| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
Vesicle traffic plays important roles in various cellular events, such as exocytosis of hormone or digestive enzyme, and endocytosis of growth factor. SNARE proteins are essential for vesicle traffic. The amount of v-SNARE proteins on the vesicle and the amount of t-SNARE proteins on the target membrane regulate the speed of vesicle fusion. We have identified membrane insertion complex for SNARE proteins, CAML complex. To elucidate regulatory mechanism of membrane insertion of SNARE proteins, we identified p47 as a CAML-interacting protein. We also revealed subcellular localization mechanism of a SNARE protein lacking SNARE motif, Sec22c.
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