Elucidation of physiological significance of LOX-1 binding molecules

• Project/Area Number: 25293063
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Shinshu University (2014-2015); National Cardiovascular Center Research Institute (2013)
• Principal Investigator: SAWAMURA Tatsuya 信州大学, 学術研究院医学系, 教授 (30243033)
• Research Collaborator: KAKINO Akemi 信州大学, 先鋭領域融合研究群バイオメディカル研究所, 助教 (00534637) ; FUJITA Yoshiko 信州大学, 学術研究院医学系, 助教 (30416218)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: LOX-1 / GPCR / クロストーク / 変性LDL受容体 / 複合体形成 / 循環器・高血圧

Outline of Final Research Achievements

First, we investigated the significance of GPCR-LOX-1 complex formation. We found that LOX-1 could form a complex with a GPCR X as well as with the angiotensin II receptor AT1. Binding of oxidized LDL to LOX-1 induced GPCR X-mediated intracellular signal transduction as was the case with AT1. Concerning AT1-LOX-1 complex formation, we witnessed that administration of an AT1 antagonist to SHRSP suppressed high fat diet-induced arterial lipid deposition even at doses that do not affect blood pressure. Second, we found that association of LOX-1 and coagulation factors promotes thrombin generation depending on the doses of LOX-1 and a coagulation factor.
Association of LOX-1 with the above molecules to induce various biological effects would illustrate a wide variety of LOX-1 roles in pathology not limited to atherosclerosis.

Research Products

• [Journal Article] High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study (2016)
  • Author(s): Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 10 Pages: 1222-1226
  • DOI: 10.5551/jat.32466
  • NAID: 130005598268
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis. (2016)
  • Author(s): Chang, C.T., Wang, G.J., Kuo, C.C., Hsieh, J.Y., Lee, A.S., Chang, C.M., Wang, C.C., Shen, M.Y., Huang, C.C., Sawamura, T., Yang, C.Y., Stancel, N. and Chen, C.H.
  • Journal Title: Medicine (Baltimore) Volume: 95 Issue: 2 Pages: e2265-e2265
  • DOI: 10.1097/md.0000000000002265
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis (2016)
  • Author(s): K Hashimoto, S Mori, Y Oda, A Nakano, T Sawamura & M Akagi
  • Journal Title: Scand J Rheumatol Volume: 2 Issue: 5 Pages: 1-11
  • DOI: 10.3109/03009742.2015.1135979
  • Peer Reviewed
• [Journal Article] Serum level of Lox-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community dwelling men, especially those with hypercholesterolemia. (2016)
  • Author(s): Okamura T, Miura K, Sawamura T, Kadota A, Hisamatsu T, Fujiyoshi A, Miyamatsu N, Takashima N, Miyagawa N, Kadowaki T, Ohkubo T, Murakami Y, Nakamura Y, Ueshima H.
  • Journal Title: J Clin Lipidol. Volume: 10 Issue: 1 Pages: 172-80
  • DOI: 10.1016/j.jacl.2015.10.010
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. (2016)
  • Author(s): Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.
  • Journal Title: Blood Volume: 127 Issue: 10 Pages: 1336-1345
  • DOI: 10.1182/blood-2015-05-646117
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction. (2015)
  • Author(s): Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H
  • Journal Title: J Mol Cell Cardiol Volume: 84 Pages: 36-44
  • DOI: 10.1016/j.yjmcc.2015.03.016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cross-talk between LOX-1 and PCSK9 in vascular tissues. (2015)
  • Author(s): Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R.J., Varughese, K.I., Sawamura, T. and Mehta, J.L.
  • Journal Title: Cardiovasc Res Volume: 107 Issue: 4 Pages: 556-567
  • DOI: 10.1093/cvr/cvv178
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells. (2015)
  • Author(s): Lin, F.Y., Tsao, N.W., Shih, C.M., Lin, Y.W., Yeh, J.S., Chen, J.W., Nakagami, H., Morishita, R., Sawamura, T. and Huang, C.Y.
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: e0123971-e0123971
  • DOI: 10.1371/journal.pone.0123971
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study (2015)
  • Author(s): Sugiyama D, Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Kawamura K, Kuwabara K, Nishimura K, Kadota A, Nishida Y, Hirata T, Imano H, Miyamatsu N, Miyamoto Y, Sawamura T, Okamura T.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 5 Pages: 499-508
  • DOI: 10.5551/jat.26450
  • NAID: 130004704373
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. (2015)
  • Author(s): Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T and Rakugi H.
