Elucidating the mechanism of fat accumulation in skeletal muscle and its pathophysiological significance.
| Project/Area Number |
25292185
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 骨格筋 / 脂肪細胞 / 線維芽細胞 / 間葉系前駆細胞 / CSPG4 / ジストロフィン / 筋分化 / 脂肪分化 / 筋ジストロフィー / サルコペニア / 再生医学 / 筋細胞 / 細胞・組織 / 生理学 / 畜産学 / 発生・分化 |
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| Outline of Final Research Achievements |
In some pathologies such as sarcopenia and muscular dystrophy, fat accumulation (appearance of adipocytes) is seen in skeletal muscle. The accumulated adipocytes are considered to affect skeletal muscle function. The present study was undertaken to elucidate the mechanism of fat accumulation and its pathophysiological significance. We have identified chondroitin sulfate proteoglycan 4 (CSPG4) as a molecule involved in adipogenic and fibrogenic differentiation of mesenchymal progenitor cells. In addition, we have succeeded in generating lines of novel muscular dystrophy model rats by genome editing.
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Report
(5 results)
Research Products
(40 results)
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[Journal Article] Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.2016
Author(s)
Takeuchi S, Nakano S, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi S, Yamanouchi K, Nishihara M
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Journal Title
Experimental Cell Research
Volume: 347
Issue: 2
Pages: 367-377
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M2014
Author(s)
Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M
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Journal Title
Scientific Reports
Volume: 4
Issue: 1
Pages: 5635-5635
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Identification of chondroitin sulfate proteoglycan 4 as a marker for mesenchymal progenitor cells and its possible involvement in adipogenic/fibrogenic differentiation.2016
Author(s)
Takeuchi S, Nakano SI, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi SI, Yamanouchi K, Nishihara M
Organizer
FASEB summer research conference "Skeletal Muscle Satellite Cells and Regeneration"
Place of Presentation
Keystone, CO, USA
Year and Date
2016-07-26
Related Report
Int'l Joint Research
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[Presentation] Generation of dystrophin mutated rats with a CRISPR/Cas system as a new animal model of muscular dystrophy.2014
Author(s)
Nakamura K, Fujii W, Tsuboi M, Yanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M
Organizer
FASEB summer research conference "Skeletal Muscle Satellite and Stem Cells"
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-22
Related Report
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