| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
The immunoproteasome plays an important role in antigen processing and T cell generation. Recently, immunoproteasome-specific inhibitors have been proposed to have effects on diseases including immune function. In this study, we searched for selective immunoproteasome inhibitors from natural sources. In screening, we selected the extracts of natural sources that inhibited the immunoproteasome more potent than the constitutive proteasome and purified inhibitors. We succeeded in isolating new proteasome inhibitors, whereas they were found to be non-selective inhibitors.
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