Estrogen-induced neural signaling and behavioral development
| Project/Area Number |
25293031
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental and hygienic pharmacy
|
|---|
| Research Institution | Gifu Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中西 剛 岐阜薬科大学, 薬学部, 准教授 (50303988)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
|---|
| Keywords | エストロゲン / 性分化 / 脳 / 胎生期影響 / 臨界期 |
|---|
| Outline of Final Research Achievements |
The neural mechanism controlling sexual behavior in mice are sexually differentiated by the actions of sex steroids during the critical periods. However the physiological significance of fetal estrogen effects on the sexually dimorphic behavior remain poorly unknown. To study the direct effect of estrogen exposure in the fetal period on the sexually dimorphic behavior, we generated a transgenic mouse expressing EGFP-tagged aromatase, which converts androgen to estrogen, specifically in the placenta under the control of murine placental lactogen 2 promoter. Mice normally cannot produce estrogen in the placenta because lack of placental aromatase, but ArE-TG mice can produce estrogen in the placenta and are exposed to excessive estrogens from the placenta in the fetal periods. As a result, we found estrogen responsive positive cells in sexually dimorphic nucleus of fetal brain. Our findings suggest that the prenatal actions of estrogen may be involved in the sexually dimorphic behavior.
|
Report
(5 results)
Research Products
(46 results)
-
-
-
-
[Journal Article] Germline recombination in a novel Cre transgenic line, Prl3b1-cre mouse.2016
Author(s)
Al-Soudy AS, Hiromori Y, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki Hi, Yoshiki A, Nagase H, Nakanishi T, Takahashi S, Oishi H, Sugiyama F.
-
Journal Title
Genesis.
Volume: 54(7)
Issue: 7
Pages: 389-97
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
[Journal Article] Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds.2015
Author(s)
Harada, S., Hiromori, Y., Nakamura, S., Kawahara, K., Fukakusa, S., Maruno, T., Noda, M., Uchiyama, S., Fukui, K., Nishikawa, J., Nagase, H., Kobayashi, Y., Yoshida, T., Ohkubo, T., Nakanishi, T.,
-
Journal Title
Sci. Rep.
Volume: 5:8520
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding2014
Author(s)
Gutierrez-Mazariegos J, Kumar Nadendla E, Lima D, Kane M, Nishikawa J, Hiromori Y, Nakanishi T, Santos MM, Castro LFC, Bourguet W, Schubert M, Laudet V
-
Journal Title
Endocrinology
Volume: 155
Issue: 11
Pages: 4275-4286
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 卵巣機能によるTPT毒性発現修飾2014
Author(s)
大塚佑基、青木 明、中西 剛、永瀬久光
Organizer
第４回メタロミクス研究フォーラム
Place of Presentation
武蔵野大学（東京都西東京市）
Year and Date
2014-11-07 – 2014-11-08
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
