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Fattening and evaluation of Japan Japanese Black Cattle selected on the basis of the fat metabolism-related gene mutation

Research Project

Project/Area Number 25292163
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Animal production science
Research InstitutionTohoku University

Principal Investigator

KATOH KAZUO  東北大学, (連合)農学研究科(研究院), 教授 (60091831)

Co-Investigator(Kenkyū-buntansha) HIRAYAMA Takujie  滋賀県立大学, 環境科学部, 准教授 (00274887)
ROH Sanggun  東北大学, 大学院農学研究科, 准教授 (90322130)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords黒毛和種牛 / 脂肪蓄積 / 成長ホルモン / 遺伝子多型 / メタン放出
Outline of Final Research Achievements

This study was to conduct the fattening evaluation by characterizing the fat accumulation and endocrine regulation in single nucleotide polymorphism of bovine growth hormone (bGH). (1) GH gene polymorphism changed the oleic acid composition in the intramuscular fat by regulating the SCD-1. (2) Response to GH stimulation was different depending on the GH genotype. (3)Insulin has an action to suppress the secretion of GH acts directly on the anterior pituitary, GH secretion is increased by changes in stress and NEFA concentrations caused by the sharp reduction in blood glucose levels in vivo. These results indicate that endocrine regulations such as insulin may different by GH polymorphism of Japanese Black Cattle, affecting the meat quality and production due to changes in fat accumulation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Physiological roles of adipokines, hepatokines, and myokines in ruminants.2016

    • Author(s)
      Sang-Gun Roh, Yutaka Suzuki, Takaufmi Gotoh, Ryuichi Tatsumi, Kazuo Katoh
    • Journal Title

      Asian-Australasian Journal of Animal Sciences

      Volume: 29 Issue: 1 Pages: 1-15

    • DOI

      10.5713/ajas.16.0001r

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single Nucleotide Polymorphism in the Coding Region of Bovine Chemerin Gene and Their Associations with Carcass Traits in Japanese Black Cattle2015

    • Author(s)
      Yamauchi E, Suzuki Y, So KH, Suzuki K, Katoh K and Roh SG
    • Journal Title

      Asian-Australasian Journal of Animal Sciences

      Volume: 印刷中 Issue: 8 Pages: 1084-1089

    • DOI

      10.5713/ajas.14.0560

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemerin is a novel regulator of lactogenesis in bovine mammary epithelial cells2015

    • Author(s)
      Suzuki Y, Haga S, Katoh D, So KH, Choi KC, Jung US, Lee HG, Kazuo K, Roh SG
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 466 Issue: 3 Pages: 283-288

    • DOI

      10.1016/j.bbrc.2015.08.105

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The regulation of oxytocin receptor gene expression during adipogenesis2015

    • Author(s)
      Yi KJ, So KH, Hata Y, Suzuki Y, Kato D, Watanabe K, Aso H, Kasahara Y, Nishimori K, Chen C, Katoh K, Roh SG
    • Journal Title

      J Neuroendocrinology

      Volume: 27 Issue: 5 Pages: 335-342

    • DOI

      10.1111/jne.12268

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The effect of single nucleotide polymorphisms in GH gene promoter region on carcass traits and intramuscular fatty acid compositions in Japanese Black cattle2014

    • Author(s)
      Sugita H, Ardiyanti A, Yokota S, Yonekura S, Hirayama H, Shoji N, Yamauchi E, Suzuki K, Katoh K, Roh SG
    • Journal Title

      Livestock Science 165:15-21

      Volume: 165 Pages: 15-21

    • DOI

      10.1016/j.livsci.2014.04.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased plasma ghrelin suppresses insulin release in wethers fed with a high protein diet.2014

    • Author(s)
      Takahashi T, Sato K, Kato S, Yonezawa T, Kobayashi Y, Ohtani Y, Owada S, Aso H, Yamaguchi T, Roh SG, Katoh K
    • Journal Title

      J Endocrinology

      Volume: 221(3) Issue: 3 Pages: 371-380

    • DOI

      10.1530/joe-13-0501

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes2014

    • Author(s)
      Yonekura S, Hirota S, Tokutake Y, Rose MT, Katoh K, Aso H
    • Journal Title

      Asian-Australas J Anim Sci.

