| Budget Amount *help |
¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Though the apical membrane of the gastric parietal cell is exposed to the severe pH fluid (pH 0.8), the cell is not usually damaged by acid, but its mechanism has not been elucidated. We previously found that the unidentified Cl- channel in the basolateral membrane of gastric parietal cells participates in the cytoprotective mechanism. In this study, we clarified the following points: 1) Gastric tubulovesicles have variety in their characteristics, and the expression pattern of ion transporting proteins is different among the vesicles. 2) A Cl- channel function of SLC26A7 in the basolateral membrane is essential to the cytoprotective mechanism of gastric parietal cells. 3) The sialic acid at the end of the carbohydrate chain in gastric proton pump beta-subunit may be important for regulation of the pump activity and the cytoprotective mechanism.
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