| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
This research was aimed to explore specific inhibitors of hepatic production of indoxyl sulfate, a sulfate-conjugated uremic solute, taht are involved in renal dysfuntion and acute kidney injury associated with uremia. By using the screening system for indoxyl sulfate production, we found that polyphenolic compounds and fenmic acid agent had potent inhibitory effects on hepatic indoxyl sulfate production. Administration of these polyphenols to rats with acute kidney injury ameliorated the disturbed renal function, suggesting that these approaches could be a useful strategy to develop therapeutic drugs for kidney injuries and/or dieases with uremia.
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