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Investigation of molecular mechanisms underlying synapse formation between photoreceptor, bipolar and horizontal cells

Research Project

Project/Area Number 25293070
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionOsaka University

Principal Investigator

Omori Yoshihiro  大阪大学, たんぱく質研究所, 准教授 (90469651)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords網膜 / 視細胞 / 双極細胞 / 水平細胞 / リボンシナプス / シナプス / 遺伝子欠損マウス / 膜貫通蛋白質 / electroretinogram (ERG)
Outline of Final Research Achievements

In the vertebrate retina, visual information is transmitted from photoreceptor cells to ganglion cells via bipolar cells. The photoreceptor axon terminal forms a specialized synaptic structure, the ribbon synapse, which specifically connects photoreceptor axonal terminals with bipolar and horizontal cell dendritic terminals in the outer plexiform layer. Although various presynaptic proteins which are required for synaptic ribbon structure, such as Ctbp2, piccolo and bassoon, have been identified, the mechanism of ribbon synapse apposition specific to bipolar and horizontal terminals remains mostly unknown. We investigated molecular mechanisms underling the proper formation of photoreceptor ribbon synapses.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (20 results)

All 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Invited: 4 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice2015

    • Author(s)
      Mizuhashi K, Chaya T, Kanamoto T, Omori Y, Furukawa T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0133704-e0133704

    • DOI

      10.1371/journal.pone.0133704

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control2015

    • Author(s)
      Omori Y, Chaya T, Yoshida S, Irie S, Tsujii T, Furukawa T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0128422-e0128422

    • DOI

      10.1371/journal.pone.0128422

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.2015

    • Author(s)
      Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T.
    • Journal Title

      Genes to Cells

      Volume: 印刷中 Issue: 5 Pages: 408-26

    • DOI

      10.1111/gtc.12233

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport2014

    • Author(s)
      Chaya T, Omori Y, Kuwahara R, Furukawa T
    • Journal Title

      EMBO J

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.2014

    • Author(s)
      Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T.
    • Journal Title

      Human molecular genetics

      Volume: - Issue: 11 Pages: 2953-2967

    • DOI

      10.1093/hmg/ddu007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 網膜の発生研究と再生医療への応用2014

    • Author(s)
      渡邉哲史、大森義裕、古川貴久
    • Journal Title

      生体の科学

      Volume: 未定

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 古くて新しいオルガネラ,「繊毛」研究の広がり2014

    • Author(s)
      大森義裕
    • Journal Title

      生物工学会誌

      Volume: 92 Pages: 117-117

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model2013

    • Author(s)
      Daisuke Yamazaki, Yosuke Funato, Jiro Miura, Sunao Sato, Satoru Toyosawa, Kazuharu Furutani, Yoshihisa Kurachi, Yoshihiro Omori, Takahisa Furukawa, Tetsuya Tsuda, Susumu Kuwabata, Shin Mizukami, Kazuya Kikuchi, Hiroaki Miki
    • Journal Title

      PLoS Genetics

      Volume: 9(12) Issue: 12 Pages: e1003983-e1003983

    • DOI

      10.1371/journal.pgen.1003983

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 次世代の担い手たちが作る神経科学の新しい潮流2013

    • Author(s)
      大森義裕
    • Journal Title

      神経科学ニュース

      Volume: 3 Pages: 8-9

    • Related Report
      2013 Annual Research Report
  • [Presentation] Mef2dによる転写制御はマウス網膜における視細胞と双極細胞の成熟に必須である2015

    • Author(s)
      吉田怜代, 大森義裕, 北村民樹, 桒原隆亮, 茶屋太郎, 入江彰, 古川貴久
    • Organizer
      日本神経科学大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Otx2欠損マウス網膜の遺伝子発現プロファイル解析と錐体双極細胞に発現する膜貫通蛋白質Tmem215の同定2014

    • Author(s)
      吉田 怜代, 入江 彰一, 岡本 志央, 北村 民樹, 笠 知晴, 大森 義裕, 古川 貴久
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 繊毛キナーゼによる繊毛内輸送システムの制御と繊毛関連疾患の発症メカニズム

    • Author(s)
      大森義裕、茶屋太郎、古川貴久
    • Organizer
      日本解剖学会学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ciliary kinase ICK is essential for ciliogenesis in neural progenitor cells and Hedgehog signaling

    • Author(s)
      大森義裕、茶屋太郎、古川貴久
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional role of ciliary kinases in cilia development and human disease

    • Author(s)
      Yoshihiro Omori, Taro Chaya, Takahisa Furukawa
    • Organizer
      The 8th International Symposium of the Institute Network
    • Place of Presentation
      Shiran Kaikan, Kyoto
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ciliary Kinase ICK is required for Ciliogenesis in Neural Progenitor Cells and Hedgehog Signaling

    • Author(s)
      Yoshihiro Omori, Taro Chaya, Takahisa Furukawa
    • Organizer
      The 25th CDB Meeting, Cilia and Centrosomes
    • Place of Presentation
      Riken CDB, Kobe
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 細胞工学別冊 最新バイオ論文解説総集編「マウス胚発生における細胞系譜に特異的な一次繊毛の形成」2015

    • Author(s)
      大森義裕
    • Publisher
      秀潤社
    • Related Report
      2015 Annual Research Report
  • [Book] Vertebrate Photoreceptors: Functional Molecular Bases2014

    • Author(s)
      Omori Y, Furukawa T.
    • Publisher
      Springer Japan
    • Related Report
      2013 Annual Research Report
  • [Remarks] さきがけ研究者 大森義裕の研究内容

    • URL

      http://yoshihiroomori.web.fc2.com/

    • Related Report
      2015 Annual Research Report
  • [Remarks] http://yoshihiroomori.web.fc2.com/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 大森義裕 研究内容

    • URL

      http://yoshihiroomori.web.fc2.com/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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