Search for natural molecules that control memory and pain from medicinal resources and drug development reserach
| Project/Area Number |
25293023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北島 満里子 千葉大学, 薬学研究科(研究院), 准教授 (60195261)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 天然活性物質 / 生物活性物質の探索 / 鎮痛剤 / 認知症改善薬 / 全合成 / アルカロイド / 構造活性相関 / 天然物化学 / 生物活性分子の合成 / 生物活性物質の合成 |
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| Outline of Final Research Achievements |
Search on drug development of new analgesics for cancer pain based on natural molecules were investigated. New indole alkaloid derivatives having potent opioid analgesic activity and good metabolic stability were developed. The total synthesis of C5-nor stemmadenine-type alkaloids with non-opioid analgesic activity was accomplished. Ibooga-type indole alkaloids having potent TRPM8 antagonistic activity were found. To search new acetylcholinesterase inhibitors for development of medicines improving the memory disorders, isolation and asymmetric total syntheses of new Lycopodium alkaloids were achieved.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.2014
Author(s)
Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
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Journal Title
J Pharmacol Exp Ther.
Volume: 348
Issue: 3
Pages: 383-392
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 4-Chlorocolchicine Derivatives Bearing a Thiourea Side Chain at the C-7 Position as Potent Anticancer Agents2014
Author(s)
H. Nishiyama, M. Ono, T. Sugimoto, T. Sasai, N. Asakawa, S. Ueno, Y. Tominaga, T. Yaegashi, M. Nagaoka, T. Matsuzaki, N. Kogure, M. Kitajima, and H. Takayama
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Journal Title
Med. Chem. Commun.
Volume: 5
Issue: 4
Pages: 452-458
DOI
Related Report
Peer Reviewed
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[Presentation] キョウチクトウ科植物Kopsia arborea含有新規インドールアルカロイドKopsiyunnanines E, I, J1, J22014
Author(s)
村上洋介, 小山徹也, 鈴木悠太, 高橋伸明, Yuqui Wu , 小暮紀行, Rongping Zhang, 北島満里子, 高山廣光
Organizer
第56回天然有機化合物討論会
Place of Presentation
高知
Year and Date
2014-10-15
Related Report
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[Presentation] 新規Colchicine誘導体の合成を抗腫瘍効果
Author(s)
西山裕之, 小野雅弘, 杉本卓弥, 笹井俊雄, 浅川直之, 上野哲, 富永恵隆, 八重樫隆, 長岡正人, 松崎健, 小暮紀行, 北島満里子, 高山廣光
Organizer
第31回メディシナルケミストリーシンポジウム
Place of Presentation
広島
Related Report
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