• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Discovery of antitumor drug candidates from rainforest plants

Research Project

Project/Area Number 25293024
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Natural medicines
Research InstitutionKanazawa University

Principal Investigator

Goto Kyoko  金沢大学, 薬学系, 准教授 (50180245)

Co-Investigator(Kenkyū-buntansha) 三宅 克典  東京薬科大学, 薬学部, 助教 (20597687)
Research Collaborator GOTO Masuo  Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Research Professor
Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords熱帯雨林産植物 / 熱帯林産植物 / 抗がん剤リード / 熱帯林植物 / 抗がん剤候補 / 生理活性天然物 / 発がん予防効果 / 熱帯林植物産天然物
Outline of Final Research Achievements

Over 60 of novel natural products were isolated from six rainforest plant extracts, which were provided by National Cancer Institute in USA. Among them, the potent antitumor compounds were selected and constructed their total synthetic routes. Further preparations of their derivatives and study of structure-activity relationship were carried out.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (48 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (16 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 16 results,  Acknowledgement Compliant: 9 results,  Open Access: 2 results) Presentation (22 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] ノースカロライナ大学/国立がん研究所(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] アカデミアシニカ(台湾)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(Taiwan)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] National Cancer Institute/University of North Carolina(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ノースカロライナ大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] アカデミアシニカ  中央研究院農業生物科技研究所(台湾)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Secondary Metabolites, Monoterpene?Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata2018

    • Author(s)
      Tsurumi Fumika、Miura Yuta、Saito Yohei、Miyake Katsunori、Fujie Tetsuo、Newman David J.、O’Keefe Barry R.、Lee Kuo-Hsiung、Nakagawa-Goto Kyoko
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 8 Pages: 2282-2286

    • DOI

      10.1021/acs.orglett.8b00624

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Total Synthesis of Antiproliferative Parvifloron F2018

    • Author(s)
      Saito Yohei、Goto Masuo、Nakagawa-Goto Kyoko
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 3 Pages: 628-631

    • DOI

      10.1021/acs.orglett.7b03763

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa2018

    • Author(s)
      Aimaiti Simayijiang、Suzuki Airi、Saito Yohei、Fukuyoshi Shuichi、Goto Masuo、Miyake Katsunori、Newman David J.、O’Keefe Barry R.、Lee Kuo-Hsiung、Nakagawa-Goto Kyoko
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 83 Issue: 2 Pages: 951-963

    • DOI

      10.1021/acs.joc.7b02951

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death2017

    • Author(s)
      Shiau Jeng-Yuan、Nakagawa-Goto Kyoko、Lee Kuo-Hsiung、Shyur Lie-Fen
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 34 Pages: 56942-56958

    • DOI

      10.18632/oncotarget.18183

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antitubulin effects of aminobenzothiophene-substituted triethylated chromones2017

    • Author(s)
      Kobayashi Yukiko、Saito Yohei、Goto Masuo、Nakagawa-Goto Kyoko
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 12 Pages: 2731-2735

    • DOI

      10.1016/j.bmcl.2017.04.055

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions2017

    • Author(s)
      Shiau Jeng-Yuan、Chang Yong-Qun、Nakagawa-Goto Kyoko、Lee Kuo-Hsiung、Shyur Lie-Fen
    • Journal Title

      Frontiers in Pharmacology

      Volume: 8 Pages: 1-15

    • DOI

      10.3389/fphar.2017.00398

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Corymbulosins D-H, 2-hydroxy- and 2-oxo-clerodane diterpenes from the bark of Laetia corymbulosa2017

    • Author(s)
      Suzuki A, Fukuyoshi S, Saito Y, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K
    • Journal Title

      Journal of Natural Products

      Volume: ASAP Issue: 4 Pages: 1065-1072

    • DOI

      10.1021/acs.jnatprod.6b01151

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] (-)-Neocaryachine, An antiproliferative pavine alkaloid from Cryptocarya laevigata Induces DNA Double-strand Breaks2017

    • Author(s)
      Suzuki Y, Saito Y, Goto M, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K
    • Journal Title

      Journal of Natural Products

      Volume: 80 Issue: 1 Pages: 220-224

    • DOI

      10.1021/acs.jnatprod.6b01153

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Novel Clerodane Diterpene from <i>Vitex cofassus</i>2017

    • Author(s)
      Rasyid FA, Fukuyoshi S, Ando H, Miyake K, Atsumi T, Fujie T, Saito Y, Goto M, Shinya T, Mikage M, Sasaki, Nakagawa-Gotoa K
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65 Issue: 1 Pages: 116-120

