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Search for drug leads of autoimmune disease targeting the immunoproteasome

Research Project

Project/Area Number 25293025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Natural medicines
Research InstitutionKumamoto University

Principal Investigator

Tsukamoto Sachiko  熊本大学, 生命科学研究部(薬), 教授 (40192190)

Co-Investigator(Renkei-kenkyūsha) YOKOSAWA Hideyoshi  愛知学院大学, 薬学部, 教授 (90012765)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords免疫プロテアソーム / 自己免疫疾患 / 創薬 / 天然資源 / ユビキチンープロテアソームシステム
Outline of Final Research Achievements

The immunoproteasome plays an important role in antigen processing and T cell generation. Recently, immunoproteasome-specific inhibitors have been proposed to have effects on diseases including immune function. In this study, we searched for selective immunoproteasome inhibitors from natural sources. In screening, we selected the extracts of natural sources that inhibited the immunoproteasome more potent than the constitutive proteasome and purified inhibitors. We succeeded in isolating new proteasome inhibitors, whereas they were found to be non-selective inhibitors.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (69 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (3 results) Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 18 results,  Open Access: 10 results,  Acknowledgement Compliant: 7 results) Presentation (46 results) (of which Int'l Joint Research: 4 results,  Invited: 14 results) Remarks (2 results)

  • [Int'l Joint Research] Sam Ratulangi University(Indonesia)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] National Research Centre/Cairo University(Egypt)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Naturalis Biodiversity Center(オランダ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Search for Inhibitors of the Ubiquitin–Proteasome System from Natural Sources for Cancer Therapy2016

    • Author(s)
      S. Tsukamoto
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 2 Pages: 112-118

    • DOI

      10.1248/cpb.c15-00768

    • NAID

      130005121724

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carteritins A and B, cyclic heptapeptides from the marine sponge Stylissa carteri2016

    • Author(s)
      A. H. Afifi, A. H. El-Desoky, H. Kato, R. E. P. Mangindaan, N. J. de Voogd, N. M. Ammar, M. S. Hifnawy, S. Tsukamoto
    • Journal Title

      Tetrahedron Lett.

      Volume: 57 Issue: 11 Pages: 1285-1288

    • DOI

      10.1016/j.tetlet.2016.02.031

    • NAID

      120006897991

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Taichunamides: prenylated indole alkaloids from Aspergillus taichungensis (IBT 19404)2016

    • Author(s)
      I. Kagiyama, H. Kato, T. Nehira, J. C. Frisvad, D. H. Sherman, R. M. Williams, S. Tsukamoto
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Pages: 1128-1132

    • NAID

      120006897972

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Collective Synthesis and Biological Evaluation of Tryptophan-based Dimeric Diketopiperazine Alkaloids2016

    • Author(s)
      Shine Tadano, Yukihiro Sugimachi, Michinori Sumimoto, Sachiko Tsukamoto, Hayato Ishikawa*
    • Journal Title

      Chemistry A European Journal

      Volume: 22 Issue: 4 Pages: 1277-1291

    • DOI

      10.1002/chem.201503417

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Niphateolide A: isolation from the marine sponge Niphates olemda and determination of its absolute configuration by an ECD analysis2015

    • Author(s)
      H. Kato, T. Nehira, K. Matsuo, T. Kawabata, Y. Kobashigawa, H. Morioka, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, H. Yokosawa, S. Tsukamoto
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 38 Pages: 6956-6960

    • DOI

      10.1016/j.tet.2015.07.009

    • NAID

      120006897988

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors2015

    • Author(s)
      A. Noda, E. Sakai, H. Kato, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, H. Yokosawa, S. Tsukamoto
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25

    • NAID

      120006897981

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids, from the Indonesian marine sponges, Acanthostrongylophora ingens.2014

    • Author(s)
      A. H. El-Desoky, H. Kato, K. Eguchi, T. Kawabata, Y. Fujiwara, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, M. Takeya, H. Yokosawa, S. Tsukamoto
    • Journal Title

      J. Nat. Prod.

      Volume: 77 Issue: 6 Pages: 1536-1540

    • DOI

      10.1021/np500290a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens.2014

    • Author(s)
      A. Furusato, H. Kato, T. Nehira, K. Eguchi, T. Kawabata, Y. Fujiwara, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, M. Takeya, H. Yokosawa, S. Tsukamoto
    • Journal Title

      Org. Lett.

