| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Human living activity is maintained by systemic and pulmonary blood circulation, and muscular cells, including cardiomyocytes, vascular smooth muscle cells, and skeltal muscle cells, predominantly support this system. We focused on transient receptor potential canonical 3 and 6 heterotetramer channels (TRPC3/6), a non-selective cation-permeable channel that regualtes resting membrane potential in cells, and found that inhibition of TRPC3/6 channel activities in muscular cells will be a new strategy for the prevention of our cardiovascular system from ischemic and hypertensive stresses, using mouse models for human cardiovascular diseases.
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