    • DOI

      10.1248/cpb.c16-00775

    • NAID

      130005187753

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phenylethylchromones with in vitro antitumor promoting activity from Aquilaria filarial2017

    • Author(s)
      Suzuki A, Miyake K, Saito Y, Faradiba, Tokuda H, Takeuchi M, Suzuki N, Ichiishi E, Fujie T, Goto M, Sasaki S, Nakagawa-Goto K
    • Journal Title

      Planta Medica

      Volume: 83 Issue: 03/04 Pages: 300-305

    • DOI

      10.1055/s-0042-110858

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Total synthesis and in vitro anti tumor-promoting activity of racemic acetophenone monomers from Acronychia trifoliolata2016

    • Author(s)
      Morita C, Kobayashi Y, Tokuda H, Saito Y, Miyake M, Suzuki N, Ichiishi E, Lee KH, Nakagawa-Goto K
    • Journal Title

      Journal of Natural Products

      Volume: 79 Issue: 11 Pages: 2890-2897

    • DOI

      10.1021/acs.jnatprod.6b00646

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Acetophenone monomers from Acronychia trifoliolata2016

    • Author(s)
      Miyake M, Suzuki A, Morita C, Goto M, Newman DJ, O’Keefe B, Morris-Natschke SL, Lee KH, Nakagawa-Goto K
    • Journal Title

      Journal of Natural Products

      Volume: 79 Issue: 11 Pages: 2883-2889

    • DOI

      10.1021/acs.jnatprod.6b00645

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Triethylated chromones with substituted naphthalenes as novel tubulin inhibitors2016

    • Author(s)
      Nakagawa-Goto K, Taniguchi Y, Watanabe Y, Oda A, Ohkoshi E, Hamel E, Lee KH, Goto M
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Pages: 6048-6057

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel sesquiterpene lactone analogues as potent anti-breast cancer agents2016

    • Author(s)
      Nakagawa-Goto K, Chen JY, Cheng YT, Lee WL, Takeya, M, Saito Y, Lee KH, Shyur LF
    • Journal Title

      Molecular Oncology

      Volume: - Issue: 6 Pages: 921-937

    • DOI

      10.1016/j.molonc.2016.03.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice2016

    • Author(s)
      Feng JH, Nakagawa-Goto K, Lee KH, Shyur LF
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: - Issue: 6 Pages: 1163-1176

    • DOI

      10.1158/1535-7163.mct-15-0973

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring2015

    • Author(s)
      Nakagawa-Goto K, Oda A, Hamel E, Ohkoshi E, Bastow KF, Lee KH, Goto M
    • Journal Title

      J Med Chem

      Volume: 58 Issue: 5 Pages: 2378-2389

    • DOI

      10.1021/jm501859j

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 熱帯雨林植物ハスノハギリ科Hernandia peltataの成分研究2018

    • Author(s)
      Simayijiang Aimaiti、斎藤洋平、後藤益生、David J. Newman、Barry R. O’Keefe、 Kuo-Hsiung Lee、後藤(中川)享子
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Noreremophilane誘導体の合成とトリプルネガティブ乳がん細胞選択的増殖抑制効果2018

    • Author(s)
      佐賀野桃子、齋藤洋平、後藤益生、後藤(中川)享子
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規ラクトン化合物Cryptolaevilactones AーCの合成と絶対立体構造の決定2018

    • Author(s)
      三浦悠太、齋藤洋平、後藤(中川)享子
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規ラクトン化合物Cryptolaevilactone M の合成と絶対立体構造の決定2018

    • Author(s)
      中野美咲、齋藤洋平、後藤(中川)享子
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ベンゾチオフェンフラボノイド誘導体のがん細胞増殖抑制効果と構造活性相関2018

    • Author(s)
      平澤幸香、谷口由花子、齋藤洋平、後藤益生、後藤(中川)享子
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 去勢抵抗性前立腺がん克服を目指したカルコン誘導体の創出2018

    • Author(s)
      齋藤洋平、溝上敦、泉浩二、内藤伶奈人、後藤 益生、後藤(中川)享子
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗腫瘍活性を有するパビンアルカロイドの合成、構造活性相関研究ならびに作用機序の解明2017

    • Author(s)
      三浦悠太、鈴木結貴、斎藤洋平、後藤益生、後藤(中川)享子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 去勢抵抗性前立腺がんに有効なフラボノイド誘導体の創出研究2017

    • Author(s)
      斎藤洋平、溝上 敦、泉 浩二、武澤 雄太、後藤益生、後藤(中川)享子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヤナギ科Laetia corymbulosaから単離された新規クレロダンジテルペン, corymbulosins D-Lと抗腫瘍活性2017

