Study on the molecular mechanisms of baculovirus tissue tropism
| Project/Area Number |
25292196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Insect science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATSUMA Susumu 東京大学, 農学生命科学研究科, 准教授 (20378863)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | バキュロウイルス / 組織トロピズム / 行動制御 / カイコ / 昆虫病理学 / BmNPV / 変異体 / 経口感染 / 非コードRNA / トランスクリプトーム / チョウ目昆虫 / 変異ウイルス / 次世代シークエンサー |
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| Outline of Final Research Achievements |
The Baculoviridae is a large family of pathogens that are infectious for arthropods, particularly insects of the Lepidoptera. Baculoviruses are known to potentially encode >100 proteins, some of which are utilized to control host physiology at cellular and/or organismal levels. Lepidopteran baculoviruses show distinct tissue tropism in host insect larvae, but the molecular mechanisms of this tropism and its relationship to viral control of host caterpillars are largely unknown. In this study, I attempted to identify the genes involved in baculovirus tissue tropism and to clarify their roles in baculoviral host control.
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Report
(4 results)
Research Products
(24 results)
