| Project/Area Number |
25292181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kagoshima University |
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Principal Investigator |
Yamato Osamu 鹿児島大学, 農水産獣医学域獣医学系, 教授 (80261337)
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| Co-Investigator(Kenkyū-buntansha) |
矢吹 映 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Takashi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (00184656)
UCHIDA Kazuyuki 東京大学, 大学院農学生命科学研究科, 准教授 (10223554)
MATSUKI Naoaki 東京大学, 大学院農学生命科学研究科, 教授 (40251417)
NAKAICHI Munekazu 山口大学, 共同獣医学部, 教授 (60243630)
HASEGAWA Daisuke 日本獣医生命科学大学, 獣医学部, 准教授 (20366793)
SAITO Miyoko 麻布大学, 獣医学部, 准教授 (80367242)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 動物遺伝子病 / 分子基盤 / 遺伝子型検査 / 分子疫学 / 疾患モデル動物 |
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| Outline of Final Research Achievements |
In a number of genetic diseases in companion animals identified in the previous and present studies, the molecular bases were identified, and the genotyping tests were developed. In part of the diseases, the molecular epidemiological surveys were performed, and the preventive methods were established according to the importance of each disease, which had been estimated on the data of the surveys. The preventive measure was successfully achieved by decreasing the mutant allele frequency in canine neuronal ceroid lipofuscinosis. Anti-inflammatory therapy using a steroid was carried out in canine trapped neutrophil syndrome and feline GM2 gangliosidosis. It was suggested that the therapy for canine trapped neutrophil syndrome is effective to prolong the survival period of the affected animals. In addition, during the period of this research, a lot of novel genetic diseases were found, and the research about these diseases can be continued to the next related research project.
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