Molecular mechanisms of presynaptic differentiation
Project/Area Number |
25293057
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | University of Toyama |
Principal Investigator |
YOSHIDA Tomoyuki 富山大学, 大学院医学薬学研究部(医学), 准教授 (90372367)
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Co-Investigator(Renkei-kenkyūsha) |
UEMURA TAKESHI 信州大学, 医学部, 准教授 (00372368)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | シナプス形成 / シナプスオーガナイザー / シナプス前終末 / シナプス小胞 / アクティブゾーン |
Outline of Final Research Achievements |
Presynaptic differentiation is induced by an activation of small subset of cell adhesion molecules called synapse organizers. Using artificially induced hemi-synapses between recombinant synapse organizer-coated beads and cultured neurons, we identified components of presynaptic protein complexes formed on the cytoplasmic domain of synapse organizers on activation. Crystal structural analyses of presynaptic organizer PTPδ in complex with IL1RAPL1, IL-1RAcP or Slitrk2 and mutational analyses of these synapse organizers revealed structure-function relationships of synapse-organizing complexes for presynaptic differentiation.
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Novel role of serine racemase in antiapoptosis and metabolism.2017
Author(s)
Talukdar, G., Inoue, R., Yoshida, T., Ishimoto, T., Yaku, K., Nakagawa, T., Mori, H.
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Journal Title
BBA - General Subjects
Volume: 1861
Issue: 1
Pages: 3378-3387
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion2015
Author(s)
Yamagata A., Sato, Y., Goto-Ito, S., Uemura, T., Maeda, A., Shiroshima, T., Yoshida, T., Fukai , S.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 9686-9686
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation2015
Author(s)
Yamagata A., Yoshida, T., Sato, Y., Goto-Ito, S., Uemura, T., Maeda, A., Shiroshima, T., Iwasawa-Okamoto, S., Mori, H., Mishina, M., Fukai , S.
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 6926-6926
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] IL1RAPL1 knockout mice show learning deficiency, memory decline, hyperactivity and reduced anxiety-like behaviours.2014
Author(s)
Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa, Masayoshi Mishina
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Journal Title
Scientific Reports
Volume: 4: 6613
Issue: 1
Pages: 6613-6613
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction.2014
Author(s)
Kinoshita K, Komatsu T, Nishide K, Hata Y, Hisajima N, Takahashi H, Kimoto K, Aonuma K, Tushima E, Tabata T, Yoshida T, Mori H, Nishida K, Yamaguchi Y, Ichida F, Fukurotani K, Inoue H, Nishida N.
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Journal Title
J Mol Cell Cardiol
Volume: 72
Pages: 273-280
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 小脳シナプス形成を制御するGluD2-Cbln1-neurexin接着分子複合体の構造基盤2015
Author(s)
植村健, 佐藤祐介, 山形敦史, 吉田知之, 後藤桜子, 前田亜沙美, 城島知子, 田渕克彦, 三品昌美, 深井周也.
Organizer
第38回日本分子生物学会年会 ワークショップ
Place of Presentation
神戸国際会議場, 神戸
Year and Date
2015-12-01
Related Report
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[Presentation] シナプス形成を司るIL1RAPL1-PTPδ複合体の構造基盤2015
Author(s)
吉田知之, 山形敦史, 佐藤祐介, 伊藤桜子, 植村健, 前田亜沙美, 城島知子, 岡本志穂, 森寿, 三品昌美, 深井周也
Organizer
第38回日本神経科学大会
Place of Presentation
神戸国際会議場, 神戸
Year and Date
2015-07-31
Related Report
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