      Volume: 16 Issue: 15 Pages: 3888-3891

    • DOI

      10.1021/ol5015569

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Halenaquinone inhibits RANKL-induced osteoclastogenesis2014

    • Author(s)
      S. Tsukamoto, T. Takeuchi, T. Kawabata, H. Kato, M. Yamakuma, K. Matsuo, A. H. El-Desoky, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, Y. Arata, H. Yokosawa.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 22 Pages: 5315

    • DOI

      10.1016/j.bmcl.2014.09.043

    • NAID

      120006897978

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1-Hydroxyethylhalenaquinone: a new proteasome inhibitor from the marine sponge Xestospongia sp.2014

    • Author(s)
      M. Yamakuma, H. Kato, K. Matsuo, A. H. El-Desoky, T. Kawabata, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, H. Yokosawa, S. Tsukamoto
    • Journal Title

      Heterocycles

      Volume: 89 Issue: 11 Pages: 2605-2610

    • DOI

      10.3987/com-14-13087

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Variabines A and B, new β-carboline alkaloids from the marine sponge Luffariella variabilis.2014

    • Author(s)
      E. Sakai, H. Kato, H. Rotinsulu, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, H. Yokosawa, S. Tsukamoto
    • Journal Title

      J. Nat. Med.

      Volume: 68 Pages: 215-219

    • NAID

      120006897985

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aaptoline A, a new quinoline alkaloid from the marine sponge Aaptos suberitoides2014

    • Author(s)
      Y.Kudo, R.E.P.Mangindaan, S.Tsukamoto
    • Journal Title

      Heterocycles

      Volume: 88 Issue: 1 Pages: 591-594

    • DOI

      10.3987/com-13-s(s)3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reticulatins A and B and hyrtioreticulin F from the marine sponge Hyrtios reticulatus2013

    • Author(s)
      K.Imada, S.Tsukamoto
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 34 Pages: 7051-7055

    • DOI

      10.1016/j.tet.2013.06.043

    • NAID

      120006897987

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo2013

    • Author(s)
      K.Eguchi, R.E.P.Mangindaan, S.Tsukamoto
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21 Issue: 13 Pages: 3831-3838

    • DOI

      10.1016/j.bmc.2013.04.025

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B.2013

    • Author(s)
      J. D. Sunderhaus, T. J. McAfoos, J. M. Finefield, H. Kato, S. Li, S. Tsukamoto, D. H. Sherman, R. M. Williams
    • Journal Title

      Org. Lett.

      Volume: 15 Issue: 1 Pages: 22-25

    • DOI

      10.1021/ol302901p

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spongiacidin C, a bromopyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor2013

    • Author(s)
      M.Yamaguchi, R.E.P.Mangindaan, S.Tsukamoto
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 13 Pages: 3884-3886

    • DOI

      10.1016/j.bmcl.2013.04.066

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Siladenoserinols A-L: New Sulfonated Serinol Derivatives from a Tunicate as Inhibitors of p53-Hdm2 Interaction.2013

    • Author(s)
      Nakamura, Y.
    • Journal Title

      Org. Lett.

      Volume: 15 Issue: 2 Pages: 322-325

    • DOI

      10.1021/ol3032363

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Himeic acids E-G, new 4-pyridone derivatives from a culture of Aspergillus sp.2013

    • Author(s)
      T. Kuwana, M. Miyazaki, H. Kato, S. Tsukamoto
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 61 Pages: 105-107

    • NAID

      130003360720

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] p53を安定化させる脱ユビキチン化酵素USP7阻害物質の探索2016

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第136年会シンポジウム「創薬研究における天然物化学のミッションと新潮流」
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 海生糸状菌Aspergillus sp. MF275由来himeic acidの生合成研究2016

