Strategy for overcoming Alzheimer's disease based on Zn2+-mediated cognitive decline
| Project/Area Number |
25293032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 亜鉛 / アミロイドβ / 海馬 / アルツハイマー病 / 記憶 / 認知機能 / 細胞外Zn2+ / 海馬歯状回 / 亜鉛シグナリング |
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| Outline of Final Research Achievements |
The hippocampus plays important roles for spatial and declarative memory. Zn2+ is released from glutamatergic (zincergic) neuron terminals in the hippocampus and serves as a signal factor. Synaptic Zn2+ homeostasis is critical for cognitive activity in the hippocampus. Amyloid-β (Aβ) is a candidate for the pathogenesis of Alzheimer’s disease (AD) and interacts with Zn2+. Aβ1-42 interacted with extracellular Zn2+ and was taken up into dentate granule cells, followed by transiently cognitive decline via attenuated LTP. Zn-Aβ1-42-mediated cognitive decline was rescued by extracellular and intracellular Zn2+ chelators. The present study indicates that extracellular Zn2+ in the hippocampus is a therapeutic target for AD.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Preventive effect of 3,5-dihydroxy-4-methoxybenzyl alcohol and zinc, Pacific oyster components, on glutamatergic neuron activity in the hippocampus2015
Author(s)
Haruna Tamano, Yukina Shakushi, Mitsugu Watanabe, Kazumi Ohashi, Chihiro Uematsu, Tadamune Otsubo, Kiyoshi Ikeda, and Atsushi Takeda
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Journal Title
Biol. Bul.
Volume: 229
Pages: 282-288
Related Report
Peer Reviewed
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[Journal Article] Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary α-amylase activity, trait anxiety and subjective stress2013
Author(s)
Keiko Unno, Naoki Tanida, Naoto Ishii, Hiroyuki Yamamoto, Kazuaki Iguchi, Minoru Hoshino, Atsushi Takeda, Hayato Ozawa, Tsutomu Ohkubo, Lekh R Juneja, Hiroshi Yamada
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Journal Title
Pharmacol. Biochem. Behav.
Volume: 111
Pages: 128-135
Related Report
Peer Reviewed
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