Understanding a novel mechanism to regulate myofiber types during muscle growth and regeneration
| Project/Area Number |
25292164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Kyushu University |
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Principal Investigator |
TATSUMI RYUICHI 九州大学, (連合)農学研究科(研究院), 准教授 (40250493)
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| Co-Investigator(Kenkyū-buntansha) |
水野谷 航 九州大学, (連合)農学研究科(研究院), 助教 (20404056)
古瀬 充宏 九州大学, (連合)農学研究科(研究院), 教授 (30209176)
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| Research Collaborator |
ANDERSON JUDY E. マニトバ大学, 理学部, 教授
ALLEN RONALD E. アリゾナ大学, 教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | 食肉生産システム / 骨格筋 / 筋幹細胞 / 筋線維型 / 遅筋型筋線維 / 多機能性細胞制御因子Sema3A / 細胞膜受容体アゴニスト / ポリフェノール / 筋幹細胞(衛星細胞) / 骨格筋(食肉） / 遅筋型ミオシン / Sema3A / 細胞膜受容体 / 食品由来アゴニスト / 食肉生産 / 食品機能性 / 細胞外リガンド / 受容体アゴニスト / 筋管 |
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| Outline of Final Research Achievements |
Muscle fiber type proportions are responsible for contractile, metabolic, and sensory properties of skeletal muscles; therefore the regulatory mechanisms and their manipulation are hot targets of research for meat-animal production and human sports and health sciences. Recently, we found that resident myogenic stem satellite cells up-regulate a multi-functional secretome Sema3A exclusively at the myogenic-differentiation phase in response to muscle injury; however, its physiological significance is still unknown. The current study encouraged a possible mechanism to impact the formation of slow-twitch fibers through a novel signaling pathway, Sema3A ligand→cell-membrane receptor (neuropilin2-plexinA3)→myogenin/MEF2D→slow myosin. Notably, a subsequent study showed that supplementation of apple polyphenols or the major component chlorogenic acid up-regulated the expression of slow myosin, myogenin, and MEF2D, indicating that chlorogenic acid may function as a Sema3A-receptor agonist.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Improvement of Endurance Based on Muscle Fiber-Type Composition by Treatment with Dietary Apple Polyphenols in Rats.2015
Author(s)
Mizunoya W, Miyahara H, Okamoto S, Akahoshi M, Suzuki T, Do MK, Ohtsubo H, Komiya Y, Lan M, Waga T, Iwata A, Nakazato K, Ikeuchi Y, Anderson JE, Tatsumi R
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Journal Title
PLoS One.
Volume: 10
Issue: 7
Pages: e0134303-e0134303
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Transmembrane proteoglycans syndecan-2, 4, receptor candidates for the impact of HGF and FGF2 on semaphorin 3A expression in early-differentiated myoblasts2015
Author(s)
Mai-Khoi Q. Do, Naomi Shimizu, Takahiro Suzuki, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Shoko Sawano, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi
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Journal Title
Physiological Reports
Volume: 3
Issue: 9
Pages: e12553-e12553
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: Promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle.2014
Author(s)
Sakaguchi S, Shono J, Suzuki T, Shoko S, Anderson JE, Do MKQ, Ohtsubo H, Mizunoya W, Sato Y, Nakamura M, Furuse M, Yamada K, Ikeuchi Y, Tatsumi R.
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Journal Title
International Journal of Biochemistry and Cell Biology
Volume: 52
Pages: 272-285
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.2014
Author(s)
Sakaguchi, S.,* Shono, J.,* Suzuki, T.,* Sawano, S., Anderson, J.E., Do, M.-K.Q., Ohtsubo, H., Mizunoya, W., Nakamura, M., Furuse, M., Ikeuchi, Y., and Tatsumi, R. (*equal contributors)
Organizer
Animal Science Congress 2014 of the Asian-Australian Association of Animal Production Societies (AAAP)
Place of Presentation
Universitas Gadjah Mada, Indonesia
Year and Date
2014-11-10 – 2014-11-14
Related Report
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[Presentation] Functional interaction between Sema3A and Pax7 in proliferation and differentiation of myoblasts.2014
Author(s)
Mulan, Nakamura, M., Suzuki, T., Mizunoya, W., Ojima, K., Tatsumi, R. and Ikeuchi, Y.
Organizer
International Symposium on Agriculture, Forestry, Environment and Life Sciences in Asia, 2014 (AFELiSA'14)
Place of Presentation
Ladena Condominium, Korea
Year and Date
2014-10-28 – 2014-10-31
Related Report
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[Presentation] M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.2014
Author(s)
Tatsumi, R.,* Sakaguchi, S.,* Shono, J.,* Suzuki, T.,* Sawano, S., Anderson, J.E., Do, M.-K.Q., Ohtsubo, H., Mizunoya, W., Nakamura, M., Furuse, M., and Ikeuchi, Y. (*equal contributors)
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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[Presentation] APOBEC2 deficiency up-regulates myoblast differentiation.2014
Author(s)
Ohtsubo, H., Sato, Y., Suzuki, T., Mizunoya, W., Nakamura, M., Tatsumi, R., and Ikeuchi, Y.
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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[Presentation] Sema3A secreted from satellite cells promotes slow-twitch fiber generation.2014
Author(s)
Suzuki, T., Ohya, Y., Ojima, K., Mizunoya, W., Sawano, S., Ohtsubo, H., Nishimatsu, S., Anderson, J. E., Do, M.-K. Q., Nakamura, M., Furuse, M., Ikeuchi, Y., Nohno, T., and Tatsumi, R.
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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[Presentation] Semaphorin 3A secreted from myogenic stem cells promotes slow-twitch muscle fiber generation2013
Author(s)
Suzuki, T., Ojima, K., Do, M.K.Q., Hara, M., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Anderson, J.E. and Tatsumi, R.
Organizer
2013 EMBO Workshop on “Semaphorin Function and Mechanism in Action”
Place of Presentation
Cemay-la-Ville, France
Related Report
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