    • Author(s)
      橋元誠、勝木理子、加藤光、塚本佐知子、藤井勲
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] インドネシア産Dysidia属海綿由来新規セスキテルペンの構造2016

    • Author(s)
      鳥井万純、加藤光、塚本佐知子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] インドネシア産海綿から単離した4種の新規セスタテルペンの構造2016

    • Author(s)
      Ahmed H. Afifi、加藤光、塚本佐知子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Drug discovery targeting the ubiquitin-proteasome system from marine organisms2015

    • Author(s)
      Sachiko Tsukamoto
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Honolulu (USA) (Hilton Hawaiian Village)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] トリプトファン由来二量体型アルカロイド類の網羅的合成と生物活性評価2015

    • Author(s)
      只野慎治、杉町幸寛、塚本佐知子、石川勇人
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉(幕張国際研修センター)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 海洋生物は薬用資源の宝庫.2015

    • Author(s)
      塚本佐知子
    • Organizer
      平成27年度熊本大学東京オフィスセミナー「天然物創薬のフロンティア~熊本大学から世界に発信する拠点形成研究~」
    • Place of Presentation
      東京(東京工業大学キャンパスイノベーションセンター1階 国際会議室)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 海綿Petrosia alfianiから得られた新規xestoquinone類縁体の構造と生物活性2015

    • Author(s)
      田之頭夏希、久木田沙菜子、加藤光、根平達夫、塚本佐知子
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜(長良川国際会議場)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 海綿 Petrosia alfiani から得られた新規 xestoquinone 二量体の構造と生物活性2015

    • Author(s)
      久木田沙菜子、Ahmed H. El-desoky、加藤光、塚本佐知子
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜(長良川国際会議場)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 3種のAspergillus属真菌が産生するnotoamidesの構造と推定生合成経路2015

    • Author(s)
      賀儀山一平、 加藤光、 中原高志、 松尾佳苗、 杉本佳代、 塚本佐知子
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      横浜(神奈川県民ホール)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Search for proteasome inhibitors from marine organisms2015

    • Author(s)
      Sachiko Tsukamoto, Ahmed H. El-Desoky, Akane Furusato, Michiko Yamakuma, Ai Noda, Eriko Sakai, Remy E. P. Mangindaan, Tetsuro Kawabata, Hikaru Kato
    • Organizer
      ISPSA2015 TOKUSHIMA
    • Place of Presentation
      徳島(徳島文理大学)
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation of strongylophorines from the marine sponge Petrosia corticata, as proteasome inhibitors2015

    • Author(s)
      Sachiko Tsukamoto, Ai Noda, Eriko Sakai, Hikaru Kato
    • Organizer
      ASP 2015 Annual Meeting
    • Place of Presentation
      Copper Mountain (CO, USA) (Copper Mountain Resort & Conference Center)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Search for inhibitors of the ubiquitin-proteasome system from the natural sources for drug development2015

    • Author(s)
      Sachiko Tsukamoto
    • Organizer
      Organic Seminar in Colorado State University
    • Place of Presentation
      Fort Collins (CO, USA) (Colorado State University)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Aspergillus taichungensisが生成する新規アルカロイドの構造について2015

    • Author(s)
      塚本佐知子、賀儀山一平、加藤光
    • Organizer
      第10回化学生態学研究会
    • Place of Presentation
      函館(湯の川プリンスホテル渚亭
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Aspergillus taichungensis から得られた新規ジテルペンの構造と生物活性について2015

    • Author(s)
      瀬邊 桃菜、賀儀山 一平、加藤 光、川畑 哲郎、塚本 佐知子
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸(神戸学院大学・兵庫医療大学)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Didemnum 属群体ボヤ由来新規serinolipidの構造2015

    • Author(s)
      鳥井万純、中村優一、加藤光、塚本佐知子
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸(神戸学院大学・兵庫医療大学)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海綿Petrosia corticataに含まれるメロジテルペンstrongylophorinesの構造と活性2014

