| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
Presynaptic differentiation is induced by an activation of small subset of cell adhesion molecules called synapse organizers. Using artificially induced hemi-synapses between recombinant synapse organizer-coated beads and cultured neurons, we identified components of presynaptic protein complexes formed on the cytoplasmic domain of synapse organizers on activation. Crystal structural analyses of presynaptic organizer PTPδ in complex with IL1RAPL1, IL-1RAcP or Slitrk2 and mutational analyses of these synapse organizers revealed structure-function relationships of synapse-organizing complexes for presynaptic differentiation.
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