Molecular mechanism of the regulation of antigen-specific immune reaction
Project/Area Number |
25293069
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
Shimizu Akira 京都大学, 医学研究科, 教授 (00162694)
|
Co-Investigator(Kenkyū-buntansha) |
菅井 学 京都大学, 医学(系)研究科(研究院), 講師 (90303891)
|
Project Period (FY) |
2013-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
|
Keywords | 自己免疫疾患 / 免疫抑制 / 獲得免疫 / 免疫寛容 / 自己免疫 / 免疫制御 / 腫瘍免疫 / 腫瘍免疫疾患 |
Outline of Final Research Achievements |
The acquired immune response is mediated by lymphocytes, which express highly diverse receptors. After lymphocytes specifically recognize the antigen through their specific receptors, immune reactions started. Thus, immune responses of lymphocytes are specific for distinct antigens. This system provides big benefit when invaded by microbes or virus. On the other hand, immune reaction against self-antigens will be harmful. Such kind of immune reactions are called autoimmunity, which result in autoimmune disease. To prevent autoimmune disease, tolerance to self-antigens are established. During the normal course of immune reactions, excessive immune reactions will provide adverse effect. To minimize such kind of adverse effect, existence of antigen-specific immune suppression was proposed, but not clearly demonstrated yet. In this project, we examined what kinds of cells work as antigen-specific immune suppression cells, and how they exert their function.
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Report
(6 results)
Research Products
(13 results)
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[Journal Article] Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development.2016
Author(s)
Togo Y., Takahashi K., Saito K., Kiso H., Tsukamoto H., Huang B., Yanagita M., Sugai M., Harada H., Komori T., Shimizu A., MacDougall M., Bessho K.
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Journal Title
PLoS One
Volume: 11
Issue: 8
Pages: e0161067-e0161067
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney2016
Author(s)
Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.
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Journal Title
JCI. Insight.
Volume: 1
Issue: 11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Mitochondrial function provides instructive signals for activation-induced B cell fates2015
Author(s)
Kyoung-Jin Jang, Hiroto Mano, Koji Aoki, Tatsunari Hayashi, Yukiko Nambu, Eri Hara, Katsu Takahashi, Katsuhiko Itoh, Shigeru Taketani, Kazuhiko Igarashi, Akira Shimizu and Manabu Sugai
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Journal Title
Nature Commun
Volume: 6
Issue: 1
Pages: 6750-6750
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Safety and Anti-tumor Activity of Anti–PD-1 Antibody (Nivolumab: ONO-4538/BMS-936558) in Patients with Platinum-resistant Ovarian Cancer.2015
Author(s)
Hamanishi, J., M. Mandai, T. Ikeda, M. Minami, A. Kawaguchi, T. Murayama, M. Kanai, Y. Mori, S. Matsumoto, S. Chikuma, N. Matsumura, K. Abiko, T. Baba, K. Yamaguchi, A. Ueda, Y. Hosoe, S. Morita, M. Yokode, A. Shimizu, T. Honjo, I. Konishi.
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Journal Title
J Clin Oncol
Volume: 33
Issue: 34
Pages: 4015-22
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations2014
Author(s)
Honoka Kiso, Katsu Takahashi , Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Yasuhiko Tabata, Aris N. Economides, Harold C. Slavkin, Kazuhisa Bessho
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Journal Title
PlosOne
Volume: 9
Issue: 5
Pages: 96938-96944
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma2014
Author(s)
Shinya Ohashi, Osamu Kikuchi, Mihoko Tsurumaki, Yukie Nakai, Daisuke Kuriyama, Hiroi Kasai, Takahiro Horimatsu, Shin’ichi Miyamoto, Akira Shimizu, Tsutomu Chiba, Manabu Muto
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Journal Title
PLOS ONE
Volume: 9
Issue: 8
Pages: e103126-e103126
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment.2014
Author(s)
Nakagawa T., Kumakawa K., Usami S., Hato N., Tabuchi K., Takahashi M., Fujiwara K., Sasaki A., Komune S., Sakamoto T., Hiraumi H., Yamamoto N., Tanaka S., Tada H., Yamamoto M., Yonezawa A., Ito-Ihara T., Ikeda T., Shimizu A., Tabata Y., and Ito J.
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Journal Title
BMC Med
Volume: 12
Issue: 1
Pages: 219-219
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.2014
Author(s)
Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H.
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Journal Title
J. Biol. Chem.
Volume: 289
Issue: 3
Pages: 1564-1579
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of the indocyanine green fluorescence and blue dye methods in detection of sentinel lymph nodes in early-stage breast cancer.2013
Author(s)
Sugie, T., Sawada, T., Tagaya, N., Kinoshita, T., Yamagami, K., Suwa, H., Ikeda, T., Yoshimura, K., Niimi, M., Shimizu, A. and Toi, M.
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Journal Title
Annal. Surg. Oncol.
Volume: 20
Issue: 7
Pages: 2213-2218
DOI
Related Report
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[Journal Article] Evasion from accelerated blood clearance of nanocarrier named as "Lactosome" induced by excessive administration of Lactosome.2013
Author(s)
Hara, E., Makino, A., Kurihara, K., Sugai, M., Shimizu, A., Hara, I., Ozeki, E. and Kimura, S.
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Journal Title
Biochem. Biophys. Acta-General Sub.
Volume: 1830
Issue: 8
Pages: 4046-4052
DOI
Related Report
Peer Reviewed