Molecular mechanisms of pupal commitment and programed cell death during insect metamorphosis
Project/Area Number |
25292195
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Insect science
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Research Institution | Hirosaki University |
Principal Investigator |
Hiruma Kiyoshi 弘前大学, 農学生命科学部, 教授 (70374816)
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Co-Investigator(Kenkyū-buntansha) |
KANEKO YU 弘前大学, 農学生命科学部, 助教 (90633610)
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Co-Investigator(Renkei-kenkyūsha) |
BANNO YUTAKA 九州大学, 連合農学研究科, 准教授 (50192711)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
Keywords | Verson's gland / 蛹変態 / エクダイソン / コミットメント / 幼若ホルモン / インスリン / crochet / 細胞死 |
Outline of Final Research Achievements |
We have studied the molecular mechanisms of insect metamorphosis at a cellular level. (1) Pupal commitment of a single-celled Verson’s gland occurs gradually. (2) This commitment is caused by the decline of JH titer and nutrition, and it occurs by a two-step process by both the insulin signaling and TOR signaling pathway. (3) We found a gene responsible for the segment specific cell death of Verson’s glands, the gene of which is involved in the JH signaling pathway. (4) The cell death of a larval-specific organ, crochet, is caused by apoptosis, and the commitment of the death is initiated shortly before and/or after the final ecdysis.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Identification of two juvenile hormone inducible transcription factors from the silkworm, Bombyx mori2015
Author(s)
Hitoshi Matsumoto, Chihiro Ueno, Yuki Nakamura, Terunori Kinjoh, Yuka Ito, Sachiko Shimura, Hiroaki Noda, Shigeo Imanishi, Kazuei Mita, Fujiwara Haruhiko, Kiyoshi Hiruma, Tetsuro Shinoda, and Manabu Kamimura
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Journal Title
J. Insect Physiol
Volume: なし
Pages: 31-41
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Molecular cloning, developmental expression, and tissue distribution of diapause hormone and pheromone biosynthesis activating neuropeptide in the bamboo borer, Omphisa fuscidentalis2015
Author(s)
Suang, S., Manaboon, M., Chantawannakul, P., Singtripop, T., Hiruma, K., and Kaneko, Y.
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Journal Title
Physiol. Entomol.
Volume: 40
Issue: 3
Pages: 247-256
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Hormonal regulation and developmental role of Kruppel homolog 1, a repressor of metamorphosis, in the silkworm Bombyx mori2014
Author(s)
Kayukawa T, Murata M, Kobayashi I, Muramatsu D, Okada C, Uchino K, Sezutsu H, Kiuchi M, Tamura T, Hiruma K, Ishikawa Y, Shinoda T
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Journal Title
Developmental Biology
Volume: 388
Issue: 1
Pages: 48-56
DOI
Related Report
Peer Reviewed
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[Presentation] Juvenile hormone enhances oxidative stress resistance through the induction of anti-oxidant gene expression in the silkworm, Bombyx mori2014
Author(s)
Kamimura, M., Ueno, C., Matsumoto, H., Shimura, S., Nakamura, Y., Noda, H., Imanishi, S., Mita, K., Hiruma, K., and Shinoda, T.
Organizer
10th International Congress on Juvenile Hormone
Place of Presentation
Tsukuba, Japan
Year and Date
2014-06-09 – 2014-06-13
Related Report
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[Presentation] The role of molt timers in determining instar length in Manduca sexta2013
Author(s)
Truman, J.W., Suzuki, Y., Koyama, T., Hiruma, K., and Riddiford, L.M.
Organizer
International Insect Hormone (19th Ecdysone) Workshop
Place of Presentation
University of Minnesota, USA
Related Report
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