Investigation of molecular mechanisms underlying synapse formation between photoreceptor, bipolar and horizontal cells
| Project/Area Number |
25293070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Omori Yoshihiro 大阪大学, たんぱく質研究所, 准教授 (90469651)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 網膜 / 視細胞 / 双極細胞 / 水平細胞 / リボンシナプス / シナプス / 遺伝子欠損マウス / 膜貫通蛋白質 / electroretinogram (ERG) |
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| Outline of Final Research Achievements |
In the vertebrate retina, visual information is transmitted from photoreceptor cells to ganglion cells via bipolar cells. The photoreceptor axon terminal forms a specialized synaptic structure, the ribbon synapse, which specifically connects photoreceptor axonal terminals with bipolar and horizontal cell dendritic terminals in the outer plexiform layer. Although various presynaptic proteins which are required for synaptic ribbon structure, such as Ctbp2, piccolo and bassoon, have been identified, the mechanism of ribbon synapse apposition specific to bipolar and horizontal terminals remains mostly unknown. We investigated molecular mechanisms underling the proper formation of photoreceptor ribbon synapses.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.2014
Author(s)
Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T.
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Journal Title
Human molecular genetics
Volume: -
Issue: 11
Pages: 2953-2967
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model2013
Author(s)
Daisuke Yamazaki, Yosuke Funato, Jiro Miura, Sunao Sato, Satoru Toyosawa, Kazuharu Furutani, Yoshihisa Kurachi, Yoshihiro Omori, Takahisa Furukawa, Tetsuya Tsuda, Susumu Kuwabata, Shin Mizukami, Kazuya Kikuchi, Hiroaki Miki
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Journal Title
PLoS Genetics
Volume: 9(12)
Issue: 12
Pages: e1003983-e1003983
DOI
Related Report
Peer Reviewed
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