Development of a new drug for heart failure targeting phospholamban
| Project/Area Number |
25293062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
INUI Makoto 山口大学, 医学(系)研究科(研究院), 教授 (70223237)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIMURA Akio 山口大学, 大学院医学系研究科, 教授 (30194971)
KURAMASU Atsuo 山口大学, 大学院医学系研究科, 准教授 (90302091)
HONDA Takeshi 山口大学, 大学院医学系研究科, 講師 (30457311)
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| Co-Investigator(Renkei-kenkyūsha) |
NAMBA Keiichi 大阪大学, 大学院生命機能研究科, 教授 (30346142)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 心不全治療薬 / ホスホランバン / アプタマー / 創薬 / 結晶構造解析 |
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| Outline of Final Research Achievements |
In the failing heart, the Ca2+ pumping activity of the intracellular Ca2+ storage site, the sarcoplasmic reticulum (SR), is significantly reduced, resulting in dysfunction of cardiomyocytes due to intracellular Ca2+ overload. The Ca2+ pumping activity of SR is regulated by phospholamban, which is a potential target to the treatment of heart failure. Here we studied a phospholamban inhibitor which augments the Ca2+ pumping activity of SR, including a phospholamban aptamer. Our results including optimization of a phospholamban aptamer provide a basis for the development of new therapeutic agents for heart failure.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice.2015
Author(s)
Ishiguro S, Yoshimura K, Tsunedomi R, Oka M, Takao S, Inui M, Kawabata A, Wall T, Magafa V, Cordopatis P, Tzakos AG, Tamura M.
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Journal Title
Cancer Biol Ther.
Volume: 16
Issue: 2
Pages: 307-316
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2+ transients and contractile function in cardiomyocytes.2014
Author(s)
Sakai, H., Ikeda, Y., Honda, T., Tanaka, Y., Shiraishi, K., and Inui, M.
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Journal Title
J. Mol. Cell. Cardiol.
Volume: 76
Pages: 177-185
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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