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Analysis of polymorphisms in regulatory regions of gene expression for pig custom breeding design

Research Project

Project/Area Number 25292190
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionNational Agriculture and Food Research Organization (2016)
National Institute of Agrobiological Sciences (2013-2015)

Principal Investigator

Uenishi Hirohide  国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門・動物機能利用研究領域, ユニット長 (80391556)

Co-Investigator(Kenkyū-buntansha) 中島 郁世  国立研究開発法人農業・食品産業技術総合研究機構, 畜産草地研究所, 主任研究員 (60355063)
小川 智子  国立研究開発法人農業生物資源研究所, 家畜ゲノム研究ユニット, 主任研究員 (90466011)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywordsゲノム / プロモータ / 多型 / ブタ / 次世代シーケンサー / 転写因子
Outline of Final Research Achievements

To determine the indices to improve fat-related traits in pigs, we clarified polymorphisms in promoter regions of the genes related to lipid synthesis and/or differentiation and proliferation of adipocytes by genome concentration and next-generation sequencing techniques. Furthermore, we extracted the polymorphisms affecting binding ability of transcription factors related to lipid synthesis or adipocytes. Some of the extracted polymorphisms were located within the genomic regions of quantitative trait loci of fat-related phenotypes, suggesting the availability of the polymorphisms for improvement of fat-related traits of pigs.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Polymorphisms in promoter regions of lipid/adipocyte-related genes in pigs and their distribution among different breeds2016

    • Author(s)
      Hirohide Uenishi, Toshimi Matsumoto, Tomoko Eguchi-Ogawa, Ikuyo Nakajima
    • Organizer
      International Plant and Animal Genome Conference XXIV
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-01-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2013-05-21   Modified: 2019-07-29  

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