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Development of therapeutic agents and vaccines against feline infectious peritonitis

Research Project

Project/Area Number 25292183
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionKitasato University

Principal Investigator

Hohdatsu Tsutomu  北里大学, 獣医学部, 教授 (00129264)

Co-Investigator(Kenkyū-buntansha) Takano Tomomi  北里大学, 獣医学部, 准教授 (20525018)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords猫伝染性腹膜炎 / ワクチン / 抗ウイルス薬 / TNF-α / コロナウイルス / 分子標的薬 / 抗サイトカイン療法 / 抗TNF製剤
Outline of Final Research Achievements

Feline infectious peritonitis (FIP) is a virus-induced fatal disease in cats. There have been no reports on agents that have exhibited therapeutic or preventive effects. On the basis of these facts, we have tried to develop therapeutic agents and vaccines against FIP. We selected peptides that strongly induced Th1 activity from the peptides derived from FIPV structural proteins. Prevention against FIPV-induced FIP was slightly better in SPF cats treated with peptides derived from the structural protein of FIPV. We have prepared monoclonal antibodies (MAb) that neutralize feline TNF-α(MAb 2-4).Progression to FIP was prevented in 2 out of 3 cats treated with MAb 2-4. These results may provide important information for the development of therapeutic agents and vaccines against FIP.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (14 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (4 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Differential effect of cholesterol on type I and II feline coronavirus infection2016

    • Author(s)
      Takano T, Satomi Y, Oyama Y, Doki T, Hohdatsu T.
    • Journal Title

      Arch Virol

      Volume: 161 Issue: 1 Pages: 125-133

    • DOI

      10.1007/s00705-015-2655-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis.2016

    • Author(s)
      Doki T, Takano T, Kawagoe K, Kito A, Hohdatsu T.
    • Journal Title

      Res Vet Sci

      Volume: 104 Pages: 17-23

    • DOI

      10.1016/j.rvsc.2015.11.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Detection of canine astrovirus in dogs with diarrhea in Japan.2015

    • Author(s)
      Takano T, Takashina M, Doki T, Hohdatsu T.
    • Journal Title

      Archives of Virology

      Volume: in press Pages: 13-20

    • DOI

      10.1016/j.virusres.2015.04.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II2015

    • Author(s)
      Takano T, Nakano K, Doki T, Hohdatsu T.
    • Journal Title

      Arch Virol.

      Volume: 160(5) Pages: 1163-1170

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in spike 1 domain and membrane protein of feline infectious peritonitis virus.2014

    • Author(s)
      Takano T., Morioka, H., Gomi, K., Tomizawa, K., Doki, T. and Hohdatsu, T.
    • Journal Title

      Vaccine

      Volume: 32 Issue: 16 Pages: 1834-1840

    • DOI

      10.1016/j.vaccine.2014.01.074

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of protective efficacy of the synthetic peptide vaccine containing the T helper 1 epitope with CpG oligodeoxynucleotide against feline infectious peritonitis virus infection in cats.2014

    • Author(s)
      Takano, T., Tomizawa, K., Morioka, H., Doki, T. and Hohdatsu, T.
    • Journal Title

      Antivir Ther

      Volume: in press Issue: 7 Pages: 645-650

    • DOI

      10.3851/imp2735

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation, characterization and therapeutic potential of anti-feline TNF-alpha MAbs for feline infectious peritonitis.2013

    • Author(s)
      Doki, T., Takano, T., Nishiyama, Y., Nakamura, M. and Hohdatsu, T.
    • Journal Title

      Res Vet Sci

      Volume: 95 Issue: 3 Pages: 1248-1254

    • DOI

      10.1016/j.rvsc.2013.09.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of recombinant nucleocapsid proteins for serological diagnosis of feline coronavirus infection by three immunochromatographic tests.2013

    • Author(s)
      Takano, T., Ishihara, Y., Matsuoka, M., Yokota, S., Matsuoka-Kobayashi, Y., Doki, T. and Hohdatsu, T.
    • Journal Title

      J Virol Methods

      Volume: 196 Pages: 1-6

    • DOI

      10.1016/j.jviromet.2013.10.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ネコTNF-αを中和するマウスモノクローナル抗体のネコ伝染性腹膜炎(FIP)に対する治療効果とマウス・ネコキメラ化抗体の作製2015

    • Author(s)
      土岐朋義、川越浩平、高野友美、宝達勉
    • Organizer
      第11回日本獣医内科学アカデミー学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2015-02-20 – 2015-02-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] I型feline infectious peritonitis virus (FIPV) S蛋白質(S1ドメイン)由来peptideのcoronavirusに対する感染抑制効果2014

    • Author(s)
      土岐朋義、高野友美、小山祐介、宝達勉
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] I型猫伝染性腹膜炎ウイルス(FIPV)KU-2株N蛋白質由来peptide(NP)のFIP発症予防効果の検討2013

    • Author(s)
      土岐朋義、高野友美、冨沢圭佑、盛岡寛行、佐藤亮一、宝達勉
    • Organizer
      日本獣医学会
    • Place of Presentation
      岐阜大学(岐阜県岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 猫伝染性腹膜炎ウイルスの構造蛋白質(MおよびS1 domain)におけるTh1 epitopeの検索とTh1活性誘導能について2013

    • Author(s)
      高野友美、盛岡寛行、冨沢圭佑、五味宏二、土岐朋義、宝達勉
    • Organizer
      日本獣医学会
    • Place of Presentation
      岐阜大学(岐阜県岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Book] Coronaviruses2015

    • Author(s)
      Takano T, Hohdatsu T.
    • Total Pages
      283
    • Publisher
      Humana Press
    • Related Report
      2014 Annual Research Report
  • [Remarks] 猫伝染性腹膜炎(FIP)に対するクロロキンの治療効果

    • URL

      https://www.kitasato-u.ac.jp/vmas/faculty/vm/topix_index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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