  • Journal Title: The FASEB Journal Volume: Apr 15 Issue: 8 Pages: 3342-3356
  • DOI: 10.1096/fj.15-271627
  • Peer Reviewed / Open Access
• [Journal Article] Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia. (2015)
  • Author(s): Morton, J. S. Quon, A. Cheung, P. Y. Sawamura, T. Davidge, S. T.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 308 Issue: 3 Pages: R163-R172
  • DOI: 10.1152/ajpregu.00222.2014
  • Peer Reviewed / Open Access
• [Journal Article] LOX-1 in atherosclerotic disease. (2015)
  • Author(s): Sawamura, T. Wakabayashi, I. Okamura, T.
  • Journal Title: Clin Chim Acta Volume: 440 Pages: 157-163
  • DOI: 10.1016/j.cca.2014.11.016
  • Peer Reviewed / Open Access
• [Journal Article] Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor. (2015)
  • Author(s): Tomita T, Ieguchi K, Sawamura T, Maru Y
  • Journal Title: PLoS One Volume: 10(3) Issue: 3 Pages: e0118835-e0118835
  • DOI: 10.1371/journal.pone.0118835
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis. (2014)
  • Author(s): Khaidakov, M., Mercanti, F., Wang, X., Ding, Z., Dai, Y., Romeo, F., Sawamura, T. and Mehta, J.L.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 306 Issue: 12 Pages: H1700-H1707
  • DOI: 10.1152/ajpheart.00043.2014
  • Peer Reviewed / Open Access
• [Journal Article] Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome (2014)
  • Author(s): Misaka T, Suzuki S, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Saitoh S, Sawamura T, Ishibashi T, Takeishi Y
  • Journal Title: BioMed Research International Volume: 2014 Pages: 649185-649185
  • DOI: 10.1155/2014/649185
  • Peer Reviewed / Open Access
• [Journal Article] LOX-1 plays an important role in ischemia-induced angiogenesis of limbs. (2014)
  • Author(s): Shiraki, T., Aoyama, T., Yokoyama, C., Hayakawa, Y., Tanaka, T., Nishigaki, K., Sawamura, T. and Minatoguchi, S.
  • Journal Title: PLoS One Volume: 9 Issue: 12 Pages: e114542-e114542
  • DOI: 10.1371/journal.pone.0114542
  • Peer Reviewed / Open Access
• [Journal Article] Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in CD14-positive mononuclear cells in hypercholesterolemic patients. (2014)
  • Author(s): Uzui, H., Hayashi, H., Nakae, I., Matsumoto, T., Uenishi, H., Hayasaki, H., Asaji, T., Matsui, S., Miwa, K., Lee, J.D., Tada, H., Sawamura, T. and Fujita, M.
  • Journal Title: Int J Cardiol Volume: 176 Issue: 3 Pages: 1230-1232
  • DOI: 10.1016/j.ijcard.2014.07.213
  • Peer Reviewed / Open Access
• [Journal Article] Small Dense Low-Density Lipoproteins Cholesterol can Predict Incident Cardiovascular Disease in an Urban Japanese Cohort: The Suita Study (2013)
  • Author(s): Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 20 Issue: 2 Pages: 195-203
  • DOI: 10.5551/jat.14936
  • NAID: 130004845433
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. (2013)
  • Author(s): 176. Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.
  • Journal Title: Blood Volume: 122 Issue: 22 Pages: 3632-3641
  • DOI: 10.1182/blood-2013-05-504639
• [Journal Article] Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor. (2013)
  • Author(s): 177. Chu, C.S., Wang, Y.C., Lu, L.S., Walton, B., Yilmaz, H.R., Huang, R.Y., Sawamura, T., Dixon, R.A., Lai, W.T., Chen, C.H. and Lu, J.
  • Journal Title: PLoS One Volume: 8 Issue: 8 Pages: e70533-e70533
  • DOI: 10.1371/journal.pone.0070533
• [Journal Article] Davidge, S.T. and Kenny, L.C. : Lectin-like oxidized low-density lipoprotein l(LOX-l) receptor inhibition protects against pre-elamspsia plasma mediated vascular dysfunction. (2013)
  • Author(s): English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T.
  • Journal Title: Am J Hypertens Volume: 26 Issue: 2 Pages: 279-286
  • DOI: 10.1093/ajh/hps035
  • Peer Reviewed
• [Journal Article] LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. (2013)
  • Author(s): Okamura T, Sekikawa A, Sawamura T, Kadowaki T, Barinas-Mitchell E, Mackey RH, Kadota A, Evans RW, Edmundowicz D, Higashiyama A, Nakamura Y, Abbott RD, Miura K, Fujiyoshi A, Fujita Y, Murakami Y, Miyamatsu N, Kakino A, Maegawa H, Murata K, Horie M, Mitsunami K, Kashiwagi A, Kuller LH, Ueshima H
  • Journal Title: Atherosclerosis Volume: 229 Issue: 1 Pages: 240-245
  • DOI: 10.1016/j.atherosclerosis.2013.04.023
  • NAID: 130004782561
  • Peer Reviewed
• [Journal Article] Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Plays an Important Role in Vascular Inflammation in Current Smokers (2013)
  • Author(s): 180. Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 20 Issue: 6 Pages: 585-590
  • DOI: 10.5551/jat.16436
  • NAID: 130004845439
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Oxidized Low Density Lipoprotein (LDL) Affects Hyaluronan Synthesis in Human Aortic Smooth Muscle Cells. (2013)
  • Author(s): 181. Viola, M., Bartolini, B., Vigetti, D., Karousou, E., Moretto, P., Deleonibus, S., Sawamura, T., Wight, T.N., Hascall, V.C., De Luca, G. and Passi, A.
  • Journal Title: The Journal of biological chemistry Volume: 288 Issue: 41 Pages: 29595-29603
  • DOI: 10.1074/jbc.m113.508341
• [Presentation] 脳出血とアテローム血栓性脳梗塞における可溶性Lectin-like oxidized LDL receptor-1高値：症例・対照研究 (2015)
  • Author(s): 横田千晶、沢村達也、渡邊至、小久保喜弘、藤田佳子、垣野明美、中井陸運、豊田一則、宮本恵宏、峰松一夫
  • Organizer: 第27回日本脳循環代謝学会総会
  • Place of Presentation: 富山県富山市、富山国際会議場
  • Year and Date: 2015-10-30
• [Presentation] 多様な分子との相互作用から明らかになってきたLOX-1の新しい病態生理学的意義 (2015)
  • Author(s): 沢村達也
  • Organizer: 第10回神戸生活習慣病研究会
  • Place of Presentation: 兵庫県神戸市、ラッセルホール
  • Year and Date: 2015-07-04
• [Presentation] 多様な分子と相互作用する受容体LOX-1の病態生理学的意義 (2015)
  • Author(s): 沢村達也
  • Organizer: 第1回 J-ISCP(国際心血管薬物療法学会日本部会)学術集会
  • Place of Presentation: 京都府京都市、ハイアットリージェンシー京都
  • Year and Date: 2015-06-20
• [Presentation] AT1はLOX-1を介した酸化LDLによるシグナル伝達を促進する (2015)
  • Author(s): 垣野明美、山本浩一、藤田佳子、楽木宏美、沢村達也
  • Organizer: 第1回J-ISCP学術集会
  • Place of Presentation: 京都府京都市、ハイアットリージェンシー京都
  • Year and Date: 2015-06-20
• [Presentation] PAF receptor interacts with LOX-1 and promotes oxidized LDL-induced cellular responses (2015)
  • Author(s): Kakino, A., Fujita, Y., Yamamoto, K., Rakugi, H., Sawamura, T
  • Organizer: 17th International Congress on Atherosclerosis 2015
  • Place of Presentation: Amsterdam (Holland)
  • Year and Date: 2015-05-23
  • Int'l Joint Research
• [Presentation] LOX-1: the receptor for modified LDL and beyond. (2015)
  • Author(s): Tatsuya Sawamura
  • Organizer: International Symposium:New Era of Lipid and Glycomedicine Research
  • Place of Presentation: 高雄、台湾
  • Year and Date: 2015-03-23
  • Invited
• [Presentation] AT1 promotes oxLDL-induced cell responses through interact with LOX-1. (2015)
  • Author(s): Akemi Kakino, Koichi Yamamoto, Lei Li, Yoshiko Fujita, Hiromi Rakugi, Tatsuya Sawamura
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Interaction between AT1 and LOX-1 promote oxLDL-induced cell responses. (2015)
  • Author(s): Akemi Kakino, Koichi Yamamoto, Lei Li, Yoshiko Fujita, Hiromi Rakugi, Tatsuya Sawamura
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] LOX-1 遺伝子欠損SHRSPの作製とその形質の予備的解析 (2014)
  • Author(s): 垣野明美、李 蕾、池末昌弘、中野厚史、藤田佳子、岡澤 慎、真下知士、沢村達也
  • Organizer: 第50回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 和歌山県立医科大学 生涯研修センター、和歌山
  • Year and Date: 2014-12-06
• [Presentation] Overexpression of Del-1, An oxidized LDL blocking protein, suppressed atherogenesis in mice without lowering oxidized LDL concentration, but with reducing LOX-1 ligand containing apoB activity (LAB). (2014)
  • Author(s): Akemi. Kakino, Atsushi Nakano, Yoshiko Fujita, Tatsuya Sawamura.
  • Organizer: American Association for Clinical Chemistry Annual Meeting and Clinical Lab Expo
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2014-07-30
• [Presentation] AT1 directly interacting with LOX-1 mediates signal transduction induced by oxidized LDL. (2014)
  • Author(s): A. Kakino, K.Yamamoto, A.Nakano, L.Li, Y. Fujita, H.Rakugi, T.Sawamura
  • Organizer: The 82nd Congress of the European Atherosclerosis Society (EAS 2014)
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2014-06-01
• [Presentation] 活動電位依存的な小脳顆粒細胞の成熟メカニズム (2014)
  • Author(s): 岡澤慎
  • Organizer: 第10回宮崎サイエンスキャンプ
  • Place of Presentation: 宮崎
• [Presentation] Regulation Of Cellular Lipid Metabolism In Atherogenesis (2013)
  • Author(s): Akemi Kakino, Atsushi Nakano, Yoshiko Fujita, Tatsuya Sawamura
  • Organizer: The 81st Congress of the European Atherosclerosis Society (EAS 2013)
  • Place of Presentation: フランス・リヨン
• [Presentation] LOX-1 ligands containing apolipoprotein B and catroid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men (2013)
  • Author(s): Tatsuya Sawamura
  • Organizer: AACC annual meeting&clinical lab expo 2013
  • Place of Presentation: アメリカ・ヒューストン
• [Presentation] AT1はLOX-1を介した酸化LDLによるシグナル伝達と血管壁脂質沈着を促進する (2013)
  • Author(s): 垣野明美、山本浩一、中野厚史、李蕾、藤田佳子、楽木宏実、沢村達也
  • Organizer: 第49回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 東京
• [Presentation] An endogenous blocker of oxidized LDL (2013)
  • Author(s): Akemi Kakino, Atsushi Nakano, Yoshiko Fujita, Tatsuya Sawamura
  • Organizer: 13th International Conference on Endothelin (ET-13)
  • Place of Presentation: 東京
• [Presentation] 内因性蛋白質による新しい酸化LDL作用阻害機構 Inhibition of oxidized LDL action by an endogenous protein (2013)
  • Author(s): 垣野明美、中野厚史、藤田佳子、沢村達也
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] Identification of Endogenous Anti-Atherogenic Protein Which Blocks the Interaction between Oxidized LDL and Its Receptors (2013)
  • Author(s): Akemi Kakino, Atsushi Nakano, Yoshiko Fujita, Tatsuya Sawamura
  • Organizer: AHA Scientific Sessions 2013
  • Place of Presentation: アメリカ・ダラス
• [Presentation] Del-1は酸化LDL－受容体相互作用を阻害し、血管壁脂質沈着を抑制する Del-1 as an endogenous blocker of oxidized LDL which suppresses arterial lipid accumulation (2013)
  • Author(s): 垣野明美、中野厚史、藤田佳子、沢村達也
  • Organizer: 第17回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 異物受容体としてのLOX-1から見た新展開 (2013)
  • Author(s): 沢村達也
  • Organizer: 第17回日本心血管内分泌代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] LOX-1は血管内皮障害から動脈硬化性疾患発症を担う
  • Author(s): 沢村達也
  • Organizer: 第13回日本NO学会学術集会
  • Place of Presentation: 沖縄
  • Invited
• [Presentation] 酸化LDL受容体LOX-1を利用した変性LDL測定方法と動脈硬化性疾患の評価
  • Author(s): 沢村達也
  • Organizer: 第45回日本臨床検査自動化学会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 酸化LDL阻害分子Del-1の過剰発現は、マウス血管壁脂質沈着を抑制する
  • Author(s): 垣野明美、中野厚史、藤田佳子、沢村達也
  • Organizer: 第23回日本循環薬理学会
  • Place of Presentation: 福岡
• [Patent(Industrial Property Rights)] 酸化ＬＤＬ阻害剤 (2015)
  • Inventor(s): 沢村達也、垣野明美
  • Industrial Property Rights Holder: 国立研究開発法人国立循環器病研究センター、国立大学法人信州大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-08-15
  • Acquisition Date: 2016-02-19
• [Patent(Industrial Property Rights)] LOX-1 阻害活性を高めた後発酵茶精製組成物 (2014)
  • Inventor(s): 沢村達也、新家康弘、土井聡、來住明宜、松川泰治、
  • Industrial Property Rights Holder: 独立行政法人 国立循環器病研究センター、ユーハ味覚糖株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-001888
  • Filing Date: 2014-01-08
• [Patent(Industrial Property Rights)] 抗血液凝固剤 (2013)
  • Inventor(s): 沢村達也、藤田佳子、垣野明美
  • Industrial Property Rights Holder: 独立行政法人 国立循環器病研究センター
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-273308
  • Filing Date: 2013-12-27