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New function of interleukin-19 in type-IV contact hypersensitivity

Research Project

Project/Area Number 25292174
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionOsaka Prefecture University

Principal Investigator

Azuma Yasu-Taka  大阪府立大学, 生命環境科学研究科, 准教授 (50298816)

Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords皮膚炎 / Th17応答 / IL-19 / T細胞 / 炎症 / CHS / アレルギー / サイトカイン / DTH
Outline of Final Research Achievements

IL-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. Contact hypersensitivity (CHS) is T cell-mediated cutaneous inflammation. Therefore, we asked whether IL-19 causes CHS. We investigated the immunological role of IL-19 in CHS induced by 1-fluoro-2,4-dinitrofluorobenzene as a hapten. IL-19 was highly expressed in skin exposed to the hapten, and ear swelling was increased in IL-19 knockout mice. The exacerbation of the CHS response in IL-19 knockout mice correlated with increased levels of IL-17 and IL-6, but no alterations were noted in the production of IFNgamma and IL-4 in the T cells of the lymph nodes. In addition to the effect on T cell response, IL-19 knockout mice increased production of inflammatory cytokines. These results show that IL-19 suppressed hapten-dependent skin inflammation in the CHS.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (5 results)

All 2018 2017 2015 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] The Role of Interleukin-19 in Contact Hypersensitivity2018

    • Author(s)
      Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 2 Pages: 182-189

    • DOI

      10.1248/bpb.b17-00594

    • NAID

      130006329250

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Interleukin-19 contributes to T cell-mediated contact hypersensitivity2018

    • Author(s)
      Yasuyuki Fujimoto, Hidemitsu Nakajima, Tadayoshi Takeuchi, and Yasu-Taka Azuma
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アレルギー性皮膚炎におけるIL-19を介した新規調節機構の解明.2017

    • Author(s)
      藤本泰之、東 泰孝、中嶋秀満、竹内正吉
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 接触型過敏症におけるIL-19の機能的役割.2015

    • Author(s)
      藤本泰之,東 泰孝,中嶋秀満,竹内正吉
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学(十和田市、青森県)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of IL-19 in T cell-mediated immune responses.2014

    • Author(s)
      東 泰孝、松尾有希子、中嶋秀満、竹内正吉
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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