    • Author(s)
      野田愛、坂井恵理子、松尾佳苗、○加藤光、川畑哲郎、塚本佐知子
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      福岡(第一薬科大学)
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Xestospongia属海綿から得られた新規プロテアソーム阻害物質1-hydroxyetylhalenaquinoneについて2014

    • Author(s)
      山隈理子、松尾佳苗、Ahmed H. El-Desoky、川畑哲郎、加藤光、塚本佐知子
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      福岡(第一薬科大学)
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海綿 Petrosia alfiani から得られた新規 xestoquinone 類縁体2014

    • Author(s)
      田之頭夏希、加藤光、塚本佐知子
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      福岡(第一薬科大学)
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規manzamine類縁化合物の生物活性と推定生合成経路2014

    • Author(s)
      塚本佐知子
    • Organizer
      第20回天然物の開発と応用シンポジウム「モノトリの新展開」
    • Place of Presentation
      東京(東京大学弥生講堂一条ホール)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ユビキチン化を標的とする創薬2014

    • Author(s)
      塚本佐知子
    • Organizer
      第37回日本分子生物学会年会ワークショップ企画「ケミストリーを戦略としたシグナル伝達研究」
    • Place of Presentation
      横浜(横浜パシフィコ)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] パソコンでできるECDスペクトルシミュレーションによる有機化合物の絶対配置決定2014

    • Author(s)
      根平達夫、松尾光一、加藤光、塚本佐知子、伊藤哲朗、橋本勝
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知(高知県民文化ホール)
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海綿Acanthostrongylophora ingensから得られた新規manzamine類縁体の構造と生物活性2014

    • Author(s)
      古里あかね、Ahmed Hamed Eldesoky、加藤光、江口啓介、藤原章雄、川畑哲郎、竹屋元裕、塚本佐知子
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知(高知県民文化ホール)
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海洋資源からの医薬シーズの探索2014

    • Author(s)
      塚本佐知子
    • Organizer
      徳島文理大学学部・大学院特別講演会
    • Place of Presentation
      徳島(徳島文理大学)
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Xestospongia属海綿由来halenaquinone 関連化合物によるプロテアソーム阻害活性について2014

    • Author(s)
      山隈理子、松尾佳苗、Ahmed H. Eldesoky、川畑哲郎、加藤光、塚本佐知子
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡(福岡大学薬学部)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 海綿Petrosia corticataから得られたstrongylophorinesの生物活性2014

    • Author(s)
      野田愛、坂井恵理子、松尾佳苗、加藤光、川畑哲郎、塚本佐知子
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡(福岡大学薬学部)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] ユビキチン-プロテアソームシステムに対する阻害剤の開発2014

    • Author(s)
      塚本佐知子、横沢英良
    • Organizer
      第19回日本病態プロテアーゼ学会 学術集会シンポジウム「ユビキチンとプロテアソーム研究の最前線」
    • Place of Presentation
      大阪(千里ライフサイエンスセンター)
    • Year and Date
      2014-08-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] インドネシアの海洋天然薬物資源調査2014

    • Author(s)
      塚本佐知子
    • Organizer
      第4回天然物パワーシンポジウム「海外学術調査と天然物化学」
    • Place of Presentation
      東京(東京大学弥生講堂一条ホール)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新規マンザミン類の構造と生物活性2014

    • Author(s)
      塚本佐知子
    • Organizer
      第9回化学生態学研究会
    • Place of Presentation
      函館(湯の川プリンスホテル渚亭)
    • Year and Date
      2014-06-26 – 2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Two new manzamine alkaloids isolated from the Indonesian marine sponges Acanthostrongylophora ingens2014

    • Author(s)
      Ahmed H. El-Desoky, Keisuke Eguchi, Tetsuro Kawabata, Hikaru Kato, Yukio Fujiwara, Motohiro Takeya, and Sachiko Tsukamoto
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本(熊本大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] インドネシア産Amphimedon属海綿から得られた新規骨格を有するジテルペンの構造と生物活性2014

    • Author(s)
      加藤光、川畑哲郎、塚本佐知子
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本(熊本大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Aspergillus taichungensisが産生するnotoamide類縁体の構造について2014

