Molecular basis of maternal behavior~using Usp46 mutant mice~

• Project/Area Number: 25292186
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Kwansei Gakuin University (2016); Nagoya University (2013-2015)
• Principal Investigator: Ebihara Shizufumi 関西学院大学, 理工学部, 教授 (50135331)
• Co-Investigator(Kenkyū-buntansha): 高田 耕司 東京慈恵会医科大学, 医学部, 教授 (30179452)
• Co-Investigator(Renkei-kenkyūsha): KATO Takashi 早稲田大学, 教育・総合科学学術院, 教授 (80350388)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: マウス / 養育行動 / 脱ユビキチン化酵素 / 概日リズム / 行動 / 児童虐待 / モデル動物

Outline of Final Research Achievements

Biological investigation (such as using animal models) of generating mechanisms of child abuse has not been well performed although this has been treated in a field of social science (psychology and education) and clinical science (psychiatry). In this study, therefore, we examined the role of Usp46 on cellular and nervous system using Usp46 mutant mice which display poor maternal behavior. As a result, we found that the level of maternal care is transmitted to their pups and proper maternal behaviors can be shaped if adequate postpartum maternal care is given, even in genetically vulnerable mice. In addition, it is suggested that Usp46 affects several behavioral phenotypes through GABAergic system.

Research Products

• [Journal Article] Impaired maternal behavior in Usp46 mutant mice: a model for trans-generational transmission of maternal care. (2015)
  • Author(s): Umemura S, Imai S, Mimura A, Fujiwara M, Ebihara S.
  • Journal Title: PLoS One Volume: 10(8)
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice (2013)
  • Author(s): Imai S, Kano M, Nonoyama K, Ebihara S
  • Journal Title: PLoS One Volume: 8(3) Issue: 3 Pages: e58566-e58566
  • DOI: 10.1371/journal.pone.0058566
  • Peer Reviewed
• [Presentation] 時間生物学の進歩と展望 (2014)
  • Author(s): 海老原史樹文
  • Organizer: 日本時間生物学会
  • Place of Presentation: 九州大学百年講堂
  • Year and Date: 2014-11-08 – 2014-11-09
  • Invited
• [Presentation] Usp46突然変異が及ぼすマウス概日リズムへの影響 (2014)
  • Author(s): 房田郁子、繁田あずさ、今井早希、海老原史樹文
  • Organizer: 日本時間生物学会
  • Place of Presentation: 九州大学百年講堂
  • Year and Date: 2014-11-08 – 2014-11-09
  • Invited
• [Presentation] マウスにおけるUsp46変異がGABAA受容体サブユニットに及ぼす影響 (2013)
  • Author(s): 今井早希、海老原史樹文
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館