| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Outline of Final Research Achievements |
In some pathologies such as sarcopenia and muscular dystrophy, fat accumulation (appearance of adipocytes) is seen in skeletal muscle. The accumulated adipocytes are considered to affect skeletal muscle function. The present study was undertaken to elucidate the mechanism of fat accumulation and its pathophysiological significance. We have identified chondroitin sulfate proteoglycan 4 (CSPG4) as a molecule involved in adipogenic and fibrogenic differentiation of mesenchymal progenitor cells. In addition, we have succeeded in generating lines of novel muscular dystrophy model rats by genome editing.
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