| Project/Area Number |
25292164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Kyushu University |
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Principal Investigator |
TATSUMI RYUICHI 九州大学, (連合)農学研究科(研究院), 准教授 (40250493)
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| Co-Investigator(Kenkyū-buntansha) |
水野谷 航 九州大学, (連合)農学研究科(研究院), 助教 (20404056)
古瀬 充宏 九州大学, (連合)農学研究科(研究院), 教授 (30209176)
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| Research Collaborator |
ANDERSON JUDY E. マニトバ大学, 理学部, 教授
ALLEN RONALD E. アリゾナ大学, 教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | 食肉生産システム / 骨格筋 / 筋幹細胞 / 筋線維型 / 遅筋型筋線維 / 多機能性細胞制御因子Sema3A / 細胞膜受容体アゴニスト / ポリフェノール / 筋幹細胞(衛星細胞) / 骨格筋(食肉） / 遅筋型ミオシン / Sema3A / 細胞膜受容体 / 食品由来アゴニスト / 食肉生産 / 食品機能性 / 細胞外リガンド / 受容体アゴニスト / 筋管 |
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| Outline of Final Research Achievements |
Muscle fiber type proportions are responsible for contractile, metabolic, and sensory properties of skeletal muscles; therefore the regulatory mechanisms and their manipulation are hot targets of research for meat-animal production and human sports and health sciences. Recently, we found that resident myogenic stem satellite cells up-regulate a multi-functional secretome Sema3A exclusively at the myogenic-differentiation phase in response to muscle injury; however, its physiological significance is still unknown. The current study encouraged a possible mechanism to impact the formation of slow-twitch fibers through a novel signaling pathway, Sema3A ligand→cell-membrane receptor (neuropilin2-plexinA3)→myogenin/MEF2D→slow myosin. Notably, a subsequent study showed that supplementation of apple polyphenols or the major component chlorogenic acid up-regulated the expression of slow myosin, myogenin, and MEF2D, indicating that chlorogenic acid may function as a Sema3A-receptor agonist.
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