| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Outline of Final Research Achievements |
Four-membered carbocyclic ring systems, including cyclobutanes and cyclobutenes, are one of fundamental and important structural units. Four-membered ring compounds are frequently found in natural and unnatural products displaying unique biological activities. In addition, cyclobutanes and cyclubutenes have been utilized as key intermediates in synthetic routes producing structurally complex targets because of their unique chemical transformation such as ring-opening and ring-expansion reactions. Despite their high utility, only a limited number of practical and efficient methods exist for their synthesis. We found several new chemistry of cyclobutanes, cyclobutenes and related substances. We also demonstrated its synthetic application to biologically active substances having 4-membered carbocyles.
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