| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
The acquired immune response is mediated by lymphocytes, which express highly diverse receptors. After lymphocytes specifically recognize the antigen through their specific receptors, immune reactions started. Thus, immune responses of lymphocytes are specific for distinct antigens. This system provides big benefit when invaded by microbes or virus. On the other hand, immune reaction against self-antigens will be harmful. Such kind of immune reactions are called autoimmunity, which result in autoimmune disease. To prevent autoimmune disease, tolerance to self-antigens are established. During the normal course of immune reactions, excessive immune reactions will provide adverse effect. To minimize such kind of adverse effect, existence of antigen-specific immune suppression was proposed, but not clearly demonstrated yet. In this project, we examined what kinds of cells work as antigen-specific immune suppression cells, and how they exert their function.
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