      Volume: 27(4) Issue: 4 Pages: 567-573

    • DOI

      10.5713/ajas.2013.13559

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Actions of intravenous injections of AVP and oxytocin on plasma ACTH, GH, insulin, and glucagon concentrations in goats2014

    • Author(s)
      Roh SG, Koiwa K, Sato K, Ohtani Y, Takahashi T, Katoh K.
    • Journal Title

      Animal Science Journal

      Volume: 85 Pages: 286-292

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms and protein structures in growth hormone, growth hormone receptor, ghrelin, insulin-like growth factor 1 and leptin in Mehraban sheep2013

    • Author(s)
      Bahrami A, Behzadi Sh, Miraei- Ashtiani S.R., Roh SG, Katoh K
    • Journal Title

      Gene

      Volume: 527(1) Issue: 1 Pages: 397-404

    • DOI

      10.1016/j.gene.2013.05.066

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haplotype C of growth hormone (GH) gene in Japanese Black cattle: Structure of GH protein and a novel method for detection of the gene2013

    • Author(s)
      Bahrami A, Ardiyanti A, Tonosaki K, Suzuki K, Tanida N, Hirayama T, Roh SG, Nishio T, Katoh K.
    • Journal Title

      Animal Science Journal

      Volume: 84 Issue: 12 Pages: 802-804

    • DOI

      10.1111/asj.12132

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] GH多型による黒毛和種牛の脂肪細胞の生理的特徴2016

    • Author(s)
      鈴木 裕、谷田 奈々子、加藤 大地、村井 篤嗣、平山 琢二、加藤 和雄、盧 尚建
    • Organizer
      第120回大会 日本畜産学会
    • Place of Presentation
      日本獣医生命大学(東京都武蔵野市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Insulin as a suppressive factor of GH release in the ruminant2015

    • Author(s)
      Katoh K, Kobayashi R, Nishihara K, Suzuki Y, Suzuki K, Roh SG.
    • Organizer
      66th EAAP ANNUAL MEETING
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RNA-Seqによる黒毛和種牛ルーメン発達関連遺伝子の網羅的トランスクリプトーム解析2015

    • Author(s)
      加藤 大地、鈴木 裕、芳賀 聡、蘇 敬夏、中野 美和、石崎 宏、河野 友宏、加藤 和雄、盧 尚建
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシ培養肝細胞におけるケメリン調節因子に関する研究2015

    • Author(s)
      近藤 光彦、鈴木裕、芳賀 聡、畑中 陽弦、加藤大地、蘇 敬夏、加藤和雄、盧 尚建
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウシ乳腺上皮細胞におけるケメリンの糖・脂質代謝関連遺伝子発現の調節作用2015

    • Author(s)
      加藤 大幾、鈴木 裕、芳賀 聡、蘇 敬夏、Hong-Gu Lee、U-Suk Jung、加藤 和雄、盧 尚建
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 反芻動物の採食に伴う成長ホルモン分泌抑制に関する研究2015

    • Author(s)
      小林 涼子、西原 昂来、盧 尚建、加藤 和雄
    • Organizer
      日本畜産学会 第119回大会
    • Place of Presentation
      宇都宮大学、宇都宮市
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Digital Differential Displayによるウシルーメン発達関連遺伝子のIn silico同定2014

    • Author(s)
      加藤 大地、鈴木 裕、芳賀 聡、蘇 敬夏、中野 美和、石崎 宏、 加藤 和雄、盧 尚建
    • Organizer
      第20回Hindgut Club Japanシンポジウム
    • Place of Presentation
      専修大学、東京都
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 絶食・再給餌によるマウス肝臓および脂肪組織におけるケメリンの発現調節2014

    • Author(s)
      鈴木 裕、蘇 敬夏、畑 優紀、熊谷 優希、加藤 和雄、盧 尚建
    • Organizer
      第48回日本栄養・食糧学会東北支部大会および公開シンポジウム
    • Place of Presentation
      東北大学、仙台市
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gene Expression and Regulation of Betatrophin in Cultured Hepatocytes of Preweaning and Postweaning Calves2014

    • Author(s)
      Roh SG, Yamauchi E, Suzuki Y, Kitayama S, Kondo M, Nakano M, Ishizaki H, Haga S, K. Katoh
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chemerin mRNA expression is regulated by insulin and fatty acids in the liver of calves2014

    • Author(s)
      Suzuki Y, Kitayama S, Kondo M, Haga S, Katoh K, Roh SG
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tissues Distribution and Expression Changes of the -tocopherol Related Genes Due to Short Term High Dose Oral Administration of -tocopherol in Weaned Beef Calves2014

    • Author(s)
      Haga S, Nakano M, Ishizaki H, Roh SG, Katoh K
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Postprandial reduction in plasma GH concentration is caused by insulin in goats2014

    • Author(s)
      Kobayashi R, Harjanti DW, Sano H, Roh SG, Katoh K
    • Organizer
      Joint ISNH/ISRP International Conference 2014
    • Place of Presentation
      Canberra, Australia
    • Year and Date
      2014-09-08 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 黒毛和種牛の内分泌変化と糖代謝に及ぼすGH多型の影響2013

    • Author(s)
      小林諒子、Harajanti D.W.、盧尚建、佐野 宏明、加藤和雄
    • Organizer
      日本畜産学会第177大会
    • Place of Presentation
      新潟大学
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-21   Modified: 2019-07-29  

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