| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
In this study, we have tried to reveal the roles of D-serine in the neural functions and dysfunctions and examined the roles of D-serine producing enzyme serine racemase (SR) in vivo. We have found the novel roles of SR and D-serine in D-aspartate production, pain regulation in the spinal chord, and barrier function in the skin. Furthermore, to analyze the molecular basis of D-serine dynamics regulation in the brain, we have tried to generate two new mouse models, 1) neuronal D-serine transporter (Asc-1) conditional knockout mouse and 2) astrocyte-selective expression of D-serine degradation enzyme (Dsd-1) in mouse.
We also developed a novel SR inhibitor which is effective to suppress over-excitation in the brain. This compound will be a lead drug expected to suppress neuronal excitotoxicity.
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