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Study on the molecular mechanisms of baculovirus tissue tropism

Research Project

Project/Area Number 25292196
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Insect science
Research InstitutionThe University of Tokyo

Principal Investigator

KATSUMA Susumu  東京大学, 農学生命科学研究科, 准教授 (20378863)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywordsバキュロウイルス / 組織トロピズム / 行動制御 / カイコ / 昆虫病理学 / BmNPV / 変異体 / 経口感染 / 非コードRNA / トランスクリプトーム / チョウ目昆虫 / 変異ウイルス / 次世代シークエンサー
Outline of Final Research Achievements

The Baculoviridae is a large family of pathogens that are infectious for arthropods, particularly insects of the Lepidoptera. Baculoviruses are known to potentially encode >100 proteins, some of which are utilized to control host physiology at cellular and/or organismal levels. Lepidopteran baculoviruses show distinct tissue tropism in host insect larvae, but the molecular mechanisms of this tropism and its relationship to viral control of host caterpillars are largely unknown. In this study, I attempted to identify the genes involved in baculovirus tissue tropism and to clarify their roles in baculoviral host control.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (24 results)

All 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 5 results,  Open Access: 1 results) Presentation (11 results) Book (2 results) Remarks (3 results)

  • [Int'l Joint Research] NIH/ユタ大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Phosphatase activity of Bombyx mori nucleopolyhedrovirus PTP is dispensable for enhanced locomotory activity in B. mori larvae2015

    • Author(s)
      Katsuma S
    • Journal Title

      Journal of Invertebrate Pathology

      Volume: 132 Pages: 228-232

    • DOI

      10.1016/j.jip.2015.11.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bombyx mori nucleopolyhedrovirus ARIF-1 enhances systemic infection in B. mori larvae2015

    • Author(s)
      Ryuhei Kokusho, Munetaka Kawamoto, Yasue Koyano, Sumio Sugano, Yutaka Suzuki, Toru Shimada, and Susumu Katsuma
    • Journal Title

      Journal of General Virology

      Volume: 印刷中 Issue: 7 Pages: 1938-1946

    • DOI

      10.1099/vir.0.000130

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe2015

    • Author(s)
      Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 112 Issue: 32

    • DOI

      10.1073/pnas.1505481112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The killing speed of egt-inactivated Bombyx mori nucleopolyhedrovirus depends on the developmental stage of B. mori larvae2015

    • Author(s)
      Susumu Katsuma and Toru Shimada
    • Journal Title

      Journal of Invertebrate Pathology

      Volume: 126 Pages: 64-70

    • DOI

      10.1016/j.jip.2015.01.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Deletion analysis of a superoxide dismutase gene of Bombyx mori (Lepidoptera: Bombycidae) nucleopolyhedrovirus2015

    • Author(s)
      Susumu Katsuma, Hisanori Bando, and Toru Shimada
    • Journal Title

      Applied Entomology and Zoology

      Volume: 50 Issue: 1 Pages: 57-62

    • DOI

      10.1007/s13355-014-0304-9

    • NAID

      40020374331

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The BIR and BIR-like domains of Bombyx mori nucleopolyhedrovirus IAP2 protein are required for efficient viral propagation2014

    • Author(s)
      Hanako Ito, Hisanori Bando, Toru Shimada, and Susumu Katsuma
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 454 Issue: 4 Pages: 581-587

    • DOI

      10.1016/j.bbrc.2014.10.132

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] BmNPVのgp64初期転写物は経口感染に必須である2015

    • Author(s)
      勝間進・川本宗孝・石原玄基・菅野純夫・鈴木穣・嶋田透
    • Organizer
      第75回昆虫病理研究会
    • Place of Presentation
      北海道大学農学部(北海道・札幌市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] BmNPVのBM5タンパク質は子孫ウイルスの産生と感染後期のウイルス遺伝子発現制御に関与する2015

    • Author(s)
      國生龍平・黄嘉禾・堤伸浩・嶋田透・勝間進
    • Organizer
      第75回昆虫病理研究会
    • Place of Presentation
      北海道大学農学部(北海道・札幌市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] RNA-seqを用いたBmNPVにおける経口感染プロセスの解明2014

    • Author(s)
      勝間進・川本宗孝・菅野純夫・鈴木穣・嶋田透
    • Organizer
      第11回昆虫病理研究会シンポジウム
    • Place of Presentation
      富士Calm
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] バキュロウイルスの経口感染に必須なアンチセンスRNAの解析2014

    • Author(s)
      石原玄基・嶋田透・勝間進
    • Organizer
      第11回昆虫病理研究会シンポジウム
    • Place of Presentation
      富士Calm
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] BmNPVの徘徊行動関連遺伝子arif-1の機能解析2014

    • Author(s)
      國生龍平・川本宗孝・嶋田透・勝間進
    • Organizer
      第11回昆虫病理研究会シンポジウム
    • Place of Presentation
      富士Calm
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] バキュロウイルス由来長鎖非コードRNAの機能解析

    • Author(s)
      石原玄基・嶋田透・勝間進
    • Organizer
      第74回昆虫病理研究会
    • Place of Presentation
      東京大学農学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] arif-1:新たな徘徊行動関連遺伝子

    • Author(s)
      國生龍平・嶋田透・勝間進
    • Organizer
      第74回昆虫病理研究会
    • Place of Presentation
      東京大学農学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] vp39変異体の機能解析

    • Author(s)
      勝間進・嶋田透
    • Organizer
      第74回昆虫病理研究会
    • Place of Presentation
      東京大学農学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] カイコ核多角体病ウイルスIAP2の機能解析

    • Author(s)
      伊藤華子・伴戸久徳・嶋田透・勝間進
    • Organizer
      第74回昆虫病理研究会
    • Place of Presentation
      東京大学農学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] BmNPVにおける新たな徘徊行動関連遺伝子arif-1の発見と機能解析

    • Author(s)
      國生龍平・川本宗孝・嶋田透・勝間進
    • Organizer
      日本蚕糸学会第84回大会
    • Place of Presentation
      日本大学生物資源科学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] バキュロウイルスにおける機能性長鎖非コードRNAの解析

    • Author(s)
      石原玄基・嶋田透・勝間進
    • Organizer
      日本蚕糸学会第84回大会
    • Place of Presentation
      日本大学生物資源科学部
    • Related Report
      2013 Annual Research Report
  • [Book] 昆虫科学読本2015

    • Author(s)
      日本昆虫科学連合
    • Total Pages
      286
    • Publisher
      東海大学出版
    • Related Report
      2014 Annual Research Report
  • [Book] 最新昆虫病理学2014

    • Author(s)
      国見裕久・小林迪弘 編著
    • Total Pages
      261
    • Publisher
      講談社
    • Related Report
      2013 Annual Research Report
  • [Remarks] バキュロウイルスによる翻訳制御メカニズムの解明

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2015/20150728-1.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学昆虫遺伝研究室

    • URL

      http://papilio.ab.a.u-tokyo.ac.jp/igb/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学 昆虫遺伝研究室ホームページ

    • URL

      http://papilio.ab.a.u-tokyo.ac.jp/igb/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2022-01-27  

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