| Project/Area Number |
25292186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Kwansei Gakuin University (2016)
Nagoya University (2013-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高田 耕司 東京慈恵会医科大学, 医学部, 教授 (30179452)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Takashi 早稲田大学, 教育・総合科学学術院, 教授 (80350388)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | マウス / 養育行動 / 脱ユビキチン化酵素 / 概日リズム / 行動 / 児童虐待 / モデル動物 |
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| Outline of Final Research Achievements |
Biological investigation (such as using animal models) of generating mechanisms of child abuse has not been well performed although this has been treated in a field of social science (psychology and education) and clinical science (psychiatry). In this study, therefore, we examined the role of Usp46 on cellular and nervous system using Usp46 mutant mice which display poor maternal behavior. As a result, we found that the level of maternal care is transmitted to their pups and proper maternal behaviors can be shaped if adequate postpartum maternal care is given, even in genetically vulnerable mice. In addition, it is suggested that Usp46 affects several behavioral phenotypes through GABAergic system.
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