Study on the regulation of cardiac homeostasis by formation of TRPC3/6 channel protein complex
Project/Area Number |
25293018
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
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Research Institution | Okazaki Research Facilities, National Institutes of Natural Sciences |
Principal Investigator |
Nishida Motohiro 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90342641)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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Keywords | 心血管疾患 / チャネル / 恒常性 / 活性酸素 / 創薬 / レジリエンス / 心血管リモデリング / TRPチャネル / 血管成熟 / 線維化 / 心血管 / カルシウムチャネル / TRPC / 再生・修復 / 心血管病 / カルシウム / イオンチャネル / 薬理学 / 生理学 |
Outline of Final Research Achievements |
Human living activity is maintained by systemic and pulmonary blood circulation, and muscular cells, including cardiomyocytes, vascular smooth muscle cells, and skeltal muscle cells, predominantly support this system. We focused on transient receptor potential canonical 3 and 6 heterotetramer channels (TRPC3/6), a non-selective cation-permeable channel that regualtes resting membrane potential in cells, and found that inhibition of TRPC3/6 channel activities in muscular cells will be a new strategy for the prevention of our cardiovascular system from ischemic and hypertensive stresses, using mouse models for human cardiovascular diseases.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension2016
Author(s)
A. Nishimura, C. Sunggip, H. Tozaki-Saitoh, T. Shimauchi, T. Numaga-Tomita, K. Hirano, T. Ide, J-M. Boeynaems, H. Kurose, M. Tsuda, B. Robaye, K. Inoue and M. Nishida
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Journal Title
Science Signaling
Volume: Jan 19;9(411)
Issue: 411
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds2016
Author(s)
S. Sawamura, M. Hatano, Y. Takada, K. Hino, T. Kawamura, J. Tanikawa, H. Nakagawa, H. Hase, A. Nakao, M. Hirano, R. Rotrattanadumrong, S. Kiyonaka, M.X. Mori, M. Nishida, Y. Hu, R. Inoue, R. Nagata and Y. Mori
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Journal Title
Mol Pharmacol
Volume: 89(3)
Issue: 3
Pages: 348-363
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.2015
Author(s)
Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
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Journal Title
Chem Res Toxicol.
Volume: 印刷中
Issue: 5
Pages: 838-847
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.2014
Author(s)
Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
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Journal Title
Cardiovas Res
Volume: 104
Pages: 183-193
NAID
Related Report
Peer Reviewed
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[Journal Article] GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance2013
Author(s)
Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Kuroda M, Inoue K, Kurose H
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Journal Title
Nature Commun
Volume: 4
Issue: 1
Pages: 1532-1532
DOI
Related Report
Peer Reviewed
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[Journal Article] Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.2013
Author(s)
Chen W, Oberwinkler H, Werner F, Gaßner B, Nakagawa H, Feil R, Hofmann F, Schlossmann J, Dietrich A, Gudermann T, Nishida M, Del Galdo S, Wieland T, Kuhn M.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 33
Issue: 9
Pages: 2121-2129
DOI
Related Report
Peer Reviewed
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