Sleepiness and l-carnitine: mechanism of action and clinica efficacyl-carnitine

• Project/Area Number: 25293056
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: HONDA Makoto 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, プロジェクトリーダー (50370979)
• Co-Investigator(Kenkyū-buntansha): 児玉 亨 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (20195746)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 脂肪酸代謝 / カルニチン / ナルコレプシー / 睡眠脳波 / 脂質代謝 / 夜間睡眠 / 脳神経疾患 / 睡眠

Outline of Final Research Achievements

Sleepiness and L-carnitine: mechanism of action and clinical efficacy
We previously report the favorable effect of L-carnitine on the sleepiness of narcolepsy patients. We tried to address the mechanism and correlates of the efficacy of L-carnitine using animal model and objective measure on clinical study. L-carnitine improved CPT1 activity marker in brain and peripheral, and altered gene expression and metabolome such as dopamine and related genes. Sleep in narcolepsy-model mice actually improved during resting (light) period. About 40% of hypersomnia can benefit from L-carnitine. We tried to discriminate the L-carnitine responders in hypersomnia patients using clinical symptoms or EEG measures.

Research Products

• [Presentation] Sweet seeking and sleep stability in narcolepsy pateints. (2017)
  • Author(s): Honda M, Ito W,Ueno T, Kato N, Miyagawa T
  • Organizer: 1st Asian Narcolepsy & Hypersomnolence Society Meeting
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2017-03-24
  • Int'l Joint Research / Invited
• [Presentation] REM transition index (# sleep stage transitions from REM/REM duration) correlates with subjective nocturnal awakenings and is an independent risk factor for Narcolepsy Type1 (2016)
  • Author(s): Honda M, Sasaki K, Ueno T, Ito W, Kato N
  • Organizer: Sleep 2016
  • Place of Presentation: Denver, U.S.A.
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Presentation] Effect of L-carnitine on narcolepsy (2016)
  • Author(s): Honda M
  • Organizer: 8th Asian Narcolepsy Forum/ 4th International Pediatric Sleep Association Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-03-11
  • Int'l Joint Research / Invited
• [Presentation] ナルコレプシーにおける脂肪酸代謝異常とLカルニチンの効 (2015)
  • Author(s): 本多 真
  • Organizer: 第40回日本睡眠学会学術集会
  • Place of Presentation: 栃木県総合文化センター(栃木県・宇都宮市)
  • Year and Date: 2015-07-03
  • Invited
• [Presentation] 過眠を呈する睡眠障害の症状と病態 (2015)
  • Author(s): 本多 真
  • Organizer: つくばアカデミー・オブ・サイカイアトリー学術講演会
  • Place of Presentation: 秋葉原ＵＤXカンファレンス南ウイング(東京都千代田区)
  • Year and Date: 2015-05-29
  • Invited
• [Presentation] CPT1 activity is a risk factor for narcolepsy: possible contribution of dietary habit (2015)
  • Author(s): Honda M
  • Organizer: World Association of Sleep Medicine
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-03-25
  • Invited
• [Presentation] Decreased CPT1 function is associated with and a risk factor for narcolepsy and essential hypersomnia. (2014)
  • Author(s): Honda M, Miyagawa T, Shigematsu Y, Kodama T, Tokunaga K.
  • Organizer: Eeuropean Sleep Research Soceity, congress 2014
  • Place of Presentation: Tallinn, Estonia
  • Year and Date: 2014-09-19
• [Presentation] ナルコレプシーの症状と病態 (2014)
  • Author(s): 本多真
  • Organizer: 第６回ISMSJ学術集会
  • Place of Presentation: 神戸ファッションマート, 兵庫県神戸市
  • Year and Date: 2014-08-01
  • Invited
• [Presentation] Low long-chain acylcarnitines in narcolepsy.
  • Author(s): Honda M, Miyagawa T, Shigematsu Y, Tokunaga K
  • Organizer: 11th WFSBP
  • Place of Presentation: Kyoto
• [Presentation] Decreased long chain acylcarnitines in narcolepsy
  • Author(s): Honda M, Miyagawa T, Shigematsu Y, Tokunaga K
  • Organizer: Sleep2013
  • Place of Presentation: Baltimore, USA
• [Presentation] ナルコレプシー治療の変遷：過眠症状とその治療
  • Author(s): 本多真
  • Organizer: 第38回日本睡眠学会学術集会
  • Place of Presentation: 秋田
• [Remarks] 公益財団法人東京都医学総合研究所 睡眠プロジェクト
  • URL: http://www.igakuken.or.jp/sleep/