    • Author(s)
      鈴木愛理,SIMAYIJIANG AIMAITI、福吉修一、斎藤洋平、後藤益生、David J. Newman、Barry R. O’Keefe、 Kuo-Hsiung Lee、後藤(中川)享子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 4-epi-Parvifloron類の合成と抗トリプルネガティブ乳がん選択性向上にむけての試み2017

    • Author(s)
      宮島由衣、竹谷宗久、斎藤洋平、後藤益生、後藤(中川)享子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 熱帯雨林植物の成分研究:Acronychia trifoliolata に含有されるアセトフェノンダイマー2017

    • Author(s)
      三宅克典、鈴木愛理、後藤益生、David J. Newman、Gordon M. Cragg、Barry O’Keefe、Kuo-Hsiung Lee、後藤(中川)享子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生理活性ジテルペン、パルビフロロンFの全合成2017

    • Author(s)
      齋藤洋平、後藤益生、後藤(中川)享子
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      東京
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 4-epi-Parvifloron類の合成と抗トリプルネガティブ乳がん選択性向上にむけての試み2017

    • Author(s)
      宮島由衣、 竹谷宗久、 斎藤洋平、 後藤益生、 後藤(中川)享子
    • Organizer
      第15回次世代を担う若手のためのフィジカル・フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Total Synthesis of Bioactive Diterpene, Parvifloron F2017

    • Author(s)
      Saito Y, Goto M, Nakagawa-Goto K
    • Organizer
      254th ACS National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然物基本骨格から細胞周期阻害剤の創成2017

    • Author(s)
      後藤(中川)享子
    • Organizer
      第129回薬学会北陸支部例会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ズキ科Alangium longiforumから単離されたアルカロイド成分2016

    • Author(s)
      竹内美沙、斎藤洋平、後藤益生、David J. Newman、Gordon M. Cragg、Barry O’Keefe、Kuo-Hsiung Lee、後藤(中川)享子
    • Organizer
      日本生薬学会第63回年会
    • Place of Presentation
      富山
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Parvifloron類を含むアビエタン誘導体の抗腫瘍活性評価と構造活性相関2016

    • Author(s)
      宮島由衣、斎藤洋平、竹谷宗久、後藤益生、後藤(中川)享子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Acronychia trifoliolata含有のアセトフェノンモノマー体の合成2016

    • Author(s)
      森田千尋、小林佑希子、斎藤洋平、三宅克典、後藤(中川)享子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 熱帯雨林植物の成分研究 Acronychia trifoliolataに含有されるアセトフェノンモノマー2016

    • Author(s)
      三宅克典、鈴木愛理、後藤益生、David J.Newman、Gordon M. Cragg、Barry O’Keefe、Kuo-Hsiung Lee、後藤(中川)享子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] インドネシア産Agarwoodから単離された2-(2-Phenylethyl)chromone類と発がん抑制効果2016

    • Author(s)
      鈴木愛理,FARADIBA AbdulRasyid、三宅克典、斎藤洋平、徳田春邦、鈴木信孝、後藤益生、 佐々木陽平、後藤(中川)享子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice2015

    • Author(s)
      Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      アメリカ ボストン
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Parviflorone 類の全合成と triple negative 乳がんを標的とした抗腫瘍活性評価2015

    • Author(s)
      竹谷宗久、斎藤洋平、後藤益生、後藤(中川)享子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] トリプルネガティブ乳がん選択的抗腫瘍活性を有するパルビフロロン誘導体2018

    • Inventor(s)
      後藤享子、斎藤洋平、宮島由衣
    • Industrial Property Rights Holder
      後藤享子、斎藤洋平、宮島由衣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] エピミノジベンゾアヌレン骨格を有する新規抗がん剤候補2016

    • Inventor(s)
      後藤享子、鈴木結貴、齋藤洋平
    • Industrial Property Rights Holder
      後藤享子、鈴木結貴、齋藤洋平
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-01
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] Preparation of novel sesquiterpene derivatives and their use in inflammation and cancer treatment2015

    • Inventor(s)
      Lee KH, Nakagawa-Goto K, et al
    • Industrial Property Rights Holder
      Lee KH, Nakagawa-Goto K, et al
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Novel sesquiterpene derivatives and their use in inflammation or cancer treatment2015

    • Inventor(s)
      Shyur LF, Nakagawa-Goto K, et al
    • Industrial Property Rights Holder
      Shyur LF, Nakagawa-Goto K, et al
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-06
    • Related Report
      2015 Annual Research Report
    • Overseas

URL: 

Published: 2013-05-21   Modified: 2022-02-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi