Multifaceted approaches to develop novel antibacterial seeds against drug-resistant bacterial pathogens
| Project/Area Number |
25293026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
ICHIKAWA Satoshi 北海道大学, 薬学研究科(研究院), 教授 (60333621)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 天然物 / 抗菌剤 / 有機合成 / 抗菌薬 / 薬剤耐性 / 創薬化学 |
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| Outline of Final Research Achievements |
a) Structural simplification of muraymycins and caprazamycins have been investigated to develop analogues possessing antibacterial activity against drug-resistant bacteria such as MRSA and VRE with enough metabolic stability as well as reduced toxicity against human cells. b) Efficient synthetic strategy toward the synthesis of plusbacin A3, which is applicable to the synthesis of a range of analogues, has been developed. c) Total synthesis of quinaldopeptin has been developed via solid-phase synthesis. A range of analogues was synthesized and their antibacterial activity was evaluated to find a potent analogue with superior antibacterial activity than that of natural product.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa.2014
Author(s)
Takeoka, Yusuke; Tanino, Tetsuya; Sekiguchi, Mitsuaki; Yonezawa, Shuji; Sakagami, Masahiro; Takahashi, Fumiyo; Togame, Hiroko; Tanaka, Yoshikazu; Takemoto, Hiroshi; Ichikawa, Satoshi*; Matsuda. Akira.
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Journal Title
ACS Med. Chem. Lett.
Volume: 5
Issue: 5
Pages: 556-560
DOI
Related Report
Peer Reviewed
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[Presentation] Synthetic study of plusbacin A32015
Author(s)
Katsuyama, A.; Matsuda, A.; Ichikawa, S.
Organizer
PACIFICHEM, The International Chemical Congress of Pacific Basin Societies 2015 (Poster Presentation)
Place of Presentation
Honolulu (Hawaii, USA)
Year and Date
2015-12-21
Related Report
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