

      10.1016/j.meatsci.2013.06.027

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of nutrient intake on intramuscular glucose metabolism during the early growth stage in cross-bred steers (Japanese Black male × Holstein female).2013

    • Author(s)
      Ebara F., S. Inada, M. Morikawa, S. Asaoka, Y. Isozaki, A. Saito, T. Etoh, Y. Shiotsuka, S. G. Roh , J. Wegner and T. Gotoh.
    • Journal Title

      Journal of Animal Physiology and Animal Nutrition

      Volume: 97 Issue: 4 Pages: 684-693

    • DOI

      10.1111/j.1439-0396.2012.01310.x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 代謝インプリンティングによる良質赤身肉生産への挑戦2014

    • Author(s)
      後藤貴文
    • Organizer
      平成26年度 事業化を加速する産学連携支援事業「新たな肉用牛生産シンポジウム ~低コスト・省力的な良質牛肉の生産を目指して~」
    • Place of Presentation
      佐賀市
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 代謝インプリンティングを基盤とした子牛の成長と産肉性2014

    • Author(s)
      後藤貴文
    • Organizer
      第4回 家畜感染症学会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Influence of Different Nutrients and Feeding Amount of Milk Replacer on Growth and Physiological Aspects in Wagyu (Japanese Black ) Calves.2014

    • Author(s)
      Gotoh,T., H. Terao, K. Etoh, S. Khounsaknalath, K. Saito, K. Sakuma, T. Abe, T. Etoh, Y. Shiotsuka, A .Saito, H. Takahashi, M. Furuse.
    • Organizer
      The 16th Asian-Australasian Association of Animal Production Societies (AAAP)
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Potential of epigenetics (application) for meat production of Japanese Black cattle.2014

    • Author(s)
      Gotoh, T.
    • Organizer
      Hanwoo Experiment Station International Symposium- Novel application to improve Hanwoo meat quality and quantity
    • Place of Presentation
      Daegwallyeong Pyeongchang, Korea
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The potential of epigenetics (Application) for animal production.2014

    • Author(s)
      Gotoh, T.
    • Organizer
      the 1st Joint symposium on the nutrition of herbivores/International Symposium on Ruminant Physiology
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] High nutrition during early growth stage affect expressions of fatty acid synthesis, stearoyl-CoA desaturase and leptin in Longissimus muscle of Wagyu by metabolic imprinting.2014

    • Author(s)
      Khounsaknalath Sithyphone , Saito Kunihiko, Sakuma Kaori , Abe Tsuyoshi, Saito Akira, Tetsuji Etoh, Shiotsuka Yuji, Takahashi Hideyuki , Takafumi Gotoh.
    • Organizer
      High nutrition during early growth stage affect expressions of fatty acid synthesis, stearoyl-CoA desaturase and leptin in Longissimus muscle of Wagyu by metabolic imprinting.
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 粗飼料肥育の黒毛和種における初期栄養が筋内細胞外マトリックスに与える影響2014

    • Author(s)
      野村碧・齋藤邦彦・佐久間香織・増田恭久・岡田真人・阿部剛・小林栄治・鈴木英敏・金田修一・塩塚雄二・藤村亮佑・衛藤哲次・髙橋秀之・後藤貴文
    • Organizer
      第118回日本畜産学会
    • Place of Presentation
      茨城県筑波市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Metabolic imprinting effect during Early Growth on Extra Cellular Matrix Construction in Wagyu (Japanese Black Steers).2013

    • Author(s)
      A. Nomura, R. Fujimura, A. Saito, S. Khounsakunalath, K. Saito, K. Sakuma, T. Abe, H. Hasebe, S. Kaneda, T. Etoh, Y. Shiotsuka, S. Maak, E. Albrecht, H. Takahashi, and T. Gotoh.
    • Organizer
      2013 ADSA-ASAS Joint Annual Meeting
    • Place of Presentation
      Indianapolis, Indiana, USA.
    • Related Report
      2013 Annual Research Report
  • [Presentation] A. Nomura, R. Fujimura, S. Khounsakunalath, K. Saito, K. Sakuma, T. Abe, S. Kaneda, T. Etoh, Y. Shiotsuka, H. Takahashi, and T. Gotoh.2013

    • Author(s)
      Metabolic imprinting effect during Early Growth on Extra Cellular Matrix Construction in Japanese Black Steers.
    • Organizer
      8th World Congress on Developmental Origins of Health and Disease.
    • Place of Presentation
      Singapore.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Metabolic Imprinting Effect in Beef Production: Influence of Nutrition Manipulation during an Early Growth Stage on PPARγ2 and PMRT5 Expressions in the Longissimus Muscle in Wagyu (Japanese Black)2013

    • Author(s)
      S Khounsaknalath, R Fujimura, K Etoh , K Saito, K Sakuma, K Kaneda, T Abe, T Etoh, Y Shiotsuka, H Hasebe, H Hasebe, S Maak, A Elke, H Takahashi, A. Saito, T Gotoh
    • Organizer
      The 8th Developmental Origins of Health and Disease (DOHaD)
    • Place of Presentation
      Singapore.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Metabolic Imprinting Effect in Beef Production: Influence of Nutrition Manipulation during an Early Growth Stage on Adipogenesis in the Longissimus Muscle in Wagyu (Japanese Black)2013

    • Author(s)
      Fujimura, R, K. Etoh, S. Khounsaknalath, K. Saito, K. Metoki, S. Kaneda, T. Abe, T. Etoh, Y. Shiotsuka , H.Suzuki, H. Hasebe, F. Ebara, S. Maak, E. Albrecht, A .Saito and T. Gotoh
    • Organizer
      2013 ADSA-ASAS Joint Annual Meeting
    • Place of Presentation
      Indianapolis, Indiana, USA.
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2025-03-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi