Analysis of novel oxidative stress response mechanism via ribosome
| Project/Area Number |
25293064
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
Itoh Ken 弘前大学, 医学研究科, 教授 (10323289)
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| Co-Investigator(Kenkyū-buntansha) |
松宮 朋穂 弘前大学, 医学研究科, 助教 (30344592)
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| Co-Investigator(Renkei-kenkyūsha) |
MIMURA Junsei 弘前大学, 大学院医学研究科, 講師 (60344884)
MARUYAMA Atsushi 東北医科薬科大学, 薬学部, 講師 (10431438)
HIMENO Hyouta 弘前大学, 農学生命科学部, 教授 (80208785)
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | リボソーム / アミノ酸飢餓 / GCN1L1 / Nrf2 / ATF4 / ストレス応答 / GCN1 / 酸化ストレス / ミトコンドリア / HO-1 |
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| Outline of Final Research Achievements |
In order to clarify the roles of GCN1L1, we generated GCN1L1 mice lacking RWDBD (GCN1L1 delta RWDBD) that is required for GCN1L1 binding to RWD possessing proteins such as GCN2 and DFRP2. The embryos of GCN1L1 delta RWDBD mice shows growth retardation starting from at least 12.5 dpc and died soon after birth. The embryonic fibroblasts obtained from GCN1L1 delta RWDBD mice shows slower prolifferation compared to those of wild-type mice associting with G2/M cell cycle arrest and decreased levels of DRG2 that heterodimerizes with DFRP2. These results suggest that GCN1L1 controls cell proliferation via the regulation of DRG2/DFRP2.
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Report
(6 results)
Research Products
(41 results)
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[Journal Article] The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects in combination with quinone-containing compounds and anti-microtubule drugs2016
Author(s)
2.Liu PY, Sokolowski N, Guo ST, Siddiqi F, Atmadibrata B, Telfer TJ, Sun Y, Zhang L, Yu D, Mccarroll J, Liu B, Yang RH, Guo XY, Tee AE, Itoh K, Wang J, Kavallaris M, Haber M, Norris MD, Cheung BB, Byrne JA, Ziegler DS, Marshall GM, Dinger ME, Codd R, Zhang XD, Liu T
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Journal Title
Oncotarget
Volume: 7
Issue: 48
Pages: 79217-79232
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Nrf2- and ATF4-dependent up-regulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.2014
Author(s)
Peng Ye, P., Mimura J., Okada, T., Sato, H., Liu, T., Maruyama, A., Ohyama, C., and Itoh, K.
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Journal Title
Mol. Cell. Biol.
Volume: 34
Issue: 18
Pages: 3421-3434
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain.2014
Author(s)
Tanji K, Miki Y, Ozaki T, Maruyama A, Yoshida H, Mimura J, Matsumiya T, Mori F, Imaizumi T, Itoh K, Kakita A, Takahashi H, Wakabayashi K.
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Journal Title
Acta Neuropathologica Communications
Volume: 未定
Related Report
Peer Reviewed
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