    • Author(s)
      賀儀山一平、中原高志、加藤光、塚本佐知子
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本(熊本大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] インドネシア産海綿Plakortis berguistaeから得られた新規polyketide endoperoxides の構造と抗菌活性2014

    • Author(s)
      具志堅政樹、桑名寿幸、川畑哲郎、加藤光、塚本佐知子
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本(熊本大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] マクロファージ泡沫化阻害活性を示す bastadin誘導体の構造と活性について2014

    • Author(s)
      江口 啓介、藤原 章雄、川畑哲郎、加藤 光、竹屋 元裕、塚本 佐知子
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本(熊本大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 真菌由来アルカロイドの鏡像異性体に関する研究2014

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本(熊本大学)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ユビキチン化を標的とする創薬研究2014

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本(熊本大学)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 海綿から得られたUSP7阻害物質spongiacidin C2013

    • Author(s)
      塚本佐知子
    • Organizer
      第8回化学生態学研究会
    • Place of Presentation
      函館(湯の川プリンスホテル渚亭)
    • Related Report
      2013 Annual Research Report
  • [Presentation] マンザミンによる動脈硬化改善作用について2013

    • Author(s)
      塚本佐知子
    • Organizer
      第8回化学生態学研究会
    • Place of Presentation
      函館(湯の川プリンスホテル渚亭)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Search for new inhibitors of the ubiquitin-proteasome system from natural sources for drug development2013

    • Author(s)
      Sachiko Tsukamoto
    • Organizer
      The 35nd NAITO COBFERENCE ON The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles
    • Place of Presentation
      札幌(シャトレーゼ・ガトーキングダム)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Xestoquinone 二量体の絶対立体配置の決定と新規 xestoquinone類縁体の構造2013

    • Author(s)
      田之頭夏希、加藤光、塚本佐知子
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      石狩郡当別町(北海道医療大学当別キャンパス)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海綿Hyrtios reticulatus由来reticulatins A, Bおよびhyrtioreticulin Fの絶対立体配置の決定2013

    • Author(s)
      坂井恵理子、今田久美子、根平達夫、川端哲郎、加藤光、塚本佐知子
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      石狩郡当別町(北海道医療大学当別キャンパス)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Search for new drug leads, which can enhance the effect of p53, from marine organisms2013

    • Author(s)
      Sachiko Tsukamoto, Hikaru Kato, and Tetsuro Kawabata
    • Organizer
      XIV International Symposium on Marine Natural Products
    • Place of Presentation
      La Toja Island (Spain) (Hotel Hesperia La Toja)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海綿Acanthostrongylophora ingens由来manzamineの動脈硬化抑制作用と新規manzamine類縁体の構造2013

    • Author(s)
      加藤光、江口啓介、古里あかね、藤原章雄、根平達夫、竹屋元裕、塚本佐知子
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      京都(同志社大学寒梅館)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脱ユビキチン化酵素USP7阻害物質spongiacidin Cの海綿からの単離と活性について2013

    • Author(s)
      山口 道考、塚本 佐知子
    • Organizer
      第5回食品薬学シンポジウム
    • Place of Presentation
      京都(京都大学薬学部記念講堂)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Marine Natural Products Inhibiting the Ubiquitin-proteasome System2013

    • Author(s)
      Sachiko Tsukamoto
    • Organizer
      International Symposium on Natural Products Chemistry and Chemical Biology 2013
    • Place of Presentation
      名古屋(ホテルルブラ王山)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 海洋生物からのモノトリに関する最近の話題

    • Author(s)
      塚本佐知子
    • Organizer
      理研シンポジウム「第14回 分析・解析技術と化学の最先端」
    • Place of Presentation
      和光(理化学研究所 鈴木梅太郎記念ホール)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 熊本大学大学院生命科学研究部天然薬物学分野ホームページ

    • URL

      http://kumamoto-natmed.net/index.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 熊本大学大学院生命科学研究部天然薬物学分野HP

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/shoyaku/site/TOP.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2022-02-01  

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