| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
We have studied the molecular mechanisms of insect metamorphosis at a cellular level. (1) Pupal commitment of a single-celled Verson’s gland occurs gradually. (2) This commitment is caused by the decline of JH titer and nutrition, and it occurs by a two-step process by both the insulin signaling and TOR signaling pathway. (3) We found a gene responsible for the segment specific cell death of Verson’s glands, the gene of which is involved in the JH signaling pathway. (4) The cell death of a larval-specific organ, crochet, is caused by apoptosis, and the commitment of the death is initiated shortly before and/or after the final ecdysis.
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